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الدكتور فهد بن ناصر المجحدي

Professor

المشرف على كرسي ابحاث كوفيد 19

كلية العلوم
قسم النبات و الاحياء الدقيقة / مكتب 2ب 49 الدور الثاني كلية العلوم مبنى 5
publication
Journal Article
2023

Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis

Journal of Infection and Public Health

breast cancer MMTV-like virus env gene expression invasive breast cancer LNM metastasis

MMTV causes mammary tumors in mice, and it is associated with invasive and aggressive forms of breast cancer in humans. However, the underlying mechanisms are yet unknown. We aimed to determine the MMTV-like virus (MMTV-LV) association with histological types of breast cancer, nodal involvement, and metastasis. First, 105 breast cancer biopsies and 15 disease-free biopsies were collected. Details of clinicopathological characteristics were retrieved from patients’ records. The status of MMTV-LV was already known for these biopsy samples. Associations of MMTV-LV prevalence with LNM status and metastatic history were determined. Next, quantitative PCR (qPCR) was used to quantify env gene mRNA in biopsies positive for MMTV-LV. Expression of the env gene was compared against different histopathological types of mammary tumor, LNM status, and metastasis by performing Ordinary One Way ANOVA followed by Tukey’s multiple comparisons test. MMTV-LV prevalence was found to have no significant association with LNM or metastatic history. As compared to normal control, expression of the env gene was significantly higher (>2.8 folds) in invasive samples (P-value: < 0.01). Expression was also higher (3.28 and 2.89 folds) in patient samples with LNM (P-value: 0.0006) or metastatic history (P-value: < 0.0001), respectively. We conclude that MMTV-LV prevalence is not associated with LNM status or breast cancer metastasis; samples with invasive phenotypes, nodal involvement, and metastasis exhibit significantly higher expression of the MMTV-like env gene.

Publication Work Type
Research
Publisher Name
Journal of Infection and Public Health
Volume Number
16
Issue Number
9
Pages
1396-1402
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