Impact of Vitamin D Status Correction on Serum Lipid Profile, Carboxypeptidase N and Nitric Oxide Levels in Saudi Adults

Journal Article

2023

Published in: https://www.mdpi.com/1422-0067/24/9/7711

Abstract: This study aimed to determine the impact on the lipid profile, carboxypeptidase N (CPN)
and nitric oxide (NOx) associated with vitamin D (VD) status correction among Saudi adults with
VD deficiency. A total 111 VD deficient (25(OH)D < 50 nmol/L)) adult Saudis aged 18–50 years
old (57 females and 54 males) were enrolled in this 6-month interventional study. They were given
50,000 IU VD weekly for the first 2 months and then twice a month for the next 2 months, followed by
1000 IU daily for the last 2 months. The fasting lipid profile and the blood glucose, VD, NOx and CPN
concentrations were measured at baseline and after intervention. Post-supplementation, the median
VD was significantly higher (p < 0.001) in females [58.3 (50.6–71.2)] and males [57.8 (51.0–71.8)]. HDL
cholesterol significantly increased (p = 0.05) and NOx significantly decreased (p = 0.02) in males
post-supplementation. Triglycerides were positively associated with NOx in all subjects before
(r = 0.44, p = 0.01) and after (r = 0.37, p = 0.01) VD status correction. There was a significant increase
in serum levels of CPN2 (p = 0.02) in all subjects. Furthermore, CPN was inversely correlated with
NOx (r = −0.35, p = 0.05) in males post-supplementation. In conclusion, VD status correction reduced
serum NOx, particularly in males. The inhibition of NOx synthesis may be responsible for the
anti-inflammatory effects of VD supplementation. An inverse association was found between NOx
and CPN2.

• Publication Work Type: Master