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Nahed Nasser Eid El-Sayed

Associate Professor

Associate Professor of Organic Chemistry

كلية العلوم
Building 5, 3rd floor, office, T253
publication
Journal Article
2016

Synthesis, Antiphospholipase A2, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones

El-Sayed, Nahed N. E. . 2016

benzo[d][1 3]oxazin-4-one aroylhydrazide N-acylhydrazones hydrazones benzylidene hydrazides

Some novel hydrazone derivatives 6ao were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The inhibitory potential against two secretory phospholipase A2 (sPLA2), three protease enzymes and eleven bacterial strains were evaluated. The results revealed that all compounds showed preferential inhibition towards hGIIA isoform of sPLA2 rather than DrG-IB with compounds 6l and 6e being the most active. The tested compounds exhibited excellent antiprotease activity against proteinase K and protease from Bacillus sp. with compound 6l being the most active against both enzymes. Furthermore, the maximum zones of inhibition against bacterial growth were exhibited by compounds; 6a6m, and 6o against P. aeruginosa6a6b6d6f6l6m6n, and 6oagainst Serratia6k against S. mutans; and compounds 6a6d6e6m, and 6n against E. feacalis. The docking simulations of hydrazones 6ao with GIIA sPLA2, proteinase K and hydrazones 6ae with glutamine-fructose-6-phosphate transaminase were performed to obtain information regarding the mechanism of action.

Publication Work Type
Research
Volume Number
21
Issue Number
12
Magazine \ Newspaper
Molecules
Pages
1664
more of publication
publications

Some novel hydrazone derivatives 6ao were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and…

by Nahed N. E. El-Sayed
2016
publications

This study comprises the synthesis and characterization of twenty thiazole-derived carbamates (3a-e), N-substituted amides (8a-h) and carboxamide (10) from 2-aminothiazoles (1a, b) via…

by Nahed Nasser E. El-Sayed, Nawal Ali AL-Balawi, Ahmed M. Alafeefy Monirah A. AL ALShaikh, and Khalid Mohammed Khan
2016
publications

This work describes different strategies to desymmetrise 1,4-cyclohexadiene
derivatives with concomitant formation of a quaternary stereogenic centre.
Chapter 1 briefly describes the…

by Nahed El-Sayed
2015
Published in:
Lambert academic Publishing