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Dr Ali Daoud

Professor

Faculty

كلية العلوم
Department of Zoology College of Science King Saud University, Riyadh, Saudi Arabia

The potential hepatoprotective effect of royal jelly against cadmium chloride-induced hepatotoxicity in mice is mediated by suppression of oxidative stress and upregulation of Nrf2 expression

Moneim, Rafa S.Almeer, SaudAlarifi, SaadAlkahtani, Shaimaa R.Ibrahim, DaoudAli, Abdel . 2018

This study was aimed at investigating the possible protective mechanism of royal jelly (RJ) against hepatotoxicity induced by cadmium chloride (CdCl2). The study included four groups: the control group received saline (0.9% sodium chloride), CdCl2 group received 6.5 mg/kg CdCl2 for seven days, RJ group received 85 mg/kg standardized RJ containing 6% 10-hydroxy-2-decenoic acid equivalent to 250 mg crude RJ, and finally, the fourth group received RJ 2 h before CdCl2 injection daily for 7 days. Oxidant/antioxidant markers of liver function estimation and histopathology were determined. The results revealed that RJ significantly ameliorated the hepatotoxic side effects of Cd. Furthermore, RJ inhibited oxidative stress, inflammation, and hepatic tissue injury; normalized enzymatic and nonenzymatic antioxidant molecules; and enhanced nuclear-related factor-2 (Nrf-2) expression. Our results provide new insights into the hepatoprotective property of RJ and revealed that RJ prevented hepatic injury, oxidative stress, and inflammation by upregulating Nrf2 and the anti-apoptotic protein Bcl-2. Hence, RJ can be used as a hepatoprotective agent against the toxic effects of CdCl2.

Volume Number
106
Magazine \ Newspaper
Biomedicine & Pharmacotherapy
Pages
1490-1498
more of publication
publications

Metal nanomaterials such as bismuth oxide nanoparticles (Bi2O3NPs) have been extensively used in cosmetics, dental materials,pulp capping, and biomedical imaging. There is little knowledge about…

by Ali Alamer1 & Daoud Ali2 & Saud Alarifi2 & Abdullah Alkahtane2 & Mohammed AL-Zharani3 & Mohamed M. Abdel-Daim2,4 & Gadah Albasher2 & Rafa Almeer2 & Nouf K. Al-Sultan2 & Abdulaziz Almalik1,5 & Ali H Alhasan1,5 & Saa
2021
publications

Silver nanoparticles (AgNPs) possess properties that are important for industrial and medical applications. This study is aimed to investigate intra-peritoneal toxicity of AgNPs at 26, 52 or 78 mg…

by Saud Alarifi, Daoud Ali, Mohammed A Al Gurabi & Saad Alkahtani
2017
publications

The present work was designed to investigate the effect of palladium nanoparticles (PdNPs) on human skin malignant melanoma (A375) cells, for example, induction of apoptosis, cytotoxicity, and DNA…

by Saud Alarifi, Daoud Ali, Saad Alkahtani, and Rafa S. Almeer
2017