Aging-related epigenetic instability in lncRNAs and miRNAs mediates the development of
European Journal of Pharmacology
Hypertension is a complex, age-related condition that markedly elevates the risk of cardiovascular problems and mortality globally. With the aging global population, understanding the molecular foundations of hypertension is essential. Emerging evidence highlights the essential roles of non-coding RNAs, particularly Long non-coding RNAs and microRNAs, in regulating gene expression linked to vascular health and blood pressure control. This review examines the impact of aging on the expression and synthesis of key ncRNAs, which leads to malfunction in three pivotal systems: vascular smooth muscle cells, the renin-angiotensin-aldosterone system, and endothelial cells. Dysregulated ncRNAs impair nitric oxide bioavailability, enhance inflammation, and modify vascular tone, resulting in arterial stiffness and increased blood pressure.
Long noncoding RNAs (LncRNAs)/circular RNAs are important noncoding RNAs in plants that play important roles in different metabolic and development functions.
Gut-mitochondria is an emerging paradigm in understanding the pathophysiology of complex neuropsychiatric disorders such as Schizophrenia (SCZ). This bidirectional communication network connects…
Hypertension is a complex, age-related condition that markedly elevates the risk of cardiovascular problems and mortality globally. With the aging global population, understanding the molecular…