Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride
Two metal oxide nanoparticles, magnesium oxide nanoparticles (MgONPs) and aluminum oxide nanoparticles (Al2O3NPs), were synthesized from green sources, Salvia officials
and Cuminum cyminum seed extract, respectively. These nanoparticles were used for construction of potentiometric enhancement sensors employed for the estimation of ranitidine hydrochloride (RNT) in authentic powder and commercial products. The electroactive substance ranitidinephosphotungstate (RNT-PT) was formed by combining RNT with phosphotungstic acid (PTA) in
the presence of plasticizing material o-nitrophenyloctyl ether (o-NPOE). The outcomes showed
that the enhanced MgO and Al2O3 nanosensors behaved linearly across the concentration ranges
1.0 × 10−9–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1
, respectively. However, the conventional
sensor (RNT-PT) displayed a linearity over 1.0 × 10−6–1.0 × 10−2 mol L−1
. Least square equations
were calculated as EmV = (54.1 ± 0.5) log (RNT) + 762.33, EmV = (58.6 ± 0.2) log (RNT) + 696.48, and
EmV = (52.2 ± 0.7) log (RNT) + 756.76 for enriched nanometal oxides modified and conventional
sensors, respectively. The correlation coefficients of regression equations were 0.9997, 0.9995, and
0.9992 for the above suggested sensors, respectively. The recorded results showed excellent sensitivity
and selectivity of the modified nanometal oxide sensors for the quantification of the analyzed drug in
its authentic samples and commercial products.
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