Seema zargar

Prof. Seema Zargar
                 
Postal Address:                                                         Phone:            8051692
E-mail:            szargar@ksu.edu.sa
Department of Biochemistry
College of science, King Saud university
Prince Turkey Road
Riyadh; Saudi Arabia-11495
PROFESSIONAL QUALIFICATIONS: Ph.D Biotechnology. 
RESEARCH TOPIC  of PhD: Molecular mechanism of pathogenesis of dengue virus and its interaction with host cell proteins.
SUMMARY OF THESIS
 Purification of recombinant envelope protein of Dengue virus  (infective domain) was done by Ni-NTA affinity column and it was labeled and interacted with blotted  two dimensional gels of total proteins of mammalian cells. This interaction could show us the proteins that might be responsible for DEN-virus entry or its propagation in mammalian cells. The principal techniques used in the study were Isolation of total proteins, one dimensional gel electrophoresis, two dimensional gel electrophoresis, far Western blotting, Ni-NTA protein purification of expressed proteins, electron microscopy and MALDI-TOF analysis, etc 
WORK EXPERIENCE:
Academic editor Biomed Research International and guest editor of molecules
2021- till date: Professor of Biochemistry at King Saud University Riyadh
2016-2020: Associate Professor at King Saud University. Riyadh.
 2011-2016: Assistant Professor at King Saud University. Riyadh.
 2009-2011: Associate Scientist at King Faisal Hospital and Research Centre, Riyadh.
 2004-2009: PhD Biotechnology, Jamia Hamdard. 
EXPERTISE DEVELOPED DURING Post doctorate
 FACS analysis of CD3, CD4 and CD8, CD25, CD44 and Ki67 antibodies.
 MACS separation of different cell types (Magnetic cell sorting)
 Adipose tissue separation and culturing from lipoaspirate of abdominal fat or gluteal fat tissue
 Elisa for IL-6, adiponectin, Insulin, leptin,TNF-a and other adipokines.
 Isolation of thymocytes and splenocytes from mice and their culture.
 Extraction of DNA from mouse tail and their genotypic.
 Extraction of protein and Western blotting of cell lysates.
 Culturing of different types of primary and secondary cultures including established cell lines.
 Gene expression by Reverse transcription PCR.
 Cloning, cDNA library preparation  and yeast two hybrid selection, Real time PCR, tunnel assay and double immunofluorescence.
 Supervising Trainees and students from other institutes like King Saud University, Alfaisal University, College of Pharmacy and Dentistry, etc.
 TEACHING EXPERIENCE
Topics Taught include: Genetic manipulation and gene therapy, Advances in genomics and Bioinformatics, Recent aspects in molecular genetics, Recent advances in metabolism, Advanced bioanalytical techniques, advances in biochemical research, Biomembranes, Biochemistry of specialized tissues, Biotechnology and genetic engineering, Gene, Genetics, molecular carcinogenesis, Antibiotics, Immunology, Gene expression, bioinformatics, molecular Biology, selected Topics in Biochemistry, inborn errors of metabolism, Biochemistry of Blood.

Currently supervising

Targeting the effect of metformin and dioxin on cancer cells through DNA repair pathways and telomerase extension 

Mechanisms underlying the therapeutic effect of atorvastatin on LPS-induced breast cancer cell by regulation NFκB pathway

 SUPERVISED  FOLLOWING THESES 
Molecular basis of regulation of cancer progression by Poziotinib and its combination with olmutinib

In vivo study of effects of intervention of olmutinib alone and with wheat germ oil on

cell signaling pathways in thioacetamide induced mice

Study the Role of AUF1 Inhibition in Chemo Sensitization of Osteosarcoma Cells

Analysis of the potential molecular effects of Tartrazine and high dose exposure of Aspirin on cell cycle in rat brain
2.Cross-omics analysis of neratinib induced effects on different tissues of mice
Effect of expression of STK11 and its promoter activity in human breast cancer cell lines. (PI)
Molecular Basis of Hereditary Spastic Paraplegia in Saudi Population (PI).
Role of Angplt8 Betatrophin gene polymorphism in Metabolic syndrome manifestations among Saudi subjects (PI).
The effect of Gum Arabic on cholesterol synthesis and serum lipids of atherogenic rats (PI).
Genetic screening of Saudi neonates for the neonatal diabetes associated mutations in ABCC8 gene (PI)
2.  Polymorphic pattern of certain genes in ovarian cancer in Saudi patients. (Co-PI)
3. Innate immunity and ovarian cancer: Role of the inflammatory cytokines (IL-1b  and TNF-a) and their receptors (IL-1 receptor and TNF receptor). (Co-PI)  
4. Anti-microbial activity of zingier officinal and curcum longa extracts against some selected micro-organisms’. (PI) 
5. Efficacy of medicinal plant extracts in growth of fungi and subsequent production of citrinin(PI) (selected in Scientific excellence for King Saud university students)
6. Assessment various impurities of water from several well water supplies from Riyadh region of Saudi Arabia (PI) .
7. Efficacy of date extract on inhibition of Citrinin production by Penicillium notatum and Aspergillus flavus (PI).
8. Cloning and sequencing of camel SOD gene (co-PI)  
Other Activities
Member, Postgraduate Committee                                                     2014-2020
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.   

Member, curriculum Committee                                                     2016-2020
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.   
 
Member, Accreditation Committee                                                     2016-2017
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.   
  
Member, Laboratory Committee                                                          2011-2013
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.   
                                                                                                    
Member, Examination Committee                                                        2011-2014
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.    

Member, Safety Committee                                                                  2011-2013
Department of Biochemistry, College of Science,        
Sciences & Medical Studies Department for Women Students,
King Saud University, Riyadh, Saudi Arabia.   

 ACHIEVEMENTS: 
Scored second position in M. Sc Biochemistry 
Qualified JRF and Eligibility for Lectureship (NET) held on 22nd June 2003 conducted by Council of Scientific and Industrial Research, New Delhi (All India Level Exam).  
Senior Research Fellowship from Council of Scientific and Industrial Research (All India Level Eligibility Test).
Qualified GATE 2004 with 94.5 percentile at All India Level.
LIST OF PUBLICATIONS:

1. Ullah S, Sirajuddin M, Ullah Z, Mushtaq A, Naz S, Zubair M, Haider A, Ali S, Kubicki M, Wani TA, Seema Zargar. Synthesis, Structural Elucidation and Pharmacological Applications of Cu (II) Heteroleptic Carboxylates. Pharmaceuticals. 2023 May 3;16(5):693.
2. Khan, Hizbullah, Muhammad Sirajuddin, Amin Badshah, Sajjad Ahmad, Muhammad Bilal, Syed Muhammad Salman, Ian S. Butler, Tanveer A. Wani, and Seema Zargar. "Synthesis, Physicochemical Characterization, Biological Evaluation, In Silico and Molecular Docking Studies of Pd (II) Complexes with P, S-Donor Ligands." Pharmaceuticals 16, no. 6 (2023): 806.
3. Ahmad, Saghir, Muhammad Abdul Qadir, Mahmood Ahmed, Muhammad Imran, Numan Yousaf, Tanveer A. Wani, Seema Zargar, Ijaz Ali, and Muhammad Muddassar. "New acetamide-sulfonamide-containing scaffolds: Antiurease activity screening, structure-activity relationship, kinetics mechanism, molecular docking, and md simulation studies." Molecules 28, no. 14 (2023): 5389.
4. Ejaz, Syeda Abida, Aftab Farid, Seema Zargar, Pervaiz Ali Channar, Mubashir Aziz, Tanveer A. Wani, Hafiz Muhammad Attaullah et al. "Computational and theoretical chemistry of newly synthesized and characterized 2, 2’-(5, 5’-(1, 4-phenylene) bis (1 H-tetrazole-5, 1-diyl)) bis-N-acetamides." BMC chemistry 17, no. 1 (2023): 97.
5. Khushal, Aneela, Umar Farooq, Sara Khan, Azhar Rasul, Tanveer A. Wani, Seema Zargar, Sohail Anjum Shahzad, Syed Majid Bukhari, and Nazeer Ahmad Khan. "Bioactivity-Guided Synthesis: In Silico and In Vitro Studies of β-Glucosidase Inhibitors to Cope with Hepatic Cytotoxicity." Molecules 28, no. 18 (2023): 6548.
6. Qureshi MI, Jamil QA, Usman F, Wani TA, Farooq M, Shah HS, Ahmad H, Khalil R, Sajjad M, Zargar Seema, Kausar S. Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro, In Vivo, and Molecular Docking Approaches. Gels. 2023 Sep 21;9(9):767.
7. Usman, Faisal, Mudassir Farooq, Tanveer A. Wani, Hassan Ahmad, Ibrahim Javed, Mazhar Iqbal, Fatima Akbar Sheikh, Farhan Siddique, Seema Zargar, and Saleh Sheikh. "Itraconazole Loaded Biosurfactin Micelles with Enhanced Antifungal Activity: Fabrication, Evaluation and Molecular Simulation." Antibiotics 12, no. 10 (2023): 1550.
8. Alamery, Salman, Anfal AlAjmi, Tanveer A. Wani, and Seema Zargar. "In Silico and In Vitro Exploration of Poziotinib and Olmutinib Synergy in Lung Cancer: Role of hsa-miR-7-5p in Regulating Apoptotic Pathway Marker Genes." Medicina 59, no. 11 (2023): 1923.
9. Ahmed, Mahmood, Syed Salman Shafqat, Amna Javed, Mudassar Sanaullah, Abdul Shakoor, Muhammad Imtiaz Shafiq, Syeda Kiran Shahzadi, Tanveer A. Wani, and Seema Zargar. "Exposure Assessment of Essential and Potentially Toxic Metals in Wheat-Based Sweets for Human Consumption: Multivariate Analysis and Risk Evaluation Studies." Molecules 28, no. 21 (2023): 7365.
10. Ejaz, Syeda Abida, Mubashir Aziz, Ammara Fayyaz, Tanveer A. Wani, and Seema Zargar. "Computer-aided approach for the identification of lead molecules as the inhibitors of cholinesterase’s and monoamine oxidases: novel target for the treatment of Alzheimer’s disease." Journal of the Serbian Chemical Society (2023).
11. Shahzadi, Kiran, Syed Majid Bukhari, Asma Zaidi, Tanveer A. Wani, Muhammad Saeed Jan, Seema Zargar, Umer Rashid, Umar Farooq, Aneela Khushal, and Sara Khan. "Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation." Pharmaceuticals 16, no. 11 (2023): 1552.
12. Samee, Ayesha, Faisal Usman, Tanveer A. Wani, Mudassir Farooq, Hamid Saeed Shah, Ibrahim Javed, Hassan Ahmad, Riffat Khan, Seema Zargar, and Safina Kausar. "Sulconazole-Loaded Solid Lipid Nanoparticles for Enhanced Antifungal Activity: In Vitro and In Vivo Approach." Molecules 28, no. 22 (2023): 7508.
13. Ejaz, Syeda Abida, M. Sajjad Bilal, Mubashir Aziz, Tanveer A. Wani, Seema Zargar, Ammara Fayyaz, Sidra Hassan, Aftab Ahmed, Hammad M. Al Kahtani, and Farhan Siddique. "Computational Exploration of Fluorocyclopentenyl‐purines and–pyrimidines Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor (EGFR) for the Treatment of Breast Cancer." Chemistry & Biodiversity (2023): e202301190.
14. Ahmad, Saghir, Muhammad Abdul Qadir, Mahmood Ahmed, Muhammad Imran, Muhammad Ahmad, Numan Yousaf, Tanveer A. Wani, Seema Zargar, Ijaz Ali, and Muhammad Muddassar. "Exploring the Potential of New Benzamide-Acetamide Pharmacophore Containing Sulfonamide as Urease Inhibitors: Structure–Activity Relationship, Kinetics Mechanism, and In Silico Studies." ACS Omega (2023).
15. Zargar S, Wani TA. Food Toxicity of Mycotoxin Citrinin and Molecular Mechanisms of Its Potential Toxicity Effects through the Implicated Targets Predicted by Computer-Aided Multidimensional Data Analysis. Life. 2023 Mar 26;13(4):880.
16. Zargar, S.; Altwaijry, N.; Wani, T.A.; Alkahtani, H.M. Evaluation of the Possible Pathways Involved in the Protective Effects of Quercetin, Naringenin, and Rutin at the Gene, Protein and miRNA Levels Using In-Silico Multidimensional Data Analysis. Molecules 2023, 28, 4904.
17. Shariq M, Mahmood T, Kushwaha P, Parveen S, Shamim A, Ahsan F, Wani TA, Zargar S, Wasim R, Wahajuddin M. Fabrication of Nanoformulation Containing Carvedilol and Silk Protein Sericin against Doxorubicin Induced Cardiac Damage in Rats. Pharmaceuticals. 2023 Apr 7;16(4):561.
18. Wani TA, Zargar S. Molecular Spectroscopy Evidence of 1, 3, 5-Tris (4-carboxyphenyl) benzene Binding to DNA: Anticancer Potential along with the Comparative Binding Profile of Intercalation via Modeling Studies. Cells. 2023 Apr 10;12(8):1120.
19. Zargar S, Wani TA, Rizwan Ahamad S. An insight into wheat germ oil nutrition, identification of its bioactive constituents and computer-aided multidimensional data analysis of its potential anti-inflammatory effect via molecular connections. Life. 2023 Feb 14;13(2):526.
20. Wani, TA; Bakheit, AH; Zargar, S, Altwaijry, N,  ; Bhat, MA,  Alkahtani, HM; Al-Rasheed, LS. Toxicity Study and Binding Analysis of Newly Synthesized Antifungal N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide Derivative with Bovine Serum Albumin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. March 2023
21. Rehman MU, Ali A, Ansar R, Arafah A, Imtiyaz Z, Wani TA, Zargar S, Ganie SA. In Silico molecular docking and dynamic analysis of natural compounds against major non-structural proteins of SARS-COV-2. J Biomol Struct Dyn. 2022 Nov 3:1-17. doi: 10.1080/07391102.2022.2139766. Epub ahead of print. PMID: 36326281.
22. Bilal, M.S.; Ejaz, S.A.; Zargar, S.; Akhtar, N.;Wani, T.A.; Riaz, N.; Aborode, A.T.; Siddique, F.; Altwaijry, N.;  Al-Kahtani, H.M.; et al. Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies. Biomolecules 2022, 12, 1612.
23. S Rasheed, M Aziz, A Saeed, S Ejaz, P AChannar, S Zargar, Q Abbas, H Alanazi, M Hussain, M G. Alharbi, S J Kim, T A. Wani, H Raza. Analysis of 1-aroyl-3-(3-chloro-2-methylphenyl) thiourea hybrids as potent urease inhibitors: Synthesis, biochemical evaluation and computational
    approach. International Journal of molecular sciences, October 2022.
24. Saeed A, Ejaz SA, Khalid A, Channar PA, Aziz M, Wani TA, Zargar S, Hassan S, Ismail H, Khalid D, Hashmi MZ, Hökelek T and Aborode AT ( Sep 2022), Facile synthesis, crystal structure, biological evaluation, and molecular modeling studies of N-((4-acetyl phenyl) carbamothioyl) pivalamide as the multitarget-directed ligand. Front. Chem. 10:992701. doi: 10.3389/fchem.2022.992701.
25. Ahsan F, Mahmood T, Wani TA, Zargar S, Siddiqui MH, Usmani S, Shamim A, Wahajuddin M. Effectual Endeavors of Silk Protein Sericin against Isoproterenol Induced Cardiac Toxicity and Hypertrophy in Wistar Rats. Life. 2022 Jul 15;12(7):1063.
26. Aziz M, Ejaz SA, Zargar S, Akhtar N, Aborode AT, A Wani T, Batiha GE, Siddique F, Alqarni M, Akintola AA. Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer. Molecules. 2022 Jan;27(13):4098.
27. Salman Alamery, Seema Zargar, Fatimah Yaseen, Tanveer A. Wani  and Abdulaziz Siyal. Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice. Life 2022, 12, 900. https://doi.org/10.3390/ life12060900.
28. Arwa I A. Khayyat, Seema Zargar, Tanveer A. Wani, Muneeb U. Rehman, Azmat Ali Khan. Association Mechanism and Conformational Changes in Trypsin on Its Interaction with Atrazine: A Multi-Spectroscopic and Biochemical Study with Computational Approach. Int. J. Mol. Sci. 2022, 23, 5636. https://doi.org/10.3390/ijms23105636
29. Seema Zargar, Tanveer A.Wani, Nawaf A. Alsaif and Arwa Ishaq A. Khayyat. A Comprehensive Investigation of Interactions between Antipsychotic Drug Quetiapine and Human Serum Albumin Using Multi-Spectroscopic, Biochemical, and Molecular Modeling Approaches. Molecules. 2022, 27, 2589

Seema Zargar, Tanveer A Wani. Protective Role of Quercetin in Carbon Tetrachloride Induced Toxicity in Rat Brain: Biochemical, Spectrophotometric Assays and Computational Approach. Molecules. 2021, 26, 7526. https://doi.org/10.3390/molecules26247526 Q2

Seema Zargar, Tanveer A Wani. Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and computational approach (2021). Chemico-Biological Interactions. Q1

Tanveer Wani, Nawaf.Alsaif, Mohammed Alanazi, Ahmed .Bakheit, Azmat Ali Khan, Seema Zargar (2021).  Binding of colchicine and ascorbic acid (vitamin C) to bovine serum albumin: An in-vitro interaction study using multispectroscopic, molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids.  Q1

Ajaz Ahmad, Atif Zafar, Seema Zargar, Arwa Bazgaifan, Tanveer A Wani, Masood Ahmad (2021). Protective effects of apigenin against edifenphos-induced genotoxicity and cytotoxicity in rat hepatocytes. Journal of Biomolecular Structure and Dynamics. IF 3.31

Tanveer A. Wani, Ahmed H. Bakheit Abdulrahman, A. Al-Majed Nojood Altwaijry Anwar Baquaysh, Ashwaq Aljuraisy, Seema Zargar (2021). Binding and drug displacement study of colchicine and bovine serum albumin in presence of azithromycin using multispectroscopic techniques and molecular dynamic simulation.

Journal of Molecular Liquids. IF 6.16 Q1

Tanveer A. Wani, Nawaf Alsaif, Mohammed M. Alanazi, Ahmed H. Bakheit, Seema Zargar, Mashooq A. Bhat (2020). A potential anticancer dihydropyrimidine derivative and its protein binding mechanism by multispectroscopic, molecular docking and molecular dynamic simulation along with its in-silico toxicity and metabolic profile. European Journal of Pharmaceutical Sciences IF 4.384 Q2

TA.Wani, AH.Bakheit, Seema Zargar, Z Alanazi, A.Al-Majed (2020). Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 246:118977. Q1 IF 4.098.

S Zargar, S Alamery, AH Bakheit, TA Wani. (2020) Poziotinib and bovine serum albumin binding characterization and influence of quercetin, rutin, naringenin and sinapic acid on their binding interaction. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 235; 118335

TA Wani, AH Bakheit, Seema Zargar, H. Rizwana, A Al-Majed (2020). Evaluation of competitive binding interaction of neratinib and tamoxifen to serum albumin in multidrug therapy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Q1.
TA Wani, AH Bakheit, Seema Zargar……..(2020) Study of binding mechanism of dapoxetine with Calf Thymus DNA by spectroscopic, thermodynamic techniques and molecular docking. South African journal of chemistry. Accepted.
Seema Zargar, Mona Alonazi, Humaira Rizwana, Tanveer A. Wani (2019) Resveratrol reverses thioacetamide-induced renal assault with respect to oxidative stress, renal function, DNA damage and cytokine release in Wistar rats. Oxidative Medicine and Cellular Longevity. Article ID 1702959. Q2
TA Wani, AH Bakheit, Seema Zargar, MA Bhat, AA Al-Majed. (2019) Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin. Bioorganic chemistry 89, 103010. Q1
AA Al-Mehizia, AH Bakheit, Seema Zargar, MA Bhat, MM Asmari, TA Wani (2019) Evaluation of Biophysical Interaction between Newly Synthesized Pyrazoline Pyridazine Derivative and Bovine Serum Albumin by Spectroscopic and Molecular Docking Studies. Journal of Spectroscopy; Article ID 3848670. Q3
Nouf Alsalman, Abdulaziz Aljafari, Tanveer A. Wani, Seema Zargar (2019). High-dose aspirin reverses tartrazine-induced cell growth dysregulation independent of p53 signaling and antioxidant mechanisms in rat brain. Biomed Research International; Article ID 9096404. Q2
Tanveer A Wani, Ahmed H Bakheit, Mohammed Nazam Ansari, Abdul-Rahman A Al-Majed, Bakr M Al-Qahtani, Seema Zargar (2018). Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast. Drug Design Development and Therapy 12; 2627—2634.   Q2
Seema Zargar, AA TA Aljafari, Wani (2018).  Variants in MEF2A gene in relation with coronary artery disease in Saudi population. 3 Biotech. Jul;8(7):289. doi: 10.1007/s13205-018-1312-1. Q3
Seema Zargar, A A. Al-Majed and Tanveer A. Wani (2018). Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice. BMC Complement Altern Med. 2018 Mar 23; 18(1). 106.  Q1
T A Wani, AH Bakheit, MA Abounassif, Seema.Zargar (2018). Study of Interactions of an Anticancer Drug Neratinib with Bovine Serum Albumin: Spectroscopic and Molecular Docking Approach. Front Chem. 2018 Mar 7; 6:47. Q2
Asma Alkaf, Abdulaziz Al-Jafari, T A. Wani, S Alqattan, Seema Zargar (2017). Expression of STK11 gene and its promoter activity in MCF control and cancer cells. 3 Biotech 7:362. DOI 10.1007/s13205-017-1000-6.
Tanveer A Wani*, Seema Zargar, Mohammed A. Hamidaddin,Ibrahim A. Darwish. Spectrophotometric and molecular modelling studies on in vitro interaction of tyrosine kinase inhibitor linifanib with bovine serum albumin. Plosone. Published:April18,2017.  https://doi.org/10.1371/journal.pone.0176015.
T A. Wani , AH. Bakheit , A Al-Majed, MA Bhat  and Seema Zargar. Study of the Interactions of Bovine Serum Albumin with the New Anti-Inflammatory Agent 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(4-ethoxy-phenyl)methylidene]benzohydrazide Using a Multi-Spectroscopic Approach and Molecular Docking. Molecules 2017, 22(8),1258; doi:10.3390/molecules22081258. 
Seema Zargar, T A. Wani, A A Alamro, MA Ganaie. (2017). Amelioration of Thioacetamide Induced Liver Toxicity in Wistar Rats by Rutin.   
Seema Zargar , N J Siddiqi, S Ansar, M Alsulaimani & A. El ansary (2016). Therapeutic role of quercetin on oxidative damage induced by acrylamide in rat brain. Pharmaceutical Biology.
T A. Wani and Seema Zargar (2015). New ultra-performance liquid chromatographytandem mass spectrometry method for the determination of irbesartan in human plasma. Journal of food and drug analysis.  2 3; 5 6 9 -5 7 6.
Seema Zargar, T. A. Wani, S. K. Jain. (2015). Identification of Putative Vero Cell Protein(s) that Bind Specifically to Recombinant Envelope Protein of Dengue Virus Type 2. Tropical journal of Pharmaceutical Research. 14,(6) 997-1003.
T A. Wani , A.M. Alanazi, Seema Zargar, A. Ahmad, I. Darwish (2015). Box–Behnken Design Based Statistical Modelling for Optimization of UPLC-MS/MS Method for Analysis of Sorafenib in Bulk and Tablets. Journal of Computational and Theoretical Nanoscience. 12, 3598–3604.
T A. Wani and Seema Zargar (2015). New Highly-Sensitive Ultra-Performance Liquid Chromatography - Mass Spectrometry Method for Quantification of Telmisartan in Human Plasma. TJPR 14 (3): 511-518.
Seema Zargar, N JSiddiqi, S Al Daihan, TA. Wani. (2015) Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver. Acta biochimica polonica 62(2) 207-213.
Tanveer A. Wani, Seema Zargar and Ajaz Ahmad. Ultra Performance Liquid Chromatography Tandem Mass Spectrometric Method Development and Validation for Determination of Neratinib in Human Plasma. S. Afr. J. Chem., 2015, 68, 93–98
N JSiddiqi and  Seema Zargar (2015).. Quercetin protects mice kidney collagen against the damage induced by cadmium fluoride. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.
TA Wani and Seema Zargar. (2014).Sensitive UPLC-tandem mass spectrometric method for determination and validation of hydrochlorthiazide in human plasma. Lat. Am. J. Pharm, accepted on nov 21/ 2014.
Seema Zargar. (2014). Inhibitory effect of various aqueous medicinal plant extracts production and fungal biomass by Penicillium notatum and Aspergillus niger. IAIM. 1(3): 1-8.
Seema Zargar, NJ Siddiqi, TH Khan, IE Elredah. (2014). Effect of cadmium fluoride and quercetin on in vivo activity of indoleamine 2,3-dioxygenase in mice liver and kidney. Fluoride. 47(1): 31–42.
NJ Siddiqi and Seema Zargar (2014). Effect of quercetin on cadmium fluoride induced alterations in hydroxyproline/collagen content in mice liver. Connective tissue research. 55(3): 234-238.
Seema Zargar and TA Wani. (2014). Ultra-performance liquid chromatography/tandem mass spectrometry method for simultaneous determination of irbesartan and hydrochlorthiazide in human plasma. Accepted in Journal of the Iranian Chemical Society. DOI 10.1007/s13738-014-0429-3
Seema Zargar and T A. Wani. (2014). New UPLC-MS/MS method  for simultaneous determination of telmisartan and  hydrochlorthiazide in human plasma. Lat. Am. J. Pharm, 33(3);432-40.
Seema zargar. (2014). Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences.
TA Wani and Seema Zargar (2015). Statistical modelling for optimization of automated spectrophotometric assay for determination of cefadroxil in its pharmaceutical formulations. Accepted in Lat. Am. J. Pharm
Tanveer A. Wani, Muzaffar Iqbal, Ibrahim Darwish Nasr Y. Khalil, Seema Zargar.(2014) Development and validation of sensitive uplc-ms/ms based method for the estimation of crizotinib in human plasma. Digest Journal of Nanomaterials and Biostructures. 9:693-704.
Perwez Alam, Mohammad S. Ahmad, Tanveer Ahmad Wani, Seema Zargar and Nasir A. Siddiqui.(2014).  Simultaneous quantification of two bioactive flavonoids Homoeriodictyol and Persicogenin in the methanol extract of aerial parts of two different species of genus Rhus by validated HPTLC densitometric method. Accepted in Journal of Planar Chromatography - Modern TLC October 2014. Manuscript No. JPC528R1
Seema zargar, S. wakil, A.  mobeirek, A. al‑jafari. (2013). Involvement of ATP‑binding cassette, subfamily A polymorphism with susceptibility to coronary artery disease. Biomedical Reports:, 883-888.
Darwish I A., Wani TA., Alanazi AM., Hamidaddin MA., Seema Zargar. (2013) Kinetic-exclusion analysis-based immunosensors versus enzyme-linked immunosorbent assays for measurement of cancer markers in biological specimens. Talanta. 111, 13-19.
S. Al-Daihan, M. Al-Faham, N. Al-shawi, R. Almayman, A. Brnawi, Seema zargar R. S. Bhat. (2013). Anti-microbial activity of zingier officinal and curcum longa extracts against some selected micro-organisms. Journal of King Saud University - Science, April, Volume 25, Issue 2, Pages 115-120.
T. A. Wani, A. Ahmad, Seema Zargar, Nasr Y. Khalil, Ibrahim A. (2012). Darwish. Use of response surface methodology for optimization and validation of new microwell-based spectrophotometric method for determination of atorvastatin calcium in tablets.  Chemistry Central Journal., 6:134 doi:10.1186/1752-153X-6-134.
Seema Zargar, Tanveer A. Wani, S. K. Jain. (2011). Morphological changes in vero cells postinfection with dengue virus type-2. Microscopy Research and Techniques.  74, 314-319.
T. A. Wani, M. Al-Omar, Seema Zargar. Huntington Disease: Current A dvances in Pathogenesis and Recent Therapeutic Strategies. International Journal of Pharmaceutical Sciences and Drug Research.  2011; 3(2): 69-79.
Seema zargar and S. K. Jain. (2008). Published several sequence in Uniprot KB/Swiss-Prot entry under accession no. p84856, p694580.
Seema and S.K.Jain, (2005). Molecular mechanism of pathogenesis of dengue virus: Entry and fusion with target cell. Ind. Jour. Clin. Biochem., 20 (2) 92-103. 
Book Chapters:
Colchicine induced ion channel formation into membranes as mechanism behind chemotherapy drug cytotoxicity of cancer cells. (2019) A. Alqarni, Seema Zargar, M. Ashrafuzamman. Chapter V, 151-189.Lipid bilayers. Nova medicine and health, New York.
Transcription and its regulation. (2017) Seema Zargar and Tanveer Ahmad Wani. Chapter II, 19-30. Quick Revision of Molecular Biology. Research India Publications. India. 

CONFERENCES AND WORKSHOPS:

1. Oral speaker  Genomic approach in treatment of viral diseases. in Genomics and Precision medicine Uk
2. Poster in American chemical society.
3. Seema and S.K. Jain. Proteomic approach for characterization of cell surface receptors for dengue virus: protein profile of permissive and non-permissive cells. Biotechnology and Human welfare magazine. 2006. Hamdard University. New Delhi.
4. Seema and Jain S. K. proteome profile of permissive and non-permissive cells for different serotypes of dengue virus. 33rd immunological society  proceedings. 2004, 341-342.
5. Attended Interdisciplinary Science Conference on Recent Trends in Research in Biological Sciences.
6. Attended National Conference on Electron Microscopy and Allied Fields and XXIX Annual Meeting of EMSI.

  REVIEWER 
Reviewer to Journal of Infectious disease and immunity, Intervirology, Indian journal of Biological Sciences, Hindawi publishing systems,Science international, JBC, J of mol liquids, molecules, J. of Molecular dynamics and many more
 MEMBERSHIPS: 
Member of European Federation of Biotechnology. 
Member of Indian Immunological society 

PERSONAL DETAILS:

Gender                                               :           Female
 Marital Status                                    :           Married
 Hobbies                                             :           Travelling, & Internet surfing.
 Nationality                                          :           Indian
 Permanent Address                         :           House No.19, Ahmadnagar , Srinagar , Kashmir, India -190006
   
 
 
Seema Zargar