Anticarcinogenic Activity of Diallyl Disulfide

Journal Article
Al-Suhaibani, Entissar S. . 2015
Publication Work Type
ورقة بحثية
Magazine \ Newspaper
PARIPEX-Indian Journal of Research
Issue Number
Volume Number
Conference Date
Publication Abstract

Garlic (allium sativum) possesses anti-proliferative properties that can be used in anticancer intervention as promising
cancer chemo-preventive constituent. Diallyl disulfide (DADS) is an oil soluble sulfur organic compound. We investigated
DADS inhibitory activity against colon cancer (Caco-2) cells viability or proliferation. Cells were incubated with DADS at
concentrations, 400μM, 500μM, 600μM and 700μM for 72h at 37°C and 5% CO2. DADS effect was dose-dependently.
IC50 concentration of DADS, inhibited the viability and proliferation of treated Caco-2 cells in vitro and induced apoptosis
even by DNA fragmentation or Bcl-2 reaction expression inhibition. Future study will may deal with further investigations
of DADS possible usages as a new alternative or complementary chemotherapeutic agent for human cancer types specially colon cancer type.