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Abdul Khader Mohammed

Lecturer

Research Associate

كلية العلوم
Building 5, Floor 2, Room 2A-51
publication
Journal Article
2016

SNPs in FNDC5 (irisin) are associated with protection from obesity and modulation of glucose and lipid metabolism.

MS, Al-Daghri NM, Mohammed AK, Al-Attas OS, , Clerici M, Alenad A, Alokail . 2016

BACKGROUND:

Irisin is a recently identified myokine that plays an important role in preventing obesity and insulin resistance. We investigated whether the common FNDC5 (irisin precursor) gene variants influence susceptibility to obesity and type 2 diabetes (T2D) and verified the impact of FNDC5 gene variants on serum irisin levels, glucose and lipid metabolism in a Saudi population.

METHODS:

Genomic DNA from 814 (394 T2DM and 414 controls) subjects were genotyped for the five common SNPs (rs3480A/G, rs1746661G/T, rs1298190A/G, rs726344A/G and rs1570569G/T) of the FNDC5 gene using the TaqMan genotyping assay. Biochemical parameters and hematic concentrations of irisin and insulin as well as anthropometric indices were collected.

RESULTS:

Serum irisin levels were higher in T2DM patients compared to controls (p < 0.0001). Analyses of FNDC5 SNPs showed that: 1) The rs3480 GG associates with decreased risk of obesity (p = 0.005; odds ratio: 0.48) and lower body mass index (BMI) values (p = 0.03). In addition, GGAAG was identified as the protective haplotype against risk of obesity (p = 0.001; odds ratio: 0.23). 2) The rs1746661 G allele associates with higher triglyceride (TG) levels (p = 0.019). 3) The rs157069 TT genotype associates with higher fasting insulin (p = 0.029) and HOMA-IR (p = 0.002) as well as with lower circulating irisin levels (p = 0.016).

CONCLUSIONS:

SNPs in FNDC5 gene correlates with obesity and glucose-lipid metabolism possibly because they modulate the serum levels of irisin.

Volume Number
15
Issue Number
54
Magazine \ Newspaper
Lipids Health Dis
Pages
1 to 8
more of publication
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A possible role of Snap25 polymorphisms in type 2 diabetes mellitus (T2DM) was evaluated by analyzing three SNPs within intron 1 in a region known to affect the gene expression in vitro.

by Al-Daghri NM, Costa AS, Alokail MS, Zanzottera M, Alenad AM, Mohammed AK, Clerici M, Guerini FR
2016
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by Krishnaswamy S, Mohammed AK, Amer OE, Tripathi G, Alokail MS, Al-Daghri NM.
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by Al-Daghri NM, Mohammed AK, Al-Attas OS, , Clerici M, Alenad A, Alokail MS
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