Fabrication of Sustained Release System of Electrospun Poly (acrylic acid)/Dextran Nanofibers Using Emulsion Electrospinning as Wound Dressing Applications
The burst release of drug is a problem associated with the use of common blending electrospinning. This problem can be avoided via fabrication of core–shell nanofibers where drug can be coated with polymer nanofibers as a shell. Moreover, there is a need to provide wound dressing with prolonged system of sustained release to accelerate the recovery of the wound. Currently, electrospun ciprofloxacin loaded poly(acrylic acid)/Dextran (Cipro@PAA/Dex) core–shell nanofibers can be prepared in green method using emulsion electrospinning. For comparison study, blend electrospun nanofibers (Cipro/PAA/Dex) was also prepared. The entrapment of drug into the polymeric material and the interaction between polymer blends were confirmed by FT-IR. Moreover, DSC was used to identify the type of interaction between polymeric chains. Field emission scanning electron microscope (FE-SEM) was used to study the nanofiber morphology and transmission electron microscope (TEM) and confocal laser scanning microscope (CLSM) were used to confirm the formation of core–shell structure. In vitro drug release profile was monitored by UV-Vis spectrophotometer and the results showed that Cipro@PAA/Dex exhibited controlled release behavior whereas Cipro/PAA/Dex showed burst release behavior. Moreover, the release mechanism is kinetically followed diffusion
Fungal biofilms have caused several medical problems, resulting in significant morbidity and mortality as well as poor response to antifungal drugs.
Cellulose has been one of the most widespread materials due to its renewability, excellent mechanical properties, biodegradability, high absorption ability, biocompatibility and cheapness.
The burst release of drug is a problem associated with the use of common blending electrospinning. This problem can be avoided via fabrication of core–shell nanofibers where drug can be coated…