CLS 223
Department : Medical Sciences
Course Number : CLS 223
Course Title : General Pathology
Credit Hours : 2 + 0 = 2
Course Description:
Upon completion of this course, the students will have the appropriate knowledge about the causes of cellular stress and the general pathologic responses to cellular stress, the circulatory disturbance, the basic immune reactions, the main immunopathologic processes, Disorders of growth and neoplasia.
CLS 223: Lectures Outline
Weeks Subjects
1. Introduction
- Define pathology
- Define disease, study of disease
2. Etiology
- Predisposing and determining factors
- Pathological anatomy (lesion)
- Manifestation of the disease
- Pathological physiology
-Diagnosis
3.Causes of cell damage (stress)
Cellular response to stress
Degeneration
Necrosis and gangrene
4-5.Inflammation (definition, nomenclature and causes)
Pathogenesis, local vascular changes of acute inflammation
The inflammation exudates, inflammatory cells and chemical mediators and sequelae of acute inflammation
- special types of acute inflammation
- types of chronic inflammation
general effects of inflammation
6.Infection
- factors influencing establishment of infection
- factors influencing the course of infection
- mechanism by which disease is produced: bacterial, viral and opportunistic infections
7. Healing
- wound healing
- factors influencing wound healing
- complications
- healing in special situations e.g. kidney, liver muscle, nervous tissue and bone
8-9.Circulatory Disturbances
- hyperemia
- congestion
- obstruction
- causes: thrombosis, embolism
- effect of vascular obstruction leading to oedema
- heamorrhage
10-11. Immunology
- specific and non-specific immunity
- immune response, antigen, antibodies, compliment, humoral cell mediated response
Diseases of the immune system
- hypersensitivity reactions
- auto-immune disease, tolerance
- mmune deficiency diseases
12. Disturbances of growth
- hyperplasia
- hypertrophy
- atrophy
-dysplasia
-metaplasia
13-14.Neoplasia
- definition and classifications
- general features of benign and malignant tumors
- effects and complication of benign and malignant tumors
-tumor of epithelial, connective, muscular and nervous tissues
- carcinogenesis
- brief discussion on diagnosis of tumors and treatment
Assessments:
First Mid Term Examination: 15
Second Mid Term Examination: 15
Laboratory Quizzes: 5
Mid Term Practical Examination: 5
Final Practical Examination: 20
Final Theoretical Examination: 40
References:
Emanuel Rubin, Essential Pathology, Lippincott Williams&Wilkins, Phiadelphia & London.