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سليمان يوسف عبدالرحمن العمر

Associate Professor

أستاذ مشارك علم مناعة الاورام

كلية العلوم
مبنى 4 / مبنى 5: AB104
publication
Journal Article
2011

Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer

, 50. Al Omar, S. Y., Marshall, E., Middleton, D., & Christmas, S. E. . 2011

(Impact factor =3.7–Q2).

Frequencies of natural killer (NK) cells from patients with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) did not differ from healthy controls. A higher proportion of NK cells from NSCLC patients expressed the killer immunoglobulin-like receptor (KIR) CD158b than in controls (P = 0.0004), in the presence or absence of its ligand, HLA-C1. A similar result was obtained for CD158e in the presence of its ligand HLA-Bw4 in NSCLC patients (P = 0.003); this was entirely attributable to the Bw4I group of alleles in the presence of which a fivefold higher percentage of CD158e(+) NK cells was found in NSCLC patients than controls. Proportions of CD158b(+) NK cells declined with advancing disease in NSCLC patients. Expression of NKp46, CD25 and perforin A, and production of interferon-γ following stimulation with interleukin-12 and interleukin-18, were all significantly lower in NK cells from NSCLC patients than in controls. Both NK cell cytotoxicity and granzyme B expression were also reduced in lung cancer patients. Increased inhibitory KIR expression would decrease NK cell cytotoxic function against tumour cells retaining class I HLA expression. Furthermore, the reduced ability to produce interferon-γ would restrict the ability of NK cells to stimulate T-cell responses in patients with lung cancer.

Publication Work Type
بحث
Volume Number
1
Issue Number
133
Magazine \ Newspaper
Immunology
Pages
94-104
more of publication
publications

Frequencies of natural killer (NK) cells from patients with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) did not differ from healthy controls.

by 50. Al Omar, S. Y., Marshall, E., Middleton, D., & Christmas, S. E.
2011
publications

CD56+ T cells were studied in samples of peripheral blood from small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) patients compared with healthy controls.

by 48. Al Omar, S. Y., Marshall, E., Middleton, D., & Christmas, S. E.
2012
publications

These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.

by . Al Omar S, Flanagan BF, Almehmadi M, Christmas SE
2013