Skip to main content
User Image

انتصار سليمان السحيباني


عضو هيئة تدريس

مركز الدراسات العلمية والطبية
كلية العلوم مبنى 5. الدور الثالث. مكتب 95
Journal Article

Anticarcinogenic Activity of Diallyl Disulfide

Al-Suhaibani, Entissar S. . 2015

Garlic (allium sativum) possesses anti-proliferative properties that can be used in anticancer intervention as promising
cancer chemo-preventive constituent. Diallyl disulfide (DADS) is an oil soluble sulfur organic compound. We investigated
DADS inhibitory activity against colon cancer (Caco-2) cells viability or proliferation. Cells were incubated with DADS at
concentrations, 400μM, 500μM, 600μM and 700μM for 72h at 37°C and 5% CO2. DADS effect was dose-dependently.
IC50 concentration of DADS, inhibited the viability and proliferation of treated Caco-2 cells in vitro and induced apoptosis
even by DNA fragmentation or Bcl-2 reaction expression inhibition. Future study will may deal with further investigations
of DADS possible usages as a new alternative or complementary chemotherapeutic agent for human cancer types specially colon cancer type.

Publication Work Type
ورقة بحثية
Volume Number
Issue Number
Magazine \ Newspaper
PARIPEX-Indian Journal of Research
more of publication

Aphids are important agricultural pests worldwide. Their control is largely based on chemical insecticides. One species that shows important invasive abilities and hostplant- related differences…

by Entissar AlSuhaibani, Costas Ch. Voudouris, Raed Al-Atiyat, Aise Kotzamumin, John Vontas, John T. Margaritopoulos

Previously, a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in human osteosarcoma
cell line. The study objective was to investigate if antiproliferative…

by Entissar S. Al-Suhaibani, Nermin El-Morshedi

Capsaicin (8-methyl-N-vanillyl-6-nonenamide), possesses anti-proliferative properties that can be used as anticancer

by Entissar S. Al-Suhaibani, Nermin El-Morshedi