Association of blood groups with hepatitis C viremia
Hepatitis C virus remained a public health problem with approximately half of the patients untreated and
undiagnosed. Chronic HCV is a leading cause of cirrhosis, fibrosis, hepatocellular carcinoma and other
hepatic morbidities. Active HCV has a prevalence rate of about 1% (71 million). By July, 2019, 10 million
population of Pakistan was declared to have active HCV infection. According to World Health
Organization, 23,720 people died of hepatitis-related complexities in Pakistan in 2016. Individuals with
certain types of ABO blood groups were more susceptible to diverse kinds of infections. For instance,
blood types A and AB predisposed individuals to severe malaria, while type O conferred resistance to
the many of the protozoan agent.
This study was designed to explore the association of hepatitis C viremia to blood groups, Rh factors,
age and gender distribution among Pakistani population. Total 246 participants were screened for HCV
in Taqwa diagnostics laboratory, Multan and 200 were found positive. They were divided into 4 groups
on the basis of their age. First group included patients ranging from 17 to 25 (52), second, third and fourth
group included patients from 26 to 34 (92), 35 to 43 (42) and 44 to above (14) respectively. Confirmed
Hepatitis C patients were subjected to analysis of blood group, Rh factor and viral load. Results demonstrated
that patients having ‘O’ blood group (60.37%) were reported for high viral load than any of the
other blood groups in the patients of Southern Punjab, Pakistan. Furthermore, Rh-negative factor
(26.42) was associated with high viral load than that of the Rh-positive factor (73.58). Disclosure practiced
that age group (26–34) was reported for the high viral load than that of the any other group of this
study. Females were more aggressively affected by HCV Viremia than male because the mean viral load
among the females was higher than that of the males. Greater social awareness and gender-sensitive
healthcare is necessary to improve the experiences of patients with HCV. 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access
article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Hepatitis C virus remained a public health problem with approximately half of the patients untreated and
undiagnosed. Chronic HCV is a leading cause of cirrhosis, fibrosis, hepatocellular…
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