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الدكتور فهد بن ناصر المجحدي

Professor

المشرف على كرسي ابحاث كوفيد 19

كلية العلوم
قسم النبات و الاحياء الدقيقة / مكتب 2ب 49 الدور الثاني كلية العلوم مبنى 5
المنشورات
مقال فى مجلة
2023

Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis

Journal of Infection and Public Health

breast cancer MMTV-like virus env gene expression invasive breast cancer LNM metastasis

MMTV causes mammary tumors in mice, and it is associated with invasive and aggressive forms of breast cancer in humans. However, the underlying mechanisms are yet unknown. We aimed to determine the MMTV-like virus (MMTV-LV) association with histological types of breast cancer, nodal involvement, and metastasis. First, 105 breast cancer biopsies and 15 disease-free biopsies were collected. Details of clinicopathological characteristics were retrieved from patients’ records. The status of MMTV-LV was already known for these biopsy samples. Associations of MMTV-LV prevalence with LNM status and metastatic history were determined. Next, quantitative PCR (qPCR) was used to quantify env gene mRNA in biopsies positive for MMTV-LV. Expression of the env gene was compared against different histopathological types of mammary tumor, LNM status, and metastasis by performing Ordinary One Way ANOVA followed by Tukey’s multiple comparisons test. MMTV-LV prevalence was found to have no significant association with LNM or metastatic history. As compared to normal control, expression of the env gene was significantly higher (>2.8 folds) in invasive samples (P-value: < 0.01). Expression was also higher (3.28 and 2.89 folds) in patient samples with LNM (P-value: 0.0006) or metastatic history (P-value: < 0.0001), respectively. We conclude that MMTV-LV prevalence is not associated with LNM status or breast cancer metastasis; samples with invasive phenotypes, nodal involvement, and metastasis exhibit significantly higher expression of the MMTV-like env gene.

نوع عمل المنشور
Research
اسم الناشر
Journal of Infection and Public Health
رقم المجلد
16
رقم الانشاء
9
الصفحات
1396-1402
مزيد من المنشورات
publications

The human respiratory syncytial virus (HRSV), recently known as the human orthopneumovirus (HOPV), continues to generate new variants with the ability to cause recurrent infections. Data…

بواسطة Reem M. Aljowaie, Mohamed A. Farrag, Tarad Abalkhail, Ibrahim M. Aziz, Abdulaziz M. Almuqrin, Noorah A. Alkubaisi, Asma N. Alsaleh & Fahad N. Almajhdi
2025
تم النشر فى:
Virus Genes
publications

Background

بواسطة Ali N. Alhafufi, Samy Kasem, Fahad N. Almajhdi, Hassan A. Albaqshi, Fanan A. Alaql, Ehab A. Rihan, Ehab M. Abd-Allah, Ameen A. Alyousaf, Yahya K. Aljasem, Najwa D. Aljehani, Mohei A. Haridy, Ahmed R. Alhimaidi & Ahmed S. Abdel-Moneim
2025
تم النشر فى:
Virology Journal
publications

Substantial research is currently conducted focusing on the development of promising antiviral drugs employing in silico screening and drug repurposing strategies against SARS-CoV-2.

بواسطة Ashis Kumar Goswami , Mourad A. M. Aboul-Soud ORCID logo EMAIL logo , Neelutpal Gogoi , Mohamed El-Shazly , John P. Giesy , Burak Tüzün , Ibrahim M. Aziz , Fahad N. Almajhdi and Hemanta Kumar Sharma
2024