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أمــل بنت محمد بن عبدالعزيز المحيميد

Associate Professor

استاذ مشارك- مساعدة وكيلة كلية العلوم للدراسات العليا والبحث العلمي

كلية العلوم
مبنى 5- الدور الثالث- مكتب رقم 185
publication
Journal Article
2014

Spectrofluorimetric analysis of gemifloxacin mesylate in pharmaceutical formulations

, Amal M. Al-Mohaimeed*, Salma A. Al-Tamimi, . 2014

ورقة بحثيه

: A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of gemifloxacin mesylate (GFX) in tablets. The method is based on measuring the native fluorescence of GFX in isopropanol at 400nm after excitation at 272nm. The fluorescence–concentration plot was rectilinear over the range of 0.01–0.50mg/mL with a lower detection limitof1.19ng/mL andquantification limitof3.6ng/mL.The methodwasfully validatedand successfully appliedtothedetermination of GFX tablets with an average percentage recovery of 99.650.532. The method was extended to the stability study of GFX. The drug was exposed to acidic, alkaline, oxidative and photolytic degradation according to International Conference on Harmonizationguidelines.TherateofGFXdegradationwasfoundatitshighestinacidicconditions,andinitslowestintheneutral one. However, it was stable under dry heat and photolytic
 

Publication Work Type
دكتوراه
Volume Number
29
Issue Number
29
Magazine \ Newspaper
Luminescence
Pages
127-131
more of publication
publications
by 1. Mahmood, Mudasir; Iqbal, Shahid; Jamshaid, Muhammad; Kalsoom, Ambreen; Amal M. Al-Mohaimeed; Iqbal, Rashid; Bibi, Firdous; Raza, Qasim; Elshikh, Mohamed Soliman
2024
publications
by Abdulhadi Hamad Al-Marri, Fatma Janene, Ali Moulahi, Amal T. Mogharbel, Eida S. Al-Farraj, Amal M. Al-Mohaimeed & Issam Mjejri
2023