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أ. د. عبدالرحمن بن عبدالعزيز المهيزع Prof. Abdulrahman A. Almehizia

Professor

Professor of Medicinal Chemistry

كلية الصيدلة
كلية الصيدلة (مبنى رقم 23) الدور الثاني مكتب رقم 2 أ 133
publication
Journal Article
2013

Latest advances in the multiple myeloma drug research: from molecular signaling pathways to small molecules development

A, Almehizia . 2013

Multiple myeloma (MM) is an uncontrolled differentiation of plasma B cells and the deposits in the bone marrow. MM accounts for 10% of blood cancers and nearly more than 22,000 new cases are diagnosed yearly in the United States. MM is associated with aggressive clinical manifestations including hematological and metabolic diseases. In addition, bone complications are common in more than 60% of cases such as osteoporosis, bone lesions and fractures. Complicated molecular signaling pathogenesis pathways are involved in the MM disease which accounts for the difficult disease control. MM remains an incurable disease despite the recent discovery of novel proteasome inhibitor (Bortezomib). This review addresses the molecular signaling pathways associated with MM progression and survival, and further demonstrates the mechanisms, molecular targets, and the development of current anti-MM agents. Also, we address the recent discoveries in MM molecular targeting as well as the recent discoveries and development of small molecules in patents and/or clinical trials

Volume Number
7
Magazine \ Newspaper
Current Trends in Medicinal Chemistry
Pages
105-133
more of publication
publications

Apurinic/apyrimidinic endonuclease-1/redox effector factor-1 (APE-1) is a critical component of base excision repair that excises abasic lesions created enzymatically by the action of DNA…

by Zhiwei F, Stanton K, Close D, Wang L, Srinivasan A, Almehizia A, Iyer P, Xie XQ, Johnston P, Gold B
2015
publications

Multiple myeloma (MM) is an uncontrolled differentiation of plasma B cells and the deposits in the bone marrow. MM accounts for 10% of blood cancers and nearly more than 22,000 new cases are…

by Almehizia A, Yang P, Wang L, Xie XQ
2013
publications

Cannabinoid receptors have gained increasing attention as drug targets for developing potential therapeutic ligands. Here, we report the discovery and optimization of triaryl sulfonamides as a…

by Yang P, Wang L, Feng R, Almehizia A, Tong Q, Myint KZ, Ouyang Q, Alqarni M, Xie XQ
2013