Ahmad Aboragah

Assistance Professor

Reproduction Physiology in Ruminant Animal 

Department of Animal Production

Food and Agriculture Collage

King Saud University

Tel. 0558314490

aaboragah@ksu.edu.sa

Education:

• King Saud University, College of Food Science and Agriculture

Bachelor of Agricultural Science: June 2012, GPA 3.87/5.00, Animal Production

• Southern Illinois University, College of Agricultural Sciences

      Master of Animal Science: Program completed May 2019 GPA 3.71/4.00

                  Thesis: Sonication to improve Date palm seeds degradability in Rumen

• University of Illinois, College of Animal Science

Ph.D. of Animal Science: Program completed Dec 2022 GPA 3.64/4.00

Thesis: Molecular and biochemical analyses of the role of nutrition and body condition in 

            Holstein cows and the developing fetus

Memberships:

• Co-member of Animal production in Food and Agriculture college at KSU since 2023.
• Co-member of the Biodiversity program for graduate students at KSU since 2023.
• Co-member of the Alumni Affairs Unit Council at KSU since 2024.
• Co-member of the Food and Agriculture College graduate program at KSU since 2024.
• Co-member of the Saudi Student Society at the University of Illinois Urbana- Champaign in 2021.
• Co-member of the Saudi Student Society at the University of Nebraska-Lincoln in 2014.
• Co-member of the Advisory Board at King Saud University in 2011.

Teaching Experience:

• Teaching course Introduction of Animal Production at KSU (ANPR 200).
• Teaching course Reproduction in ruminant animals at KSU (ANPR 388).
• Teaching course Advanced sheep production at KSU (ANPR 561).
• Teaching course research and discussion at KSU (ANPR 468).

Research and Laboratory Experience:

• Two months intensive training in NADEC Dairy Company in Saudi Arabia in 2010.
• Neutral detergent fiber (NDF) and Acid detergent fiber (ADF) analyzes by ANKOM 200.
• Acid detergent lignin analyzes by ANKOM technology method.
• Crude protein (CP) contents by LECO FP-528.
• Crude lipid analyzes by ANKOM ^x10 Extractor.
• Ash contents by Thermo scientific furnace.
• Measuring digestibility by Situ method by Dacron bags.
• Ultrasonic processor by (Ultrasonic Processor FS-900N).
• RNA extraction and analysis.
• Western Blot extraction and analysis.
• Enzyme assay extraction and analysis.

Workshops attendance:

• A training course entitled Evaluation of Learning Outcomes and Electronic Tests for Faculty Members by King Saud University in 2024.
• A training course entitled Evaluation of Learning Outcomes and Electronic Tests for Faculty Members by King Saud University in 2024.
• A training course entitled Using Modern Technologies in Teaching for Faculty Members by King Saud University in 2024.
• A training course entitled Microteaching and Peer Consultation for Faculty Members by King Saud University in 2024.
• A training course entitled Effective University Teaching for Faculty Members by King Saud University in 2024.
• A training course entitled Preparing for a Review Team Visit for Faculty Members by King Saud University in 2024.
• A training course entitled Designing and Building a Curriculum for Faculty Members by King Saud University in 2024.
• A training course entitled Preparing a Self-Study for Faculty Members by King Saud University in 2023.
• A training course entitled Program Description and Report for Faculty Members by King Saud University in 2023.
• A training course entitled Curriculum Description and Report for Faculty Members by King Saud University in 2023.
• A training course entitled Key Quality Questionnaires and Benchmarking for Faculty Members by King Saud University in 2023.
• A training course entitled Quantitative and Qualitative Analysis of Data and Preparing Statistical Reports for Faculty Members by King Saud University in 2023.
• A training course entitled Evaluation of Educational Outcomes of Programs and Courses for Faculty Members by King Saud University in 2023.
• A training course entitled Skills for Formulating and Applying Education Outcomes for Faculty Members by King Saud University in 2023.
• A training course entitled Program Accreditation Standards for Faculty Members by King Saud University in 2023.
• Working with livestock in agricultural research environments by Southern Illinois University in the United States of America in 2018.
• Computer skills development course for teaching assistants and lecturers at King Saud University in 2011.
• English language skills development course for teaching assistants and lecturers at King Saud University in 2011.
• Introductory workshop on using databases and how to search them in 2011.
• Guideline initiative for preparatory year students in 2011.
• Mechanism for selecting students for university councils in 2011.

Certifications:

• English and Computer Skills, King Saud University, 2012.
• Intensive English training at the University of Nebraska-Lincoln, 2014.
• Environmental condition on physiological and molecular responses of goats, King Saud University, 2015.
• Advanced English program, Southern Illinois University, 2017.
• Beef Quality Assurance certification, Southern Illinois University, 2018.
• Institutional Animal Care and Use Committee, Southern Illinois University, (2018-2022).

Extra-curricular activities:

• Al-Hilal squash team & Saudi Federation squash team

      Publication:

• Aboragah, A. A., Wichasit, N., Alharthi, A. A., Alhidary, I. A., & Loor, J. J. (2024). Alterations in one‑carbon metabolism and protein synthesis signals due to methionine supplementation and lipopolysaccharide challenge in Holstein fetal liver explants. Research in Veterinary Science, 105386
• Aboragah, A., Alharthi, A., Wichasit, N., Loor, J. Body condition prepartum and its association with term placentome nutrient transporters, one-carbon metabolism pathway activity, and intermediate metabolites in Holstein cows. Veterinary Sciences. July 2023.
• Aboragah, A., Sherlock, D., Wichasit, N., Loor, J. Abundance of proteins and genes associated with nutrient signaling, protein turnover, and transport of amino acids and glucose in fetuses from lactating Holstein cows. Veterinary Sciences. June 2023.
• Aboragah, A., Embaby, M., Günal, M., & Abughazaleh, A. (2019). Effect of alkaline and sonication pretreatments on the rumen degradability of date palm seeds. Tropical Animal Health and Production, 52(2), 771–776. doi: 10.1007/s11250-019-02068-w
• Aboragah, A., Embaby, M. G M., Günal, M., & Abughazaleh, A. A. (2019). The Effect of Ultrasound Processing and Exogenous Cellulase Supplementation on the Ruminal Degradability of Palm Date Seeds. American Journal of Animal and Veterinary Sciences, 14(3), 176–182. doi: 10.3844/ajavsp.2019.176.182.
• Alhidary, I. A., Al-Baadani, H. H., Alharthi, A. S., & Aboragah, A. A. (2024). The effects of varied neutral detergent fiber levels on blood parameters, nutrient digestibility, rumen fermentation characteristics and rumen tissue morphology in lambs. Indian Journal of Animal Research, Of. https://doi.org/10.18805/ijar.bf-1860.
• Jiang, Q., Galvão, M. C., Thanh, L. P., Aboragah, A. A., Mauck, J., Gionbelli, M. P., & Loor, J. J. (2024). Short-term feed restriction induces inflammation and an antioxidant response via cystathionine-β-synthase and glutathione peroxidases in ruminal epithelium from Angus steers. Journal of Animal Science, skae257.
• Coleman, D. N., Jiang, Q., Lopes, M. G., Ritt, L., Liang, Y., Aboragah, A., ... & Loor, J. J. (2023). Feeding a Saccharomyces cerevisiae fermentation product before and during a feed restriction challenge on milk production, plasma biomarkers, and immune function in Holstein cows. Journal of animal science, 101, skad019.
• R.E. Bucktrout, N. Ma, A. Aboragah, A.S. Alharthi, Y. Liang, V. Lopreiato, M.G. Lopes, E. Trevisi, I.A. Alhidary, C. Fernandez, J.J. Loor, (2021). One-carbon, carnitine, and glutathione metabolism-related biomarkers in peripartal Holstein cows are altered by prepartal body condition, Journal of Dairy Science,Volume 104, Issue 3, 2021
• Shi, Z., Song, Y., Gao, X., Loor, J. J., Aboragah, A., Yu, H., Fang, Z., Zhu, Y., Du, X., Li, X., Gao, W., & Liu, G. (2021). Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows. Journal of dairy science, 104(8), 9130–9141.
• Li, M., Yang, W., Wen, J., Loor, J. J., Aboragah, A., Wang, J., Zhang, B. (2021). Intracellular Ca2+ signaling and ORAI calcium release-activated calcium modulator 1 are associated with hepatic lipidosis in dairy cattle. Journal of Animal Science, 99(7), skab184.
• Zhang, H., Shen, Z., Yang, Z., Jiang, H., Chu, S., Mao, Y., Yang, Z. (2021). Abundance of solute carrier family 27 member 6 (SLC27A6) in the bovine mammary gland alters fatty acid metabolism. Food & Function.
• Wang, L., Juan, L., Aboragah, A., Jiang, M., & Loor, J. J. (2021). Metagenomic analysis reveals rumen microbiota alteration of the yak at different stages of growth.
• Shen, T., Li, X., Jin, B., Loor, J. J., Aboragah, A., Ju, L.,  Zhu, Y. (2021). Free fatty acids impair autophagic activity and activate nuclear factor kappa B signaling and NLR family pyrin domain containing 3 inflammasome in calf hepatocytes. Journal of Dairy Science, 104(11), 11973–11982.
• Liu, L., Lu, H., Loor, J. J., Aboragah, A., Du, X., He, J., Liu, G. (2021). Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells. Journal of Dairy Science, 104(12), 12871–12880.
• Lei, L., Gao, W., Loor, J. J., Aboragah, A., Fang, Z., Du, X., Li, X. (2021). Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of β-hydroxybutyrate in bovine hepatocytes. Journal of Dairy Science, 104(12), 12845–12858.
• Chen, Z., Liang, Y., Lu, Q., Nazar, M., Mao, Y., Aboragah, A., Loor, J. J. (2021). Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland. Ecotoxicology and Environmental Safety, 222, 112477.
• Cui, Y., Wang, Q., Chang, R., Aboragah, A., Loor, J. J., & Xu, C. (2021). Network Pharmacology-Based Analysis of Pogostemon cablin (Blanco) Benth Beneficial Effects to Alleviate Nonalcoholic Fatty Liver Disease in Mice. Frontiers in Pharmacology, 12.
• Dong, J., Yue, K., Loor, J. J., Aboragah, A., Li, G., Chen, L., Wang, Z. (2022). Increased adipose tissue lipolysis in dairy cows with fatty liver is associated with enhanced autophagy activity. Journal of Dairy Science.
• Chen, Y., Tang, Y., Luo, S., Jia, H., Xu, Q., Chang, R., & Sun, X. (2021). Nuclear factor erythroid 2-related factor 2 protects bovine mammary epithelial cells against free fatty acid-induced mitochondrial dysfunction in vitro. Journal of Dairy Science, 104(12), 12830-12844.
• Shi, Z., Song, Y., Gao, X., Loor, J. J., Aboragah, A., Yu, H., Fang, Z., Zhu, Y., Du, X., Li, X., Gao, W., & Liu, G. (2021). Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows. Journal of dairy science, 104(8), 9130–9141.
• Wang, L., Juan, L., Aboragah, A., Jiang, M., & Loor, J. J. (2021). Metagenomic analysis reveals rumen microbiota alteration of the yak at different stages of growth.

Conference posters participation:

• Profiles of nutrient signaling, protein turnover, and one-carbon metabolism-related proteins and intermediate metabolites in tissues from Holstein fetuses at mid-gestation (Abstract annual meeting in Kansas City, MO (June, 2022).
• Abundance of genes associated with nutrient signaling, protein turnover, and one-carbon metabolism in tissue from Holstein fetuses at mid-gestation (Abstract annual meeting in Kansas city, MO (June, 2022).
• Alterations in one-carbon metabolism due to Methionine supplementation and lipopolysaccharide challenge in Holstein fetal liver explants (2021) A. Aboragah*, Y. Liang, D. N. Coleman, J. J. Loor; University of Illinois, Urbana, IL, 61801, USA. (Abstract annual meeting will be in Louisville, Ky, (June, 2021).
• Body condition prepartum and its association with placentome nutrient transport, one-carbon metabolism, and amino acid utilization in Holstein cows. A. Aboragah*¹, A. Alharthi^1,2, V. Lopreiato², Y. Liang¹, J. J. Loor¹; ¹University of Illinois, Urbana, IL, 61801, USA, ²King Saud University, Riyadh, 11451, Saudi Arabia, ³Università Cattolica del Sacro Cuore, Piacenza, 29122, Italy. (Abstract annual meeting will be in Louisville, Ky, (June, 2021).
• The Rumen Degradability of Palm Date Seeds When Treated with Sodium Hydroxide and Ultrasound Processing. (Abstract annual meeting in Cincinnati, OH (June, 2019).
• The Effect of Ultrasound Processing and Exogenous Cellulase supplementation on the Ruminal Degradability of Palm Date Seeds. (abstract annual meeting in Cincinnati, OH (June, 2019).
• One-carbon metabolism and nutrient transporters in the gastrointestinal tract of lactating Holstein cows. Q. Jiang, D.N Coleman,, Y.Liang, A, Aboragah, J.J. Loor; Department of Animal Sciences, University of Illinois, Urbana, 61801(Abstract annual meeting in Cincinnati, OH (June, 2021).
• Ileal microbiota profiles during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation products Q. Jiang , D.N Coleman,, Y.Liang, A, Aboragah, A, Elolimy, M. Vailati-Riboni, I. Yoon, J.J. Loor; Department of Animal Sciences, University of Illinois, Urbana, 61801(Abstract annual meeting in Kansas city, MO (June, 2022).
• Antioxidant mechanisms in ruminal epithelium respond to feed restriction. Q. C. Galvao, A.Aboragah, Q. Jiang, N. Wichasit, L.P. Thanh, J.C. McCann, J. J. Loor  (Abstract annual meeting in Kansas city, MO (June, 2022).

د. سعد بن سعيد يحيى الزهري الغامدي
الرئيس الأسبق لجمعية السعودية للمكتبات والمعلومات؛ وللاتحاد العربي للمكتبات والمعلومات؛ ولجمعية المكتبات المتخصصة في الخليج العربي

- حاصل على درجة الدكتوراه في علم المعلومات بامتياز في قسم علم المعلومات بجامعة الملك عبدالعزيز

- حاصل على جائزة أفضل رسالة علمية في الوطن العربي في المجال لعام 2009 من الاتحاد العربي للمكتبات والمعلومات

- حاصل على درجة الماجستير في جامعة إنديانا الأمريكية Indiana University/SLIS

- الرئيس الأسبق للاتحاد العربي للمكتبات والمعلومات(اعلم)

- الرئيس الأسبق لجمعية المكتبات المتخصصة بالخليج العربي
- مدير تحرير مجلة اعلم العلمية المحكمة
- عضو تحرير ثلاث دوريات علمية محكمة في الوطن العربي
- عضو مكتب تنفيذي=منظمة حواسيب المكتبات OCLC- مجلس أوربا وأفريقيا والشرق الأوسط 2008-2011

- له العديد من البحوث وثلاثة كتب

- حضر أكثر من ستين مؤتمرا محليا وعربيا وعالميا

- حضر أكثر من خمسين ورشة عمل تدريبية

- قدم أكثر من ستين ورشة عمل في المجال وفي التطوير الذاتي محليا وخليجيا وعربيا

Untitled document

Curriculum Vitae

Dr. Abdulrahman A. Al-Majed
Professor
Department of Pharmaceutical Chemistry, College of Pharmacy,
King Saud University, P.O. Box 2457, Riyadh-11451
Kingdom of Saudi Arabia.
Tel. (Office): ++ 966 1 4777347
Fax: ++966 1 4676220
Email: almajed99@yahoo.com

Personal Information:

Date of Birth: 01/06/1967
Place of Birth: Riyadh, Saudi Arabia.
Nationality: Saudi
Sex: Male
Marital Status: Married and have four children

Education Background:

• Bachelor of Pharmaceutical Sciences from College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
(1990 1991).
• Ph.D. in Pharmaceutical Chemistry from University of Bradford, United Kingdom.
(1998).

• Bachelor of Legislation from College of Legislation, Imam Mohammed Bin Saud Islamic University, Riyadh, Saudi Arabia.
(2003).

Employment History:

(1991-1993) Teaching Assistant, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

(1993-1998) Obtained the degree of Doctor of Philosophy from the United Kingdom with the purpose of becoming a staff member in the department.

(1998-2003) Assistant Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

(2003-2009) Associate Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

(2009-Till Now) Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Administrative Assignments:

(2005-2009) Chairman, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

(2009-Till now) Assistance Secretary of Scientific council, King Saud University.

Participation in Committees, Councils and Societies

A. Committees and Councils:

1. 1998- Member of the Interviewing Committee for the Students who apply for the admission, in the College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

2. 1998- Member of the Committee for Chemicals and Equipments in the Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

3. 1998-2005 Head of the Educational and Social Activities Committee, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

4. 1990-2000 Member of the Written Exam Committee for the Students who apply for the admission, in the College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

5. 1999-2000 Member of the Final Examination Committee of the Second Semester in the College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

6. 1999-2001 Secretary for the Departmental Meetings.

7. 2000-2002 Chairman of the Committee for Data Base in Saudi Pharmaceutical Society, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

8. 2000-2005 Member of the Academic Committee, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

9. 2000- Member of the University and the College Society, King Saud University, Riyadh, Saudi Arabia

10. 2003- Member of the Chemical Pollution Protection Committee, King Saud University, Riyadh, Saudi Arabia

11. 2006- Member of the Permanent Interviewing Committee for Employment, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

12. 2006- Member of the Committee for the Health Education, College of Pharmacy, Project (AFAQ) and the Future Higher Education (Future Plan for the Universities in the Kingdom of Saudi Arabia).
13. 2008- Member of post graduate studies committee, King Saud University, Riyadh, Saudi Arabia

B. Professional and Honor Societies:

1. 1998- Member of the Housing Club Committee for the Teaching Staff.

2. 1999- Member of the Saudi Chemical Society, Riyadh, Saudi Arabia.

3. 1999- Member of the Cooperative Society King Saud University, Riyadh, Saudi Arabia.

4. 1990-Till Now Member of the Saudi Pharmaceutical Society, Riyadh, Saudi Arabia.

5. 2000- Member of the Anti-smoking Society.

6. 2000-2002 Member of the Administrative Committee at Saudi Pharmaceutical Society, Riyadh, Saudi Arabia.

7. 2002-2004 Member of the Administrative Council Housing Club Committee for the Teaching Staff.

8. 2006- Vice-Chairman of the Social Development Council for cultivation.

Conferences and Symposia:
1. “First National Symposium on Materials”, College of Science, King Saud University, 29th November to 2nd December 1998. A paper was presented entitled: “Volammetric Behavior and Determination of Nizatidine in its Dosage Forms and Biological Fluids.”
2. Pharmaceutical Sciences Conference organized by Saudi Pharmaceutical Society, held in Riyadh, October 1999. The following three articles were presented in the Conference:
a. The Voltammetric Study and Determination of Ramipril in Dosage Forms and Biological Fluids.
b. Determination of Terfenadine in Dosage Forms and Plasma.
c. Spectrophotometric Determination of Fenoterol HBr in Pharmaceutical Preparations.
3. “The Annual Symposium of Federation Analytical Chemistry Societies (FACSS)” held in Nasfield, United States, 24th September to 28th September 2000. A paper was presented entitled: “Fluorometric determination of gentamicin in dosage forms and biological fluids through derivatization with 4-chloro-7-nitrobenzo-2-ocxa-1,3-diazole (NBD-Cl).”
4. “The 6th Scientific Conference on Quality Control for Drugs, Vaccines and Natural Products” held in Cairo, Egypt, 23rd March to 25th March 2002. A paper was presented entitled: “Degradation Kinetics and Stability-indicating Assay of Nicardipine Hydrochloride.”
5. The 3rd International Pharmaceutical Conference, Dhahran, Kingdom of Saudi Arabia, 15th October to 17th October, 2002. Two papers were presented entitled: “Anodic Polarographic Method for Determination of Isradipine in Formulations and Biological Fluids.” And “Spectrofluorometric determination of Lisinopril in Pharmaceutical Preparaton Through Derivatization with Ninhydrin/Phenylacetaldehyde System.”
6. Pharmaceutical and Industrial Conference on “The Future View on the Third Century,” Chemistry Department, College of Science, King Saud University, Riyadh, 27th November to 1st December 2004. A paper was presented entitled: “Anodic Polarographic Determination of Josamycin in Formulations and Spiked Human Urine.”
7. Member of principle of Committee of the 9th International Pharmaceutical Science Conference and Exposition and the 9th General Assembly Meeting of the Scientific Society of Colleges of Pharmacy of the Association of Arab Universities in the Arab World, 17-21 December 2005, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
8. The New Zealand Institute of Chemistry Conference (NZIC 2006), “Back to the Basic from Small Molecules to Materials and Surfaces,” 2nd December to 6th December, 2006, Royal Lakeside Novotel, Roturaa, New Zealand.
9. National Conference in Chemistry 2007, 15th April to 16th April 2007, Saudi Chemical Society, Riyadh, Saudi Arabia. A paper was presented entitled: “A New Method for the Determination of Some Aminoglycosides Antibiotics by HPLC using 7 Fluoro-4-nitrobenz-2-oxa-1,3-diazole (NBD F) as a Fluorogenic Precolumn Label.”
10. The Royal Australian Chemical Institute, “Drug Discovery & Development”, 13/7/2008 to 17/7/2008, Couran cove Island Resort, The South Stradbroke Island, Australia.

List of Publications

1. A. A. Al-Majed, “Spectrophotometric estimation of D-penicillamine in bulk and dosage forms using 2,6-dichloroquinone-4-chlorimide (DCQ)”. Journal of Pharmaceutical and Biomedical Analysis, Belgium, 21 (199) 827-833.
2. A.A. Al-Majed; F. Belal; A.M. Al-Obaid and A. H. Daaoud, “Voltammetric Behavior and Determination Of Nizatidine in Biological Fluids”. Journal of Pharmaceutical and Biomedical Analysis, Belgium, 21 (1999) 319-326).
3. A. A. Al-Majed, F. Belal and A. A. Al-Badr, Analytical Profile of Diloxanide Furoate: A monograph in "Analytical Profile of Drug Substances and Excipients", Editor : H. G. Britain; Academic Press, New York. Vol. 26 (1999) 392-411.
4. F. Belal; O. A. Al-Deeb; A. A. Al-Majed and E. A. R. Gad-Kariem, “Voltammetric Determination of N-Nitrosoderivatives of Atenolol and Propranolol in Simulated Gastric Juice”. IlFarmaco, Italy, 54 (1999) 700-704.
5. F. Belal; A. A. Al-Majed, A. A. Al-Badr and H. I. El-Subbagh, Analytical Profile of Isoxsuprine. HCl: A monograph in "Analytical Profile of Drug Substances and Excipients", Editor: H. G. Britain; Academic Press, New York. Vol. 26 (1999) 359 393.
6. F. Belal; A. A. Al-Majed and A. M. Al-Obaid, “Methods Analysis of 4-Quinolone Antibacterials”. Talanta, USA, 50 (1999) 765-786.
7. A. A. Al-Majed; F. Belal and A. M. Al-Obaid, “The Voltammetric Study and Determination of Ramipril in Dosage Forms and Biological Fluids”. IlFarmaco, Italy, 54 (1999) 700-704.
8. A. Al-Majed, “Specific Spectrofluorometric quantification of D-penicillamine and its determination in bulk and dosage forms after derivatization with 4-fluoro-7-nitro-benzoxadiazole (NBD-F).” Analytica Chimica Acta, The Netherlands, 408 (2000) 169-175.
9. A. A. Al-Majed, J. Al-Zehouri and F. Belal, “Use Mixed Anydrides for the Determination of Terfenadine in Dosage forms and Spiked Human Plasma.” Journal of Pharmaceutical and Biomedical Analysis, 23 (2000) 281-289.
10. G. A. Al-Malaq, A. A. Al-Majed and F. Belal, “A stability-indicating spectrophotometric method for the determination of fenoterol in pharmaceutical preparations.” Analytical Letters, 33 (2000) 1961-1974.
11. F. Belal, H. A. Al-Malaq and A. A. Al-Majed, “Voltammetric determination of isoxsuprien and fenoterol in dosage forms and biological fluids through nitrosation.” Journal of Pharmaceutical and Biomedical Analysis, 23 (2000) 1005-1015.
12. F. Belal H. A. Al-Malaq, A. A. Al-Majed and E. A. Gadkariem, “A stability-indicating HPLC method for determination of isoxsuprine in dosage forms. Application to kinetic Studies of isoxsuprine”. Journal of liquid Chromatography and Related Technology, 23 (2000) 3175-3189.
13. A. A. Al-Majed, Analytical Profile of fenoterol: A monograph in "Analytical Profile of Drug Substances and Excipients", Editor: H. G. Britain; Academic Press, New York. .Vol. 278 (2001) 33-65.
14. F. Belal, A. M. Galal, A. A. Al-Majed and F. S. Al-Feraly, “Voltammetric study of parthenolide and its determination in biological fluids.” Photochemical Analysis, 12 (2001) 250-254.
15. A. A. Al-Majed and J. Al-Zehouri, “Use of 7-Fluoro-4-nitrobenzo-2-1,3-diazole (NBD-F) for Determination of Ramipril in Tablets and Spiked Human Plasma” Il Farmaco, 56 (2001) 291-296.
16. A. A. Al-Majed, F. Belal and A. A. Al-Warthan, “Spectrophotometric Determination of ramipril (A novel ACE inhibitor) in dosage forms.” Spectroscopy Letters, 34 (2001) 211-220.
17. Sami G. Abdel Hamid, Humeida A. El-Obeid, Abdulrahman A. Al-Majed, Hassan A. El-Kashef and Hussein I. Al-Sabbagh, “Synthesis and Anticonvulsant Activity of Some New 4-Oxo-3H-quinazoline Analogs.” Medicinal Chemistry Research, 10 (2001) 378-389.
18. F. Belal, H. Abdine, A. A. Al-Majed and N. Y. Khalil, “Spectrofluorometric determination of vigabatrin and gabapentin in urine and dosage forms through derivatization with fluorescamine.” Journal of Pharmaceutical and Biomedical Analysis, 27 (2002) 253-260.
19. F. Belal, A. Al-Majed, K.E.E. Ibrahim and N.Y.Khalil, “Voltammetric Determination of Josamycin (A macrolide Antibiotic) in Dosage Forms and spiked Human Urine.” Journal of Pharmaceutical and Biomedical Analysis, 30, 705-713 (2002).
20. Abdulrahman A. Al-Majed, Fathalla Belal, Mohammed A. Abounassif and Naser Y. Khalil, “Fluorometric Determination of Gentamicin in Dosage Forms and Biological Fluids Through Derivatization with 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl).” Microchimica Acta, 141, 1-6 (2003).
21. Abdulrahman A. Al-Majed, Fathalla Belal, Kamal E. E. Ibrahim and Nasr Y. Khalil, “Kinetic Spectrophotometric Determination of the Macrolide Antibiotic Josamycin in Formulations,” Journal of AOAC International, 86, (2003).
22. F. Belal, A. Al-Majed and S. Julkhuf, “Voltammetric determination of isradipine in dosage forms and spiked human plasma and urine.” Journal of Pharmaceutical and Biomedical Analysis, 31, 989-998 (2003).
23. M. Al-Omar, A. Al-Majed, M. Sultan, E A. Gadkariem, F. Belal, “Voltammetric Study of Danazole and its Determination in Capsules and spiked Biological Fluids.” Journal of Pharmaceutical and Biomedical Analysis, 37, 199-204 (2003).
24. F. Belal, A. A. Al-Majed, S. Julkuf and Nasr Y. Khalil, “Spectrofluorometric Determination of Nimodepine in Dosage Forms and Spiked Human Urine.” Pharmazie, 58, 874-876 (2003)
25. Fathalla Belal, A.A. Al-Majed, K.E.E. Ibrahim and N.Y.Khalil, “Anodic Polarographic Determination of Josamycin in Formulations and spiked Human Urine.” Il Farmaco, 59, 537-542 (2004).
26. F. Belal, A. A. Al-Majed and S. Julkhuf, “Anodic Polarographic Determination of Isradipine in Pharmaceutical Formulations.” Scientia Pharmaceutica, 27, 131-142 (2004).
27. Abdulrahman Al-Majed, Fathallah Belal, Saeed Julkhuf and Hussein El-Subbagh, Penicillamine: Physical Profile. Profiles of Drug Substances, Excipients and Related Methodology, Volume 32, 2005, Pages 119-130.
28. Abdulrahman Al-Majed, Fathallah Belal and Saeed Julkhuf, Penicillamine: Analytical Profile Profiles of Drug Substances, Excipients and Related Methodology, Volume 32, 2005, Pages 131-148.
29. Abdulrahman Al-Majed, Fathallah Belal and Saeed Julkhuf, Penicillamine: Adsorption, Distribution, Metabolism, and Elimination Profile Profiles of Drug Substances, Excipients and Related Methodology, Volume 32, 2005, Pages 149-152.
30. Abdulrahman A. Al-Majed, "A derivative Reagent for Vigabatrin and Gabapentin in HPLC with fluorescence Detection." Journal of Liquid Chromatography & Related Technologies, 28, 3119-3129 (2005).
31. A. Al-Majed, F. Belal, N. Y. Khalil and K. E. E. Ibrahim, "A stability-Indicating HPLC Method for the Determination of Methicillin in Vials and Biological Fluids with Fluorescence Detection." Journal of Liquid Chromatography & Related Technologies, 28, 1737-1750 (2005).
32. Ibrahim A. Darwish, Ashraf M. Mahmoud, Abdel-rahman A. Al Majed “Generic Simple Enzyme Immunoassay Approach to Avert Small Molecule Immobilization Problems on Solid Phases. Application to the Determination of Tobramycin in Serum”, Talanta, 72, 1322-1328 (2007).
33. M. Hefnawy, A. Al Al-Majed, “Natural Phenolic Compounds Separation by Planar Chromatography” Chapter in Encyclopedia of Chromatography, 1:1, 1-20 (2007).
34. Gamal A. E. Mostafa, Mohammed M. Hefnawy, A. Al-Majed. "PVC membrane Sensor for Potentiometric determination of Acebutolo". Sensors, 7, 3272-3286 (2007).
35. Abdulrahman A. Al-Majed. "A new method for the determination of some Aminoglycoside Antibiotics by HPLC using 7-fluoro-4-nitrobenz-2-oxa-1,3-diazole (NBD-F) as a Fluorogenic Precoloumn Label” Chromatographia, 86, 927-931 (2008).
36. Gamal A. E. Mostafa, A. Al-Majed. "Characteristics of new composite-and classical potentiometric sensors for the detrmination of pioglitazone in some pharmaceutical folrmulations". Journal of Pharmaceutical and Biomedical Analysis, 48, 57-61 (2008).

37. Gamal A. E. Mostafa, Mohammed M. Hefnawy, A. Al-Majed. " PVC membrane Sensor for Potentiometric determination of Fluoxetine in Some Pharmaceutical Formulations". Instrumentation science and technology, 36, 279-290 (2008).

38. Ibrahim A. Darwish, Ashraf M. Mahmoud, Tarek Aboul-Fadl, Abdul-Rahman A. Al-Majed " A high sensitive enzyme immunoassay for evaluation of 2-deoxycytidine plasma level as a prognostic marker for breast chemotherapy". Analytica Chimica Acta, 632, 266-271 (2009).

39. Gamal A. E. Mostafa, Mohammed M. Hefnawy, A. Al-Majed. " Separation and Determination of Clenbuterol by HPLC using a vancomycin chiral Stationary Phase", The Journal of AOAC International. 92 (2009) 824–829.

40. Abdulrahman A. Al-Majed "A direct HPLC method for the resolution and quantitation of the R-(-)- and S-(+)- enantiomers of vigabatrin in pharmaceutical products using teicoplanin aglycone chiral stationary phase and UV detection". Journal of Pharmaceutical and Biomedical Analysis. 50 (2009) 96-99.

41. "Liquid chromatographic high-throughput analysis of the new ultra-short acting hypnotic 'HIE-124' and its metabolite in mice serum using a monolithic silica column" Adnan Kadi, Mohamed Hefnawy, Abdulrhman Al-Majed, Sanad Alonezi, Yousif Asiri, Sabry Attia, Ehab Abourashed, Hussein El-Subbagh Analyst, (2011). DOI: 10, 1039/c0an00381f
42. "Membrane Sensors for the Selective Determination of Donepezil Hydrochloride", Gamal Abdel Hafiz Mostafa, Mohamed Hefnawy, and Abdulrahman Al-Majed, J. AOAC Int. 93 (2010) 549–555.
43. " Highly Sensitive HPLC Method with Automated Co-Sense System and Fluorescence Detection for Determination of Sertraline in Human Plasma". Nasr Y. Khalil, Ashraf M. Mahmoud, Ibrahim A. Darwish, Abdul-Rahman A. Al-Majed, Chromatographia 71 (2010) 825-831.
44. "Novel Analytical Approach for Reducing the Consumption of Organic Solvents in the Charge Transfer-Based Spectrophotometric Analysis of Losartan Potassium" , Ibrahim A. Darwish, Ashraf M. Mahmoud, Abdul-Rahman A. Al-Majed, Int. J. Res. Pharm. Sci. 1 (2010) 391-395.

 
Underway Research Projects:
Research Project from King Abdulaziz City for Science and Technology (KACST) entitled: “Adverse Reactions Study of Enantiomers of Some Important Anti-hypertensive Drugs Using Chromatographic Methods.”

Teaching Courses:
Teaching B.Sc. and M.Sc. Degrees Courses

PHC Code Description Credit Hours Teaching Stages
PHC 261 Pharmaceutical Analytical Chemistry 1 5 B.Sc.
PHC 262 Pharmaceutical Analytical Chemistry 2 5 B.Sc.
PHC 461 Instrumental Analysis 3 B.Sc.
PHC 524 Spectrophotometric Method in Drug Analysis 3 M.Sc.
PHC 526 Special Courses in Pharmaceutical Analysis 2 M.Sc.
PHC 527 Pharmacokinetics for Drug Analysis 3 M.Sc.
PHC 591 Pharmaceutical Reference 1 M.Sc.
PHC 592 Seminar 1 M.Sc.

Supervision on Master Degree Theses for the following:

1. Mr. Riyadh Al-Shaba’an, Master Degree Student, thesis entitled: “Degradation kinetics and stability indicating studies for nicardipine hydrochloride.” Discussion was held in the Second Semester 1999 2000.
2. Mr. Hamoud Al-Malaq, Master Degree Student, thesis entitled: "Analytical Study of Some Phenolic compounds of Pharmaceutical Interest." Discussion was held in the First Semester 2000 2001.
3. Ms. Mona Alshari, Master Degree Student, thesis entitled: "Metabolic study on ,N-Disubstituted Phenylethylamine derivatives." Discussion was held in the Second Semester 2000 2001.
4. Mr. Saeed Al-Qhatani, Master Degree Student, thesis entitled: "A contribution to the Analysis of Some 1,4-Dihydropyridine Calcium Channel Blockers." Discussion was held in the First Semester 2000 2001.
5. Mr. Mohammed Al-Thanian, thesis entitled: "Use of fluorogenic reagents for the analysis of some ACE inhibitors.” Discussion was held in the First Semester 2004 2005.
6. Mr. Sanad Mohammed Alonezi, thesis entitled “ High-Throughput analysis for certain Drugs Using Monolithic Silica HPLC Column”. Discussion was held in the First Semester 2009 2010.
7. Mr. Mofarreh Mohammed Al-Asmari, thesis entitled “ Comparative Study for Different Stationary Phases in Development of a Stability-indicating Method by HPLC Technique for Determination of Darifenacin” (2011- ).

Supervision on Ph.D Degree Theses for the following:
Mr. Aymen Khalid Al-Suwailem: thesis entitled “ Chiral Chromatographic Analysis of some amino alcohol containing pharmaceuticals” Discussion was held in the Second Semester 2010 2011.

Member of Discussion Committee in the Master Degree Theses for the following:
1. Mr. Ibrahim Al-Zaq, thesis entitled: “A contribution to the analysis of some angiotensin-converting enzyme (ACE) inhibition.” Discussion was held in the College of Pharmacy, King Saud University in the First Semester 2000 2001.
2. Mr. Sa’ad Al-Qarani, thesis entitled: “High performance liquid chromatography of Cannabis Stiva L.” Discussion was held at College of Science, King Saud University in the First Semester 1998 1999.
3. Ms. Maha Al Nowaiser, thesis entitled: “Determination of some organic contents of some dates palm cultivars by chromatographic methods.” Discussion was held at Girls College of Education, Riyadh in 2003 2004.
4. Mr. Abdulrahman M.A. Al Dabbakh, thesis entitled: “Application of electrogenerated chemiluminescence on the determination of some compounds of pharmaceutical use by flow injection analysis.” Discussion was held at College of Science, King Saud University in the Second Semester 2003 2004.
5. Mr. Mohammed M. Al-Barati, thesis entitled: “Determination of some Derivative 1,4-Dihydropyridine Calcium Channel Blockers Using Merging Zone-Flow Injection and Chemiluminescence.” Discussion was held in the Second Semester 2006 2007.

Member of Discussion Committee in the Ph.D. Degree Theses for the following:
Mr. Saeed Al-Qhatani, Ph.D. Degree, thesis entitled: "Analysis of Selected Drugs at Nano Level Using Capillary Electrophoresis and Monolithic Silica High-Performance Liquid Chromarography Methods” " Discussion was held in the First Second 2009-2010.

Participation in Print Media:
- Columns of two pages were contributed in the monthly Magazine Alasra (Family) regarding health for the following subjects:
• Optimal use of medicines
• Aspirin
• Drug and Pregnancy
• Drug and Nursing
• Antibiotics
• Drug Dosage
• Hypertension and the Treatment
• Diabetes and Treatment
• Antipyretic Drugs
• Banned Drugs in Pregnancy
• Peptic an d duodenal ulcer and Treatment
• Asthma and Treatment

- Writing one Chapter of the documentary book to mark the 50th anniversary of the founding of King Saud University concerning College Health Sciences

Refereeing of Research Articles and books:

Refereeing of several research articles from the following Journals:
1- The Journal of Pharmaceutical and Biomedical Analysis
2- The Saudi Pharmaceutical Journal
3- Talanta
4- Journal of the College of Science , King Saud University, Riyadh
5- Spectroscopy Letters

b

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الدرجة العلمية:


السجل الوظيفي:


الاهتمامات البحثية:


الخبرات:


المؤتمرات:


معلومات التواصل:


المقررات الدراسية:

Untitled document

Ghulam Mohammad, MSc, PhD

Associate Professor

Department of Ophthalmology

Faculty of Medicine, King Saud University

Riyadh,Saudi Arabia.

Email Id: mghulam@ksu.edu.sa

Acedmic Qualification:
PhD (2005-2008)    Biochemistry     Banaras Hindu University, Varanasi, India 
Post Doctoral  (2008-2011)     Diabetic retinopathy Wayne state University, Detroit, MI, USA   

Honors/Awards
•         Research Fellowship and pre-doctoral grant from Council of Scientific and Industrial Research - National Eligibility Test (CSIR-NET) (2005-2008).
•         Graduate Aptitude Test in Engineering (GATE) – For Life Sciences (2005-National level, Percentile score: 96.89

 Ongoing funded Projects:

 Ø  Role of circulating bone marrow -derived stem cells in retinal angiogenesis.

Ø 

Role of MMP-9 in retinal angiogenesis and the early stages of vacular inflammation in diabetic animals.

Ø 

Interaction between activated retinal endothelial cells and fibroblasts in the development of fibrovascular proliferating in diabetic retinopathy.

Grant details: Submitted (March 2012 and September 2012 competition) for funding in National Plan for     Science, Technology and Innovation; King Dom of Saudi Arabia. (12 MED 2604-02)

 Title:

Ø 

The role of High-mobility group box 1 protein in the development of Diabetic retinopathy 

Ø 

The role of Matrix metalloproteinase-2 and 9 in the development of diabetic retinopathy

PUBLICATIONS IN PEER REVIEWED JOURNALS

List of Publications:

1. Association of High-mobility Group Box-1 with Oxidative Stress Markers and Regulators in Proliferative Diabetic Retinopathy. Abu El-Asrar AM, Alam K, Marta G R, Ahmad A, Siddiquei MM, Mohammad G, Mousa A, De Hertogh G, Opdenakker G, and Simó R. Mol Vis., accepted 18July 2017.
2. Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative DiabeticRetinopathy. Abu El-Asrar AM, Struyf S, Mohammad G, Gouwy M, Rytinx P, Siddiquei MM, Hernández C, Alam K, Mousa A, De Hertogh G, Opdenakker G, Simó R. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3189-3201. doi: 10.1167/iovs.16-20993.[ PMID: 28654984].
3. Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy. Abu El-Asrar AM, Ahmad A, Bittoun E, Siddiquei MM, Mohammad G, Mousa A, De Hertogh G, Opdenakker G.  Acta Ophthalmol. 2017 Apr 9. doi: 10.1111/aos.13451. [Epub ahead of print] PMID: 28391660.
4. Extracellular 9 matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy. Abu El-Asrar AM, Ahmed A, Alam K, Siddiquei MM, Mohammad G, Hertogh G,  Mousa A,  Opdenakker G. Acta Ophthalmol. 2016 Sept 13, doi: 10.1111/aos.13284 (PMID: 27860331).
5. Myeloid-related protein-14/MRP-14/S100A9/calgranulin B is associated with inflammation in proliferative diabetic retinopathy. Abu El-Asrar AM,  Alam K, Siddiquei MM, Mohammad G, Hertogh G,  Mousa A,  Opdenakker G. Ocular Immunology and Inflammation. 2016 October 4 (PMID: 27849448).
6. High-Mobility Group Box-1 Protein Mediates the Regulation of Signal Transducer and Activator of Transcription-3 in the Diabetic Retina and in Human Retinal Müller Cells. Mohammad G, Jomar D, Siddiquei MM, Alam K, Abu El-Asrar AM. Ophthalmic Res. 2016 Aug 25(PMID: 27560926).
7. High-mobility group box-1 regulates the expression of matrix metalloproteinase-9 in diabetic retina Mohammad G, Siddiquei MM , Nawaz MI,  Alam K, Mousa A, Abu El-Asrar AM. Journal: Int J Clin Exp Pathol.2016 January, 9 (2), 828-840.
8. Upregulation of Thrombin/Matrix Metalloproteinase-1/Protease-Activated Receptor-1 Chain in Proliferative Diabetic Retinopathy. Abu El-Asrar AM, Alam K, Nawaz MI, Mohammad G, Van den Eynde K, Siddiquei MM, Mousa A, Hertogh G, Opdenakker G. Curr Eye Res. 2016 Jun 3:1-11(PMID: 27261371).
9. Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy. Abu El-Asrar AM, Siddiquei MM, Nawaz MI, De Hertogh G, Mohammad G, Alam K, Mousa A, Opdenakker G. Mol Vis. 2016 Apr 30;22:424-35. eCollection 2016 (PMID: 27168718).
10. Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes. Abu El-Asrar AM, Alam K, Nawaz MI, Mohammad G, Van den Eynde K, Siddiquei MM, Mousa A, De Hertogh G, Geboes K, Opdenakker G. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8239-47 (PMID: 26720478).
11. Mutual Enhancement Between High-Mobility Group Box-1 And NADPH Oxidase-Derived Reactive Oxygen Species Mediates Diabetes-Induced Upregulation Of Retinal Apoptotic Markers. Mohammad G*, Alam K, Nawaz MI, Siddiquei MM, Abu El-Asrar AM. J Physiol Biochem. 2015 Sep;71(3):359-72. PMID: 26040511.
12. Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes. Abu El-Asrar AM, Alam K, Nawaz MI, Mohammad G, Van den Eynde K, Siddiquei MM, Mousa A, De Hertogh G, Geboes K, Opdenakker G. Invest Ophthalmol Vis Sci. 2015 Dec 1;56(13):8239-47. 
13. Tiam1-Rac1 axis promotes activation of p38 MAP kinase in the development of diabetic retinopathy: Evidence for a requisite role for protein palmitoylation. Veluthakal R,  Kumar B, Mohammad G, Kowluru RA, Kowluru A. Cell Physiol Biochem 2015;36(1):208-20. doi: 10.1159/000374065. Epub 2015 Apr 30. (3.55 Impact Factor). PMID: 25967961
14. The Chemokine Platelet factor-4 variant (PF-4var)/CXCL4L1 Inhibits Diabetes-induced Blood-retinal Barrier Breakdown. Abu El-Asrar AM, Mohammad G, Nawaz MI, Abdelsaid M, Siddiquei MM, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S. Invest Ophthalmol Vis Sci. 2015 Feb 24. pii: IOVS-14-16144. doi: 10.1167/iovs.14-16144. (3.6 Impact Factor). PMID: 25711636.
15. The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor inducible protein 14 are upregulated in proliferativediabetic retinopathy. Abu El-Asrar AM, Nawaz MI, De Hertogh G, Al-Kharashi AS, Van den Eynde K, Mohammad G, Geboes K. Ophthalmic Res. 2015;53(3):122-30. (1.6 Impact Factor)   PMID: 25676319
16. Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. Abu El-Asrar AM, Nawaz MI, Mohammad G, Siddiquei MM, Alam K, Opdenakker G. Lipids Health Dis. 2014 Dec 11;13(1):187. (2.6 Impact Factor) PMID: 25496321
17. Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte–endothelial interactions. Nawaz MI and Mohammad G*. J Recept Signal Transduct Res. 2015 Aug;35(4):340-5. (2.6 Impact Factor) PMID: 26482025.
18. High-mobility group box-1 modulates the expression of inflammatory and angiogenic signaling pathways in diabetic retina Abu El-Asrar AM, Mohammad G, Nawaz MI, Siddiquei MM. Curr Eye Res. 2014 Dec 11:1-12. (1.76 Impact Factor). PMID: 25495026.
19. S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis. Abu El-Asrar AM, Nawaz MI, De Hertogh G, Al-Kharashi AS, Van den Eynde K, Mohammad G, Geboes K, Opdenakker G. Molecular Vision 2014; 20:1209-1224. (2.9 Impact Factor). PMID: 25253987.
20. Functional links between gelatinase B/matrix metalloproteinase-9 and prominin-1/CD133 in diabeticretinal vasculopathy and neuropathy. Mohammad G, Vandooren J, Siddiquei MM, Martens E, Abu El-Asrar AM, Opdenakker G. Prog Retin Eye Res. 2014 Jul 28. pii: S1350-9462(14)00042-1. doi: 10.1016/j.preteyeres.2014.07.002. [Epub ahead of print] PMID: 25080402. (11.2 Impact Factor).
21. The Angiogenic Biomarker Endocan is Upregulated in Proliferative  Diabetic  Retinopathy and Correlates with Vascular Endothelial Growth Factor. Abu El-Asrar AM, Nawaz MI, De Hertogh G, Al-Kharashi AS, Van den Eynde K, Mohammad G, Geboes K. Curr Eye Res. 2014 May 28:1-11. PMID: 24871583. (1.76 Impact Factor).
22. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos JM, Mishra M. Diabetologia. 2014 May;57(5):1047-56. doi: 10.1007/s00125-014-3194-z. PMID: 24554007. (7.06 Impact Factor)
23. The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes. Abu El-Asrar AM, Siddiquei MM, Nawaz MI, Geboes K, Mohammad G. Mediators Inflamm. 2014;2014:746415. doi: 10.1155/2014/746415. Epub 2014 Mar 10.PMID: 24733965. (3.88 Impact Factor)
24. Cellular mechanisms of high mobility group 1 (HMGB-1) protein action in the diabetic retinopathy. Santos AR, Dvoriantchikova G, Li Y, Mohammad G, Abu El-Asrar AM, Wen R, Ivanov D. PLoS One. 2014 Jan 31;9(1):e87574. doi: 10.1371/journal.pone.0087574.PMID: 24498140. (4.06 Impact Factor)
25. Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy.Abu El-Asrar AM, Mohammad G, De Hertogh G, Nawaz MI, Van Den Eynde K, Siddiquei MM, Struyf S, Opdenakker G, Geboes K. PLoS One. 2013 Jun 7;8(6):e65472. doi: 10.1371/journal.pone.0065472. Print 2013.PMID:23762379.(4.06 Impact Factor)
26. Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabeticretinopathy.Abu El-Asrar AM, Mohammad G, Nawaz MI, Siddiquei MM, Kangave D, Opdenakker G. Acta Diabetol. 2013 Jun;50(3):363-71. doi: 0.1007/s00592-012-0422-1. .PMID: 22864860. (4.25 Impact Factor)
27. Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced indiabetic retinopathy.Nawaz MI, Van Raemdonck K, Mohammad G, Kangave D, Van Damme J, Abu El-Asrar AM, Struyf S. Exp Eye Res. 2013 Apr;109:67-76. doi: 10.1016/j.exer.2013.01.008.PMID:23352833. (3.06 Impact Factor)
28. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Mohammad G*, Siddiquei MM, Othman A, Al-Shabrawey M, Abu El-Asrar AM. Exp Eye Res. 2013 Feb;107:101-9. doi: 10.1016/j.exer.2012.12.009. PMID: 23261684. (3.06 Impact Factor)
29. New developments in the pathophysiology and management of diabetic retinopathy. Abu El-Asrar AM, Midena E, Al-Shabrawey M, Mohammad G*. J Diabetes Res. 2013;2013:424258. doi: 10.1155/2013/424258.PMID: 24392456.(3.56 Impact Factor)
30. The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina. Mohammad G*, Mairaj Siddiquei M, Imtiaz Nawaz M, Abu El-Asrar AM. J Diabetes Res. 2013;2013:658548. doi: 10.1155/2013/658548. PMID:23671886 (3.56 Impact Factor)
31. Poly (ADP-ribose) polymerase mediates diabetes-induced retinal neuropathy. Mohammad G*, Siddiquei MM, Abu El-Asrar AM. Mediators Inflamm. 2013;2013:510451. doi: 10.1155/2013/510451. PMID: 24347828. (3.88 Impact Factor)
32. High-mobility group box-1 induces decreased brain-derived neurotrophic factor-mediated neuroprotection in the diabetic retina. Abu El-Asrar AM, Nawaz MI, Siddiquei MM, Al-Kharashi AS, Kangave D, Mohammad G. Mediators Inflamm. 2013;2013:863036. doi: 10.1155/2013/863036. PMID: 23766563 (3.88 Impact Factor)
33. Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy. Abu El-Asrar AM, Mohammad G, Nawaz MI, Siddiquei MM, Van den Eynde K, Mousa A, De Hertogh G, Opdenakker G. PLoS One. 2013 Dec 31;8(12):e85857. doi: 10.1371/journal.pone.0085857. eCollection 2013.PMID: 24392031. (4.06 Impact Factor)
34. Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy. Mohammad G*, Siddiquei MM. J Ocul Biol Dis Infor. 2012 Jul 6;5(1):1-8. doi: 10.1007/s12177-012-9091-0. PMID: 23833698. (0.6 Impact Factor)
35. Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9. Mohammad G, Kowluru RA. J Cell Physiol. 2012 Mar;227(3):1052-61. doi: 10.1002/jcp.22822. PMID: 21567393. (4.22 Impact Factor) 
36. High-mobility group box-1 and endothelial cell angiogenic markers in the vitreous from patients with proliferative diabetic retinopathy. Abu El-Asrar AM, Nawaz MI, Kangave D, Abouammoh M, Mohammad G. Mediators Inflamm. 2012;2012:697489. doi: 10.1155/2012/697489. PMID: 23118492. (3.88 Impact Factor)
37. Abrogation of MMP-9 gene protects against the development of retinopathy in  diabetic mice by preventing mitochondrial damage. Kowluru RA, Mohammad G, dos Santos JM, Zhong Q. Diabetes. 2011 Nov;60(11):3023-33. doi: 10.2337/db11-0816. PMID: 21933988 ((8.16 Impact Factor)
38. Novel role of mitochondrial matrix metalloproteinase-2 in the development of  diabetic retinopathy. Mohammad G, Kowluru RA. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3832-41. doi: 10.1167/iovs.10-6368. PMID: 21345984. (3.66 Impact Factor)
39. Interleukin-1β and mitochondria damage, and the development of diabetic  retinopathy. Kowluru RA, Mohammad G, Santos JM, Tewari S, Zhong Q.J Ocul Biol Dis Infor. 2011 Jun;4(1-2):3-9. doi: 10.1007/s12177-011-9074-6. PMID: 23272269 (0.6 Impact Factor)
40. The role of Raf-1 kinase in diabetic retinopathy. Mohammad G, Kowluru RA. Expert Opin Ther Targets. 2011 Apr;15(4):357-64. doi: 0.1517/14728222.2011.553604. PMID: 21254925. (5.3 Impact Factor)
41. Diabetic retinopathy, superoxide damage and antioxidants. Santos JM, Mohammad G, Zhong Q, Kowluru RA. Curr Pharm Biotechnol. 2011 Mar 1;12(3):352-61. PMID: 20939803. (3.45 Impact Factor)
42. Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression. Madsen-Bouterse SA, Mohammad G, Kanwar M, Kowluru RA. Antioxid Redox Signal. 2010 Sep 15;13(6):797-805. doi: 10.1089/ars.2009.2932. PMID: 20088705(8.56 Impact Factor)
43. Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction. Mohammad G, Kowluru RA. Lab Invest. 2010 Sep;90(9):1365-72. doi: 10.1038/labinvest.2010.89. PMID: 20479714 (4.06 Impact Factor)
44. Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Madsen-Bouterse SA, Zhong Q, Mohammad G, Ho YS, Kowluru RA. Free Radic Res. 2010 Mar;44(3):313-21. doi: 10.3109/10715760903494168. PMID: 20088710. (3.38 Impact Factor)
45. Glyceraldehyde-3-phosphate dehydrogenase in retinal microvasculature: implications for the development and progression of diabetic retinopathy. Madsen-Bouterse S, Mohammad G, Kowluru RA. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1765-72. doi: 10.1167/iovs.09-4171. Epub 2009 Oct 29. PMID: 19875652 (3.5 Impact Factor)
46. Angiogenesis in Granulation Tissue of Type 2 Diabetes Mellitus Patients Wound. Mohammad G*,Vaibhav V, Pandey H P, Tripathi K, Msalati A A. Asian J. Exp. Sci., 2009; 23, 567-573.
47. Antioxidant properties of some Nanoparticle may Enhance Wound Healing in T2DM Patients. Mohammad G*, Mishra V K, Pandey H P. Digest Journal of Nanomaterials and Biostructures 2008; 3:159-162. (1.73 Impact Factor)
48. Diabetic wound healing and it’s angiogenesis with special Reference to nanoparticles. Mohammad G*, Pandey H P, Tripathi K. Digest Journal of Nanomaterials and Biostructures.2008; 3:203-208. (1.73 Impact Factor)
49. Immunomodulation and anticancer potentials of Yogurt probiotic. Mishra V K, Mohammad G, Jha A. Experimental and Clinical Sciemces, 2008; 7:177-184. (2.00 Impact Factor)
50. Down regulation of telomerase activity may enhanced by Nanoparticle mediated curcumin delivery. Mishra V K, Mohammad G, Mishra S K. Digest Journal of Nanomaterials and Biostructures, 2008; 3:163-169. (1.73 Impact Factor).

Abstracts / Presentations

• Ghulam Mohammad,Varun Kesharvani, H.P.Pandey 2007, Role of free radicals in mitochondrial mediated apoptosis in diabetic wound of human.    33^rd Indian Immunology Society Conference, New Delhi, India (Oral and poster presentation)
• Ghulam Mohammad and Renu A Kowluru 2009. Diabetic Retinopathy and MMP-2: Mitochondrial dysfunction and retinal capillary cell apoptosis. Post doc poster competition, Wayne State University, Detroit. USA 

• Ghulam Mohammad, Renu A Kowluru 2010. Mitochondrial Dysfunction and Diabetic Retinopathy: Role of Matrix Metalloproteinase-2. Poster Presentation May 2-6, 2010, ARVO, Fort Lauderdale, Florida.

• Ghulam Mohammad, Renu A Kowluru Inhibition of MMP9 Protects the Development of Retinopathy in Diabetic Mice Via Ameliorating Mitochondria Dysfunction. Poster Presentation May 1-5, 2011, ARVO, Fort Lauderdale, Florida. USA 

• Ghulam Mohammad, 2013 Matrix metalloproteinase-9 regulates angiogenic and vasculogenic factors in diabetic retina. Poster Presentation May 08, 2013, ARVO, Seattle, USA Investigative Ophthalmology & Visual Science 54 (15), 4600-4600

• A Novel Role of High Mobility Group Box-1 in The Pathogenesis Of Diabetic Retinopathy. Ahmed Abu El-Asrar, Ghulam Mohammad, Mohammad Mairaj Siddiquei, Amira Othman, Georagia and Mohamed Al-Shabrawey. 20 - February 27th-28th and March 1st 2014, 12th International Ocular Inflammation Society Congress, Valencia (Spain) 19.

• Matrix Metalloproteinase-9 Destroys Prominin-1/Cd133 In Diabetes-Induced Retinal Vasculopathy And Neuropathy. Oral Presentation, Ghulam Mohammad, Saudi Ophthalmology 2014 – Abstract Number: 610, Saudi Arab

• High-mobility group box-1 modulates the expression of inflammatory and angiogenic signaling pathways in diabetic retina.Ghulam Mohammad. Poster Presentation May 08, 2014, ARVO, Orlando, USA. Investigative Ophthalmology & Visual Science 55 (13), 1036-1036.

• Platelet factor-4 variant (CXCL4L1/PF-4var) antagonizes VEGF functions and inhibits diabetes-induced blood-retinal barrier breakdown. Poster Presentation Feb 28, 2015, Association for Ocular Pharmacology and Therapeutics, Charleston, USA.

• Mutual Enhancement Between High-Mobility Group Box-1 And NADPH Oxidase-Derived Reactive Oxygen Species Mediates Diabetes-Induced Upregulation Of Retinal Apoptotic Markers. Ghulam Mohammad. European Association for Vision and Eye Research (EVER) Congress. Nice, France (7-10 Oct. 2015). Invited Speaker.

Book Chapter

 
Ghulam Mohammad (2016). High-Mobility Group Box-1 Protein a Potential Inflammatory Biomarker in Diabetic Retinopathy, Role of Biomarkers in Medicine, Prof. Mu Wang (Ed.), InTech, DOI: 10.5772/62524. Available from: http://www.intechopen.com/books/role-of-biomarkers-in-medicine/high-mobility-group-box-1-protein-a-potential-inflammatory-biomarker-in-diabetic-retinopathy