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عبدالعاطى عبدالعزيز شحات حسين

Professor

استاذ

كلية الصيدلة
34 أب
publication
Journal Article
2024

The antiproliferative effects of Marrubium vulgare, and toxicity screening in zebrafish embryos.

The antiproliferative effects of Marrubium vulgare, and toxicity screening in zebrafish embryos.

Consider the medicinal usefulness and ethnomedicinal uses referring to Marrubium vulgare; the CH3OH extract of whole plant was investigated for the antiproliferative, effect and toxicological screening. Its antiproliferative effect was evaluated against A549 (lung), HepG2 (Liver), MDA-MB-231 (breast) and MCF-7 cancer cell-lines. Doxorubicin was used as a positive control. Toxicological evaluation of the Marrubium vulgare methanol extract (MVM) was carried out in zebrafish embryos. The MVM showed more effective inhibition against MCF-7and MDA-MB-231 breast-cancer cells. The IC50 value ranged from 43.5 to 223.5 μg/mL. In term of IC50 MVM showed a strong antiproliferative effect averse to MDA-MB-231 and MCF-7 in terms of IC50 values (43.5 and 46.5 μg/mL respectively). Lethal concentration of MVM in zebrafish embryos remained 5 µg/ml. The results obtained from zebrafish embryos tests indicates 

Publication Work Type
نشر علمى
Volume Number
36
Magazine \ Newspaper
Journal of King Saud University - Science
Sponsoring Organization
King Saud University
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