Engineering cord blood T cells for tumour immunotherapy
Alsubki, Roua . 2013
Engineering Cord Blood T cells
Cord blood T cells (CB-T cells) have a naïve phenotype and mediate potent antiviral and anti-leukaemia effects following allogeneic transplantation with reduced graft versus host disease compared to peripheral blood grafts. Can these cells be engineered for directed anticancer therapies?
Aims:-1- Define conditions for lentiviral mediated antigen specific receptor transfer to cord blood T cell. 2-Disrupt endogenous α/β TCR expression to reduce off target effects or alloreactivity
This study mainly aims to evaluate the design of immunity based on genetics, this includes the following sub- objectives; first: to identify the complex regulation of immunity, and the cause of…
Engineering Cord Blood T cells
Cord blood T cells (CB-T cells) have a naïve phenotype and mediate potent antiviral and anti-leukaemia effects following allogeneic transplantation with…