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سالم صالح الرجيعي Salim S. Al-Rejaie


عميد الموارد البشريه بجامعة الملك سعود

كلية الصيدلة
كلية الصيدلة، قسم علم الأدوية والسموم، 2ب95
Journal Article

النشر العلمي

  1. Fatani AJ, Alrojayee FS, Parmar MY, Abuohashish HM, Ahmed MM, Al-Rejaie SS; Myrrh attenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis.; Exp Ther Med. 2016 Aug;12(2):730-738.
  2. AlSharari SD, Al-Rejaie SS, Abuohashish HM, Ahmed MM, Hafez MM.; Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats; Oxid Med Cell Longev. 2016
  3. Fawaz Alasmari, Salim S. Al-Rejaie, Shakir D. AlSharari, Youssef Sari; Targeting glutamate homeostasis for potential treatment of nicotine dependence; Brain Research Bulletin, Volume 121, March 2016
  4. Nouf Alrasheed, Marwa Al-Samhari, Salim Al-Rejaie, Raessa Ahmed, Nduna Dzimiri; Possible involvement of Janus Kinase-Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway in vitamin E-mediated anti-depressant-like effects in a rat depression model; Parkinsonism & Related Disorders, Volume 22, Supplement 2, January 2016
  5. Salim S. Al-Rejaie, Abdulaziz M. Aleisa, Hatem M. Abuohashish, Mihir Y. Parmar, Mohammad S. Ola, Abdulaziz A. Al-Hosaini, Mohammed M. Ahmed. Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy. Neurol Res. 2015;37(10):924-33
  6. A.J. Fatani, K.A. Al-Hosaini, M.M. Ahmed, H.M. Abuohashish, M.Y. Parmar, S.S. Al-Rejaie. Carvedilol Attenuates Inflammatory Biomarkers and Oxidative Stress in a Rat Model of Ulcerative colitis. Drug. Dev. Res., 76 (4) (2015), pp. 204–214.
  7. Hafez MM, Al-Shabanah OA, Al-Rejaie SS, Al-Harbi NO, Hassan ZK, Alsheikh A, Al Theyab AI, Aldelemy ML, Sayed-Ahmed MM. Increased hypermethylation of glutathione s-transferase p1, DNA-binding protein inhibitor, death associated protein kinase and paired box protein-5 genes in triple-negative breast cancer saudi females. Asian Pac J Cancer Prev, 2015; 16, 541-9.
  8. Salim S. Al-Rejaie, Hatem M. Abuohashish, Mohammed M. Ahmed, Aws S. Arrejaie, Abdulaziz M. Aleisa, Shakir D. AlSharari. Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats. Neurosciences 2015; Vol. 20 (2): 115-123 
  9. FATANI AJ., AL-REJAIE SS., ABUOHASHISH HM., AL-ASSAF A., PARMAR MY., OLA MS., AHMED MM. Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats. Exp. Ther. Med., 2015, 9, 1670-1678.
  10. Mohamed M Hafez, Naif O Al-Harbi, Ali Rashed Al-Hoshani, Khaled A Al-Hosaini, Shakir D Al Shrari, Salim S Al Rejaie, Mohamed M Sayed-Ahmed, Othman A Al-Shabanah. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Biol Res 2015 11;48:30.
  11. Amal J. Fatani, Salim S. Al-Rejaie, Hatem M. Abuohashish, Abdullah Al-Assaf, Mihir Y. Parmar, Mohammed M. Ahmed. Lutein Dietary Supplementation Attenuates Streptozotocin-induced testicular damage and oxidative stress in diabetic rats. BMC Complementary and Alternative Medicine 2015, 15:204
  12. Mohammad Shamsul Ola, Mohammed M. Ahmed, Rehan Ahmad, Hatem M. Abuohashish, Salim S. Al-Rejaie, Abdullah S. Alhomida. Neuroprotective effects of rutin in streptozotocin-induced diabetic rat retina. Journal of Molecular Neuroscience. 2015; 56(2):440-8
  13. Hafez MM, Alhoshani AR, Al-Hosaini KA, Alsharari SD, Al Rejaie SS, Sayed-Ahmed MM, Al-Shabanah OA. SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients. Asian Pac J Cancer Prev. 2015;16(14):5807-15.
  14. Abuohashish HM, Ahmed MM, Al-Rejaie SS, Eltahir KE. The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model. Acta Pharmacol Sin. 2015; 36: 209–220.
  15. AlSharari SD, Al-Rejaie SS, Abuohashish HM, Aleisa AM, Parmar MY, Ahmed MM.Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats.Trop J Pharm Res. 2014; 13:1429-36.
  16. Aleisa A, S. Al-Rejaie, H. Abuohashish, M. Ola, M. Parmar, M. Ahmed. Gymnema sylvestre protects against experimentally-induced colitis via its anti-inflammatory and antioxidant properties in rats. BMC Complementary and Alternative Medicine, 2014, 14(1):49.
  17. M.M. Hafez, O.A. Al-Shabanah, N.O. Al-Harbi, M.M. Al-Harbi, S.S. Al-Rejaie, S.M. Alsurayea, M.M. Sayed-Ahmed. Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4. Oxid. Med. Cell. Longevity (2014), p. 893212
  18. Abdulaziz M Aleisa, Salem S Al-Rejaie, Hatem M Abuohashish, Mohammed S Ola, Mihir Y Prmar and Mohammed M Ahmed (2014) Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats. BMC Complementary and Alternative Medicine doi: 10.1186/1472-6882-14-49.
  19. M. Ola, A. Aleisa, S. Al-Rejaie, H. Abuohashish, M. Parmar, A. Alhomida, M. Ahmed. Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats. Neurological Sciences, 2014, DOI 10.1007/s10072-014-1628-5
  20. Al-Shabanah OA, Hafez MM, Hassan ZK, Sayed-Ahmed MM, Abozeed WN, Al-Rejaie SS and Alsheikh AA: Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol J. 10:343–352. 2013
  21. Al-Rejaie SS, Abuohashish HM, Al-Enazi MM, Al-Assaf AH, Parmar MY, Ahmed MM. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World Journal of Gastroenterology. 2013; 19(34): 5633-5644.
  22. Mihir Parmar, Purvi Shah, Vaishali Thakkar, Salim Al-Rejaie, Tejal Gandhi. Hepatoprotective potential of Methanolic Extract of Vetiveria Zizanioides Roots against Carbon Tetrachloride-Induced Acute Liver Damage in Rats. Digest Journal of Nanomaterials & Biostructures. 2013; 8 (2): 835-844.
  23. Abdulaziz M. Aleisa, Salim S. Al-Rejaie, Hatem M. Abuohashish, Mohammed M. Ahmed, Mihir Y. Parmar.  Nephroprotective role of Morin against experimentally-induced diabetic nephropathy. Digest Journal of Nanomaterials & Biostructures. 2013; 8 (1): 395-401.
  24. Hatem M. Abuohashish, Salim S. Al-Rejaie, Khaled A. Al-Hosaini, Mihir Y. Parmar, Mohammed M. Ahmed. Alleviating effects of morin against experimentally-induced diabetic osteopenia. Diabetology & Metabolic Syndrome. 2013; 5 (5): 1-8.
  25. Salem S Al-Rejaie, Abdulaziz M Aleisa, Mohamed M Sayed-Ahmed, Othman A AL-Shabanah, Hatem M Abuohashish, Mohammed M Ahmed, Khaled A Al-Hosaini and Mohamed M Hafez. Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. Complementary and Alternative Medicine. 2013; 13 (136): 1-9.
  26. M. Shamsul Ola, Mohammed M. Ahmed, Hatem M. Abuohashish,  Salim S. Al-Rejaie, Abdullah S. Alhomida Telmisartan Ameliorates Neurotrophic Support and Oxidative Stress in the Retina of Streptozotocin-Induced Diabetic Rats. Neurochemical Research. 2013; 38 (8): 1572-1579.
  27. Salim S. Al-Rejaie. Thymoquinone Treatment Alleviate Ovariectomy-Induced Hepatic Oxidative Damage in Rats. Journal of Applied Pharmaceutical Science. 2013; 3 (06): 126-131.
  28. Dar MS, Al-Rejaie S. Tonic modulatory role of mouse cerebellar α- and β-adrenergic receptors in the expression of ethanol-ataxia: Role of AC-cAMP. Behavioural Brain Research, Volume 241, 15 March 2013, Pages 154–160.
  29. Mohamed Mohamed Sayed-Ahmed, Mohamed Mahmoud Hafez, Othman Abdualla Al-Shabanah, Salim Salih Al-Rejaie, Abdulaziz Mohamed Aleisa, Abdulmalik Alsheikh, Abdurrahman Ibrahim Al Diab, Mohammad Hamad AL-Akeely. Increased Expression of Biological Markers as Potential Therapeutic Targets in Triple-Negative Breast Cancer Saudi females. Tumori. 2012, under process
  30.  Mihir Y. Parmar, Purvi A. Shah, Vaishali T. Thakkar, Salim S. Al-Rejaie, Tejal R. Gandhi. Hepatoprotective effect of amomum subulatum roxb seeds on carbon tetrachloride-induced liver damage in rats. IOSR Journal of Pharmacy. 2(5) 2012.
  31. Abdulaziz M. Aleisa, Hatem M. Abuohashish, Mohammed M. Ahmed, Salim S. Al-Rejaie, Osama A. Alkhamees and Abdulaziz S. Alroujayee. Ameliorative effects of rutin and ascorbic acid combination on hypercholesterolemia-induced hepatotoxicity in female rats. African Journal of Pharmacy and Pharmacology. 2013; 7(6), pp. 280-288
  32. Mohamed M. Sayed-Ahmed, Mohamed M. Hafez, Meshan Lafi Aldelemy, Abdulaziz M. Aleisa, Salem S.Al-Rejaie, Khaled A. Al-Hosaini, Naif O. Al-Harbi, Mohamed M. Al-Harbi, and Othman A. Al-Shabanah. Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model. Oxidative Medicine and Cellular Longevity. Volume (2012), page 1-9.
  33. Al-Rejaie SS, Abuohashish HM, Ahmed MM, Aleisa AM, Alkhamees O. Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage by Gymnema sylvestre in male Wistar albino rats. Pharm Biol. 2012 Dec;50(12):1542-50.
  34. Salim S. Al-Rejaie. Effect of Oleo-gum-resin on Ethanol-induced Hepatotoxicity in Rats. J. Med. Sci. 12 (1). 2012.
  35. Salim S. Al-Rejaie, Hatem M. Abuohashish, Mohammed M. Ahmed, Abdulaziz M. Aleisa, Abdulaziz S. Alroujayee and Osama A. Alkhamees. Immobilization stress-induced oxidative damage and its amelioration with green and black teas. African Journal of Pharmacy and Pharmacology, 2012, Vol. 6(8), pp. 538 – 545.
  36. Al-Rejaie SSAbuohashishHM, Alkhamees OA, Aleisa AM,Alroujayee AS. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health Dis.2012;11(1):41
  37. Ihab M. Moussa, Ashgan M. Hessan, Abdulaziz M. Aleisa, Abdullah A. Al-Arfaj, Mounier M. Salem-Bekhit, Salim A. Alrejai. Protective efficacy of immunoglobulins Y prepared against Cerastes cerastes snake venom in the Kingdom of Saudi Arabia. Saudi Med J 2012; 33 (8): 846-851
  38. Hafez MM, Hassan ZK, Zekri AR, Gaber AA, Al Rejaie SS, Sayed-Ahmed MM, Al Shabanah O. MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients. Asian Pac J Cancer Prev. 2012;13(2):591-8.
  39. Al-Shabanah OA, Aleisa AM, Hafez MM, Al-Rejaie SS, Al-Yahya AA, Bakheet SA, Al-Harbi MM, Sayed-Ahmed MM. Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model. Oxid Med Cell Longev; 2012: Page 1-7.
  40. Moussa I. M., Ashgan M. H., Abdulaziz M. Aleisa, Abdullah A. Al-Arfaj and Salim A. Rejaie. Evaluation of the protective efficacy of immunoglobulin Y (IgY- antibodies) prepared against Walterinnesia aegyptia snake venom in Saudi Arabia. African Journal of Biotechnology 2012, Vol. 11(72), pp. 13726-13731.
  41. Mounir M. Salem-Bekhit, Ihab Mohamed Ibrahim Moussa, Muharram M. M. Ahmed Mahmoud Elsherbini and Salim AlRejaie. Increasing prevalence of high-level gentamicin resistant enterococci: An emerging clinical problem. African Journal of Microbiology Research. 5(31) pp. 5713-5720, 2011.
  42. Marwah Mohamed, I. M. Moussa, Kh. F. Mohamed, Ahmed Samir, E. A. Nasr, M. H. Ashgan, Salim  AlRejaie and M. E. Hatem. BACTEC MGIT 960 TM system for screening of Mycobacterium tuberculosis complex among cattle. African Journal of Biotechnology. 10(63), pp. 13919-13923, 2011.
  43. A.M. Aleisa, G. Helal, I.A. Alhaider, K.H. Alzoubi, M. Srivareerat, T.T. Tran, S.S. Al-Rejaie, and K.A. Alkadhi. Acute Nicotine Treatment Prevents REM Sleep Deprivation-Induced Learning and Memory Impairment in Rat. HIPPOCAMPUS 21:899–909 (2011).
  44. Alshabanah OA, Hafez MM, Al-Harbi MM, Hassan ZK, Al-Rejaie SS, Asiri YA, Sayed-Ahmed MM.  Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation. Oxidative  Medicine and Cellular Longevity. 2010;3(6):428-33.
  45. Mansour, Mahmoud A; Bekheet, Saleh A; Al-Rejaie, Salim S; Al-Shabanah, Othman A; Al-Howiriny, Tawfeq A; Al-Rikabi, Ammar C; Abdo, Ayman A. Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepato  carcinogenesis model. Biofactors. 2010;36 (6) 483-90.
  46. Sayed-Ahmed MM, Aleisa AM, Al-Rejaie SS, Al-Yahya AA, Al-Shabanah OA, Hafez MM, Nagi MN.  Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through  antioxidant signaling. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2010;3(4) 254-261.
  47. Al-Shabanah OA, Aleisa AM, Al-Yahya AA, Al-Rejaie SS, Bakheet SA, Fatani AG, Sayed-AhmedMM. Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in  gentamicin-induced acute renal failure in rats. Nephrol Dial Transplant. 2010;25(1).
  48. Sayed-Ahmed MM, Al-Shabanah OA, Hafez MM, Aleisa AM, Al-Rejaie SS., Inhibition of gen eexpression of heart fatty acid binding protein and organic cation/carnitine transporter indoxorubicin cardiomyopathic rat model. Eur J Pharmacol. 2010, Aug 25;640(1-3):143-9.
  49. Al-Rejaie S.S., Effect of Green and Black Teas on Immobilization Induced Stress in Male Wistaralbino Rats. International Journal of Pharmacology. 2009; 5(2): 137-145
  50. Adel R. A. Abd-Allah, Gouda K. Helal, Abdulaziz A. Al-Yahya, Abdulaziz M. Aleisa, Salim S. Al-Rejaie, Abdulhakeem A. Al-Majed and Saleh A. Al-Bakheet, Pro-inflamatory and oxidative stress pathway which compromise sperm motility and survival may be altered by L-carnitine, Oxidative Medicine and Cellular Longevity. 2009;2(2):73-81.
  51. Al-Rejaie S.S., Inhibition of Ethanol-Induced Gastric Mucosal Damage by Carvedilol in Male Wistar albion Rats: Possible Biochemical Changes, International Journal of Pharmacology. 2009;5(2): 146-154
  52. Attia SM, Aleisa AM, Bakheet SA, Al-Yahya AA, Al-Rejaie SS, Ashour AE, Al-Shabanah OA.  Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan. Environ Mol Mutagen. 2009;50(2):145-51.
  53. Gouda K. Helal, Abdulaziz M. Aleisa, Omayma K. Helal, Salim S. Al-Rejaie, Abdulaziz A. Al-Yahya, Abdulhakeem A. Al-Majed and Othman A. Al-Shabanah. Metallothionein induction reduces caspase-3 activity and TNFα levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats. Oxidative Medicine and Cellular Longevity. 2009;2(1):26-35.
  54. Salim S. Al-Rejaie, Abdulaziz M. Aleisa, Abdulaziz A. Al-Yahya, Saleh A. Bakheet, Abdulmalik Alsheikh, Amal G. Fatani, Othman A. Al-Shabanah and Mohamed M. Sayed-Ahmed. Progression of Diethylnitrosamine-Induced hepatic carcinogenesis in Carnitine-Depleted Rats. World Journal of Gastroenterology. 2009;15(11): 1373-1380.
  55. Taslim N, Al-Rejaie S, Saeed Dar M. Attenuation of ethanol-induced ataxia by alpha(4)beta(2)nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction. Neuroscience. 2008; 157(1):204-13.
  56. Aleisa AM, Al-Rejaie SS, Bakheet SA, Al-BekairiAM, Al-Shabanah OA, Al-Majed AA, Al-Yahya AA,Qureshi S. Protective effect of metformin on cardiac and hepatic toxicity induced by adriamycin in  swiss albino mice. Asian Journal of Biochemistry. 2008; 3(2):99-108.
  57. Mahmoud A mansour, Saleh A Bakheet, Abduaziz M Aleisa, Salim S Al-Rejaie, Abdulaziz A ALYahya,  Mubarak El-Ameen and Othman A Al Shabana. Protective effect of 6-Gingerol against cardiotoxicity  iduced by doxorubicin. The open Pharmacology journal. 2008; 2:20-23.
  58. Aleisa, A.M., A.A. Al-Majed, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, O.A. Al-Shabanah, andM.M. Sayed-Ahmed, Reversal of cisplatin-induced carnitine deficiency and energy starvation bypropionyl-L-carnitine in rat kidney tissues. Clin  Exp  Pharmacol Physiol., 2007; 34(12): p. 1252-9.
  59. Aleisa, A.M., S.S. Al-Rejaie, S.A. Bakheet, A.M. Al-Bekari, O.A. Al-Shabanah, A. Al-Majed, A.A.Al-Yahya, and S. Qureshi, Effect of metformin on clastogenic and biochemical changes induced by  adriamycin in Swiss albino mice. Mutat Res, 2007; 634:93-100.
  60. Al-Rejaie S.S., Bakheet SA, Al-Harbi MM, Al-Bekari AM, Al-Shabanah OA, Al-Majed A, Al-YahyaAA, Qureshi S., Cytotoxic, Biochemical and Anti-Tumor Activity of Camel Urine on Ehrlich Ascites Carcinoma Cell-Bearing Swiss Albino Mice. The Journal of Research and Education in Indian Medicine. 2007.
  61. Al-Majed, A.A., M.M. Sayed-Ahmed, A.A. Al-Yahya, A.M. Aleisa, S.S. Al-Rejaie, and O.A. Al- Shabanah, Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacol Res., 2006; 53(3): p. 278-86.
  62. Al-Rejaie SS, Dar MS. Antagonism of ethanol ataxia by intracerebellar nicotine: Possible modulation by mouse cerebellar nitric oxide and cGMP. Brain Research Bulletin. 2006; 69(2):187- 96.
  63. Al-Rejaie SS, Dar MS. Behavioral interaction between nicotine and ethanol: possible modulation by mouse cerebellar glutamate. Alcohol ClinExp Res. 2006; 30(7):1223-33.
  64. Al-Rejaie SS, Dar MS. Possible role of mouse cerebellar nitric oxide in the behavioral interaction between chronic intracerebellar nicotine and acute ethanol administration: Observation of crosstolerance. Neuroscience. 2006; 138(2):575-585.
more of publication
  1. Fatani AJ, Alrojayee FS, Parmar MY, Abuohashish HM, Ahmed MM, Al-Rejaie SS; Myrrh attenuates oxidative and inflammatory…