Skip to main content
User Image

نائل محمود أبوطه

Associate Professor

عضو هيئة تدريس

كلية العلوم
كلية العلوم-كرسي أبحاث المنتجات الحيوية رقم المعمل AB85

Analysis of the chemical composition and in vitro cytotoxic activities of the essential oil of the aerial parts of Lavandula atriplicifolia Benth

Plants of the Lavandula genus have been widely used in folk and traditional medicine. The aim of this study was to evaluate the qualitative and quantitative chemical composition of the essential oil of the aerial parts of Lavandula atriplicifolia (EOAPLA) grown in Saudi Arabia and its potential cytotoxicity to cancer cell lines. The essential oil was characterized and quantified by GC–MS and GC-FID. The potential cytotoxicity of the essential oil was evaluated against colorectal (LoVo) and hepatocellular (HepG2) carcinoma cell lines by using the MTT and lactate dehydrogenase (LDH) cytotoxicity assays. A total of 36 compounds were identified that constituted 92.3% of the total oil. The chemotype of the species was dominated by C-10 massoia lactone (46.65%) as the major compound followed by oxygenated monoterpenes (28.43%). This is the first report to describe the presence of the rare compound massoia lactone in the essential oils from Lavandula species. The data revealed that EOAPLA inhibited the growth of LoVo and HepG2 cells in a dose-dependent manner. Treatment with 10 μg/mL EOAPLA for 2 days resulted in significant damage to LoVo cells in comparison with the control. In contrast to the control cells, the LoVo cells showed morphological alterations such as cytoplasmic condensation, shrinkage, and the formation of debris. Moreover, EOAPLA treatment induced apoptosis in LoVo cells since it increased the expression of caspase 3/7. The cytotoxic and anti-proliferative properties of EOAPLA make it a good candidate for treatment of various cancers.

Publication Work Type
بحث
Publisher Name
Journal of King Saud University – Science
more of publication
publications

Cancer is reported to be the leading cause of death and illness worldwide. This research aims to evaluate the phytochemicals,

by Ahmed I. Alsayadi1 · Nael Abutaha1 · Bader O. Almutairi1 · Fahd A. Al‑Mekhlaf1 · Mohamed A. Wadaan1
2022
Published in:
Environmental Science and Pollution Research
publications
by Yahia Nasser Mabkhot , Abha ( SA ) ; Jamal Mohammed Ali Khaled , Riyadh ( SA ) ; Naiyf Sultan Helial Alaloi Alharbi , Riyadh ( SA ) ; Fahd Ali Nasr Mohammed , Riyadh ( SA ) ; Fahd Abdo Almekhlafi , Riyadh ( SA ) ; Nael Mahmmoud Abutaha , Riyadh ( SA ) ; S
publications

The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty…

by Ramzi A. Mothana, Fahd A. Nasr, Jamal M. Khaled, Omar M. Noman, Nael Abutaha, Adnan J. Al-Rehaily, Omar M. Almarfadi and Mine Kurkcuoglu
Published in:
open chemistry