Engineering cord blood T cells for tumour immunotherapy

Conference Paper

2013

Published in: Engineering cord blood T cells for tumour immunotherapy

Alsubki, Roua . 2013

Engineering Cord Blood T cells
Cord blood T cells (CB-T cells) have a naïve phenotype and mediate potent antiviral and anti-leukaemia effects following allogeneic transplantation with reduced graft versus host disease compared to peripheral blood grafts.  Can these cells be engineered for directed anticancer therapies?

Aims:-1- Define conditions for lentiviral mediated antigen specific receptor transfer to cord blood T cell. 2-Disrupt endogenous α/β TCR expression to reduce off target effects or alloreactivity

• Publication Work Type: Conference paper
• Conference Location: Cell and gene therapy
• Conference Name: British Society of cell and Gene therapy
• Sponsoring Organization: BSCG