Electrochemical Sensors for Berberine Hydrochloride Determination in Commercial Products and Bio-Fluids
The present study describes the development of three electrochemical sensors conducted by the
interaction of berberine hydrochloride (BRB) with phosphotungestic acid (plastic membrane), sodium
tetraphenyl borate (coated wire), and ammonium reineckate (coated graphite) sensors. Under optimum
experimental conditions the effect of membrane content, type of solvent mediator, soaking time,
hydrogen ion concentration of the test solutions and the estimation of the analyte in the presence of
foreign species were studied. The data confirmed that the developed sensors gave potential responses
of 54.10 ± 0.5, 57.00 ± 0.5 and 59.00 ± 0.5 mV decade-1
at ambient temperature for (berberine–
phosphotungstate, BRB-PT), (berberine–tetraphenylborate, BRB-TPB) and (berberine–reineckate,
BRB-AR) sensors, respectively, over drug concentration ranges of 1.0×10-7
- 1.0×10-3
, 1.0×10-8
-
1.0×10-2
and 1.0×10-7
- 1.0×10-2 mol L-1 with lower detection limits 5.0×10-8
, 5.0×10-9
and 5.0×10-8
mol L-1
for the above suggested sensors, respectively. The suggested sensors provide high selectivity,
precise and sensitivity for the determination of BRB within the average pH range 3-9. Validity of the
method was performed for the suggested electrochemical probe following ICH guidelines. The
suggested sensors were favorably exploited for the estimation of BRB in commercial products and biofluids.
Due to massive industrial development, organic and inorganic wastes are very common in most industrial efuents from the pharmaceutical industry. Even in low concentrations, they are very dangerous…
Recently, carbon dots (CDs) have been extensively investigated as potential tools for numerous applications. Modified lignin-based CDs have been synthesized and used in the field of drug detection…
Recently, dual-mode techniques have garnered considerable attention and have been shown to be effective approaches for biomedical analysis and environmental monitoring.