Dietary Protective Influence of Petroselinum crispum Nanoparticles on Some Biochemical, Reproductive Hormones, and Physiological Biomarkers of Female Clarias gariepinus (Burchell,1822) Exposed to Bisphenol A Toxicity
African catfish; biochemical parameters; bisphenol A; Petroselinum crispum nanoparticles; reproductivehormones
The currentstudyisapioneertrialtoverifytheeffectivenessof Petroselinum crispum (parsley) nanoparticles(PNPs)forfortifying
physiological andbiochemicalbiomarkersinfemaleAfricancatfish postexposuretobisphenolA(BPA)toxicity.Theaimofthis
experiment istoverifytheinfluence ofPNPsformitigatingserumhemato-biochemicalalterationsaswellasantioxidantenzyme,
and hormonalchangesinducedbyBPAtoxicityinthehepaticandovariantissues.Fishwereequallyallocatedintofourgroups:
group Iasacontrolwithoutanytreatments,groupIIreceivedacommercialdiet +PNPs (4g/kgdiet).IngroupIII, fish were
subjected to1/10LC50(BPA)(1.43 μg/L), whileingroupIV, fish got1/10LC50BPA(1.43 μg/L)+PNPs (4g/kgdiet)for60
consecutive days.ExposuretoBPAshowedmacrocytichypochromicanemiaandleukopenia,andanoticeableelevationinglucose,
alanine amino-transferase(ALT),aspartateaminotransferase(AST),ALP,urea,creatinine,cortisol,cholesterol,andtestosterone
(T) hormone.Furthermore,serumAchE,estradiol(E2),follicle-stimulatinghormone(FSH),luteinizinghormone(LH),globulin,
albumin, andtotalproteinsweresignificantly decreasedinaBPA-exposedgroup.Alternatively,activitiesofsuperoxidedismutase
(SOD), lipidperoxidation(LPO),andcatalase(CAT)werenotablyaugmentedinthehepatictissueandovariesoftheBPA-
supplemented fish. Whiletotalantioxidantcapacity(TAC)andreducedglutathione(GSH)levelsdecreasedintheequaltissuesof
exposed fish. PNPs-supplementeddietsincombinationwithBPAalleviateditsdestructiveeffectsonthetestedparameters.In
conclusion, theresultsprovedthatBPAisanendocrinehormonaldisruptorthatinducesimbalancesinbloodprofile, hepato–renal
indicators, andstressparameters,besidestheoccurrenceofoxidativedamageandreproductivedysfunction.Interestingly,PNPs
have aprotectiveroleinattenuatingBPAtoxicityandmodulatingallthemeasuredbiomarkers,aswellasimprovingthefertilityof
female Clarias gariepinus.
The currentstudyisapioneertrialtoverifytheeffectivenessof Petroselinum crispum (parsley) nanoparticles(PNPs)forfortifying
physiological andbiochemicalbiomarkersinfemaleAfricancatfish…
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