Gut microbiome and mitochondrial crosstalk in Schizophrenia, a mental disability: Emerging mechanisms and therapeutic targets
Gut-mitochondria is an emerging paradigm in understanding the pathophysiology of complex neuropsychiatric disorders such as Schizophrenia (SCZ). This bidirectional communication network connects the gastrointestinal microbiota with mitochondrial function and brain health, offering novel insights into disease onset and progression. SCZ, characterized by hallucinations, delusions, cognitive impairments, and social withdrawal, has traditionally been attributed to genetic and neurochemical imbalances. However, growing evidence highlights the role of systemic factors specifically, gut microbiome dysbiosis and mitochondrial dysfunction as key contributors to its etiology. Gut dysbiosis in SCZ involves a decrease in health-promoting microbiota such as Faecalibacterium and Roseburia, as well as an increase in pro-inflammatory taxa such
Long noncoding RNAs (LncRNAs)/circular RNAs are important noncoding RNAs in plants that play important roles in different metabolic and development functions.
Gut-mitochondria is an emerging paradigm in understanding the pathophysiology of complex neuropsychiatric disorders such as Schizophrenia (SCZ). This bidirectional communication network connects…
Hypertension is a complex, age-related condition that markedly elevates the risk of cardiovascular problems and mortality globally. With the aging global population, understanding the molecular…