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Mona S Alwahaibi منى بنت سليمان الوهيبي

Professor

Faculty member

كلية العلوم
Building 5 Third Floor Office 299
publication
Journal Article
2023

Chemical screening and mosquitocidal activity of essential oil derived from Mikania scandens (L.) Willd. against Anopheles gambiae Giles and their non-toxicity on mosquito predators

https://doi.org/10.1080/26895293.2023.2169959

Mikaniaessential oilsphyto-chemical slarvicidegut enzyme

In-vitro chemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens (L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiae was investigated. GC-MS analysis evidenced a total of 12 bio-active compounds, and maximum at α-bisabolol (39.34%) followed by stigmasterol (13.45%) respectively. The larvicidal activity of CVO-MS against the malarial vector An. gambiae evidenced that the mortality rate was prominent at the maximum dosage of 1000 ppm. The Median Lethal Concentration (LC50) of CVO-MS was established at 488 ± 2.45 ppm, respectively. Enzyme inhibition assay showed that the CVO-MS delivers a significant upsurge in the level of CYP450, GST, and a decline in the level of α-β carboxylesterase activity in both the third and fourth instar (p ≤ 0.0001). The gut-histological examination of CVO-MS showed that there is severe damage in the mid-gut tissues, especially epithelial layer (EL), gut-lumen (GL), and peritrophic membrane (pM). The non-target screening against the mosquito predators (A. bouvieri, D. indicus, and third instar larvae of Tx. splendens) suggests that CVO-MS showed less toxicity as compared to Pestanal® (1 ppm) respectively. The present study has paved a new insight in understanding the bioactivity of CVO-MS as a potential larvicidal agent of malarial vector and non-toxic against mosquito predators.

Publishing City
South Korea
Magazine \ Newspaper
Environmental Toxicology and Health
more of publication
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The unpredictably changing climatic conditions, especially high temperatures, are putting a continuous
threat to sustainable cotton production. The current study was designed to investigate…

by Mona S.Alwhibi, Muhammad Irfan Yousaf
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Published in:
Journal of King Saud University – Science
publications

In-vitro chemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens (L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiae was…

by Radhakrishnan, N., Karthi, S, Raghuraman, P., Ganesan, R, Srinivasan, K, Edwin, E, Mona S. alwahibi
2023
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In the current times, nanotechnology has emerged as a field that promises scientific advancement with the manipulation, improvement, and application of near-atomic scale materials.Bimetallic…

by Mona S.Alwhibi, Khalid M.O.Ortashi, Awatif A.Hendi, M.A.Awad, Dina A.Soliman, MohamedEl-Zaidy
2022