Synthesis, Kinetics, Reaction Mechanism and Bio-activity Assays of a Dimeric Palladium Complex
A dimer of Pd(II), [(bpy)Pd(μ-OH)2Pd(bpy)]2+, (complex 1) (where bpy=2,2′-bipyridyl) has been synthesized at physiological pH (7.4) and characterized by electronic spectroscopy, electrospray ionization mass spectrometry (ESI-MS) spectroscopy, and Fourier transform infra red (FT-IR) analysis. Reactionkineticsof1withglycine(L1H), L-glutamic acid (L2H), and L-arginine (L3H) were investigated in an aqueous medium at pH of 7.4 and constant ionic strength via a spectrophotometer as a function of temperature and different concentrations of substrate-complex and ligand. The interactions were supported by two discrete successive steps, i.e., ligand-dependent and ligand-independent steps. The equilibrium constant of complex formation(outer-sphere association) and the rate constant during complex-substrate−ligand interaction were calculated. The Eyring equation was applied to evaluate activation factors (ΔH‡ and ΔS‡), and associative mechanisms of all reactions were proposed. Thermodynamic parameters (ΔH°andΔS°)were also estimated from the standard plot of ln KE against103/T. Spectroscopic titration of 1at pH 7.4 in Tris−HCl buffer with calf thymus DNA, electronic emission titration with ethidium bromide (EtBr), antimicrobial activities, and an agarose gel electrophoresis run of 1 on pBR322 plasmid DNA have shown strong evidence of anti cancer activity. Moreover, it has nontoxic water molecules as leaving groups
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A dimer of Pd(II), [(bpy)Pd(μ-OH)2Pd(bpy)]2+, (complex 1) (where bpy=2,2′-bipyridyl) has been synthesized at physiological pH (7.4) and characterized by electronic spectroscopy, electrospray…