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صباح أحمد محمد الزهراني

Demonstrator

معيد

كلية العلوم
Address: Building 5, Floor 3, Office no. 5T251
publication
Journal Article
2023

Anticancer and Antimicrobial Activity of Silver Nanoparticles Synthesized from Pods of Acacia nilotica

Anticancer and Antimicrobial Activity of Silver Nanoparticles Synthesized from Pods of Acacia nilotica

Abstract: Green synthesized silver nanoparticles (AgNPs) have been used against antibiotic-resistant bacteria and chemo-resistant cancer cells. We synthesized AgNPs from Acacia nilotica pods, evaluating their antibacterial activity against eight bacterial strains and anticancer efficiency against two colon cancer cell lines, SW620 and SW480. Expression levels of eight genes (β-catenin, APC,TP53, Beclin1, DKK3, Axin, Cyclin D1, and C-myc) were checked by a reverse transcription-polymerase chain reaction in cancer cells before and after treatment with A. nilotica extract and A. nilotica- AgNPs. Prepared nanoparticles were characterized through ultraviolet-visible (UV-vis), Zetasizer, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Fourier transform infrared spectroscopy (FTIR) was used to identify the functional group in extracts. At first, AgNPs were confirmed by a sharp peak of surface plasmon resonance at 375 nm. The Z-average size was 105.4 nm with a polydispersity index of 0.297. TEM showed particle size of 11–30 nm. The prepared AgNPs showed promising antibacterial activity against bacterial strains and cytotoxic activity
against the cancer cell lines. Expression levels of all the genes were affected by extract and
AgNPs treatment. Overall, this study recommended both A. nilotica pods and A. nilotica-AgNPs as attractive candidates for antibacterial and anticancer applications.

Publisher Name
Nuha Sulaiman Alduraihem
Pages
1-17
more of publication
publications

Abstract: Green synthesized silver nanoparticles (AgNPs) have been used against antibiotic-resistant bacteria and chemo-resistant cancer cells. We synthesized AgNPs from Acacia nilotica pods,…

by Nuha Sulaiman Alduraihem 1, Ramesa Shafi Bhat 2,*, Sabah Ahmed Al-Zahrani 2, Doaa M. Elnagar 1, Hussah M. Alobaid 1 and Maha H. Daghestani 1,*
2023
Published in:
Nuha Sulaiman Alduraihem
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by Arwa Althomali , Maha H. Daghestani , Fatimah Basil Almukaynizi , Sabah Ahmed Al-Zahrani , Manal A. Awad , Nada M. Merghani , Wadha I. Bukhari , Eiman M. Ibrahim , Sherifah M. Alzahrani , Nouf Altowair , Afaf S. AL-Ghamdi , Asma M. AlQahtani , Rasha Ramad
2022
Published in:
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Abstract: This study describes a new green method for silver nanoparticles (AgNPs) using Cymbopogon proximus (CP) extract and evaluates their potential anticancer properties

by Hussah M. Alobaid, Maha H. Daghestani, Nawal M. AL-Malahi, Sabah A. Alzahrani, Lina M. Hassen, and Dina M. Metwally*
2022
Published in:
Hussah M. Alobaid