The impact of poor glycaemic control on the prevalence of erectile dysfunction in men with type 2 diabetes mellitus: a systematic review
Abstract
Objective: To determine the impact of poor glycaemic control on the prevalence of erectile dysfunction among men with type 2 Diabetics aged 27 to 85 years.
Design: The databases Embase classic+Embase, Global health, Ovid Medline and PsychINFO, were searched for relevant studies in June 2014 using the keywords: (Diabetes Mellitus OR diabetes mellitus type2 OR DM2 OR T2DM OR insulin resistance) AND (erectile dysfunction OR sexual dysfunction OR impotence) AND glycaemic control. Setting: All study settings were considered (primary care, secondary care and tertiary care setting).
Participants: Type 2 Diabetic Patients with erectile dysfunction.
Main outcome measures: Included studies must include one of the following outcomes: (1) HBA1c for assess the level of glycaemic control; (2) Erectile dysfunction (any stage: IIEF-5 = 21 or less).
Results: Five cross-sectional studies involving 3299 patients were included. The findings pointed to a positive association between erectile dysfunction and glycaemic control. Three studies showed a significant positive association, while one study showed only a weak correlation and one study showed borderline significance. Patients’ age, diabetes mellitus dur- ation, peripheral neuropathy and body mass index had posi- tive association with erectile dysfunction. However, smoking and hypertension were not associated with erectile dysfunc- tion in most included studies. Physical activity had a protect- ive effect against erectile dysfunction.
Conclusion: We may conclude that the risk of erectile dysfunction is higher in type 2 diabetic men with poor gly- caemic control than those with good control.
Keywords
diabetes, endocrinology, clinical, sexual health
ABSTRACT