The antiproliferative effects of Marrubium vulgare, and toxicity screening in zebrafish embryos.
The antiproliferative effects of Marrubium vulgare, and toxicity screening in zebrafish embryos.
Consider the medicinal usefulness and ethnomedicinal uses referring to Marrubium vulgare; the CH3OH extract of whole plant was investigated for the antiproliferative, effect and toxicological screening. Its antiproliferative effect was evaluated against A549 (lung), HepG2 (Liver), MDA-MB-231 (breast) and MCF-7 cancer cell-lines. Doxorubicin was used as a positive control. Toxicological evaluation of the Marrubium vulgare methanol extract (MVM) was carried out in zebrafish embryos. The MVM showed more effective inhibition against MCF-7and MDA-MB-231 breast-cancer cells. The IC50 value ranged from 43.5 to 223.5 μg/mL. In term of IC50 MVM showed a strong antiproliferative effect averse to MDA-MB-231 and MCF-7 in terms of IC50 values (43.5 and 46.5 μg/mL respectively). Lethal concentration of MVM in zebrafish embryos remained 5 µg/ml. The results obtained from zebrafish embryos tests indicates
Anethum graveolens is an aromatic plant traditionally used as an antispasmodic and carminative. The objective of this study is to analyze the chemical composition of the essential oils and…
There is a high interest in utilizing natural bioactive products derived from plants as a substitute for synthetic chemicals in the industry. This research focuses on the phytochemical composition…
Consider the medicinal usefulness and ethnomedicinal uses referring to Marrubium vulgare; the CH3OH extract of whole plant was investigated for the antiproliferative, effect and…