Neuroprotective Activity of Garcinia pedunculata Roxb. ex Buch.-Ham. Fruit Extract Against Aluminium Chloride Induced Neurotoxicity in Mice.

Journal Article

2016

Aluminium chloride (AlCl3) is a known potent environmental neurotoxin causing
progressive neurodegenerative changes in brain. The present study was aimed to evaluate
the neuroprotective activity of aqueous extract of fruit rind of Garcinia pedunculata
on chronic exposure of aluminium chloride induced neurotoxicity in Swiss albino mice.
Albino mice were categorized into four different groups; Group 1–served as vehicle
control, Group 2 mice were administered with AlCl3 40 mg/kg body weight i.p. for 45
consecutive days. Groups 3 & 4 mice were administered with AlCl3 40 mg/kg body
weight i.p. for 45 consecutive days along with aqueous extract of fruits of G. pedunculata
200 & 400 mg/kg body weight. Chronic administration of AlCl3 developed behavioral
deficits, triggered lipid peroxidation and AChE activity and reduced levels of catalase,
glutathione peroxidase and histological aberrations. Co administration of aqueous extract
of G. pedunculata has attenuated the AlCl3 induced alteration in the behavioral, lipid
peroxidation, catalase, glutathione peroxidase, AChE and histological changes of brain
tissue. Thus the results of the present study have demonstrated the protective role of
aqueous extract of fruit rind of G. pedunculata against AlCl3 induced neurotoxicity.

• Volume Number: 50
• Issue Number: 3
• Magazine \ Newspaper: Indian Journal of Pharmaceutical Education and Research
• Pages: 435-441