Skip to main content
User Image

V.S. Periasamy M.Sc., Ph.D

Associate Professor

Associate Professor of Nano-Biotechnology

كلية علوم الأغذية والزراعة
AA40, Nanobiotechnology and Molecular Biology lab, Department of Food Science and Nutrition

Identification of Nanoscale Ingredients in Commercial Food Products and their Induction of Mitochondrially Mediated Cytotoxic Effects on Human Mesenchymal Stem Cells

Al-Warthan, Jegan Athinarayanan, Ali A. Alshatwi, Vaiyapuri S. Periasamy andAbdulrahman A. . 2015

Titanium dioxide (E171) and silicon dioxide (E551) are common additives found in food products, personal-care products, and many other consumer products used in daily life. Recent studies have reported that these food additives (manufactured E171 and E551) contain nanosized particles of less than 100 nm. However, the particle size distribution and morphology of added TiO2 and SiO2 particles are not typically stated on the package label. Furthermore, there is an increasing debate regarding health and safety concerns related to the use of synthetic food additives containing nanosized ingredients in consumer products. In this study, we identified the size and morphology of TiO2and SiO2 particles in commercially available food products by using transmission electron microscope (TEM). In addition, the in vitrotoxicological effects of E171 and E551 on human mesenchymal stem cells (hMSCs), an adult stem cell-based model, were assessed using the MTT assay and a flow cytometry-based JC-1 assay. Our TEM results confirmed the presence of nanoscale ingredients in food products, and the in vitro toxicology results indicated that the nanoscale E171 and E551 ingredients induced dose-dependent cytotoxicity, changes in cellular morphology, and the loss of mitochondrial trans-membrane potential in hMSCs. These preliminary results clearly demonstrated that the nanoscale E171 and E551 particles had adverse effects on hMSCs by inducing oxidative stress-mediated cell death. Accordingly, further studies are needed to identify the specific pathway involved, with an emphasis on differential gene expression in hMSCs.

Publication Work Type
Magazine \ Newspaper
Journal of Food Science
more of publication

The SiO2 synthesized in bulk form, adopting the conventional methods…


The use of engineered nanoparticles (NPs) across multiple fields and applications has rapidly increased over the last decade owing to their unusual properties. However, there is an increased need…

by Vaiyapuri S. Periasamy, Jegan Athinarayanan, Mohammad Alhazmi, Khalid A Alatiah andAli A. Alshatwi

Titanium dioxide (TiO2) is a common additive in many foods, pigments, personal care products, and other consumer products used in daily life.

by Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ahmed M. Al-Hadi, Fahad Al Juhaimi, Ali A. Alshatwi