Dose-inverted neurotoxicity: La2O3 nanoparticles cause redox dysregulation at low concentrations but excitotoxic catastrophe at high doses
This study investigated the effects of lanthanum oxide nanoparticles (La2O3 NPs) on cognitive and motor functions in female mice. We used behavioral tests, biochemical analysis, and tissue examination. Our findings indicate that neurotoxicity is dose-dependent, with distinct mechanisms at play. Low doses (60 mg/kg) caused severe oxidative stress, increasing a key damage marker (MDA) by 40-80 times and depleting antioxidants (glutathione) in the blood. These doses also led to the accumulation of pro-oxidant metals (Fe, Mn, Cu, Ti) and a reduction in brain calcium levels, as determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). At moderate doses, mice exhibited hyperactive movement but normal muscle strength, indicating a brain-specific effect. In contrast, high doses (300 mg/kg) triggered a different pattern of damage. This included a harmful calcium-potassium imbalance, disruption of …
There are still not many meaningful alternatives to converting too-nitrogenated water into ammonia. This is mostly because it requires highly active and long-lasting catalysts.
This study investigated the effects of lanthanum oxide nanoparticles (La2O3 NPs) on cognitive and motor functions in female mice. We used behavioral tests, biochemical analysis, and tissue…
This research introduces a new hybrid material for potential cancer treatment. It combines carbon nanotubes decorated with copper nanodots and Arabic gum through an electroless reduction…