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Dr. ABDULAZIZ MOHAMMED ALAMRI

Assistant Professor

BSc in Biochemistry, MSc and Ph.D. in Immunology, Biochemistry Department. College of Science, King Saud University

كلية العلوم
Office Address: Building 5 / Office : 2 A 60
publication
Journal Article
2023
Published in:

Diabetes-induced stimulation of the renin-angiotensin system in the rat brain cortex

Cerebrovascular disease is a threat to people with diabetes and hypertension. Diabetes can damage the brain by stimulating the renin-angiotensin system (RAS), leading to neurological deficits and brain strokes. Diabetes-induced components of the RAS, including angiotensin-converting enzyme (ACE), angiotensin-II (Ang-II), and angiotensin type 1 receptor (AT1R), have been linked to various neurological disorders in the brain. In this study, we investigated how diabetes and high blood pressure affected the regulation of these major RAS components in the frontal cortex of the rat brain. We dissected, homogenized, and processed the brain cortex tissues of control, streptozotocin-induced diabetic, spontaneously hypertensive (SHR), and streptozotocin-induced SHR rats for biochemical and Western blot analyses. We found that systolic blood pressure was elevated in SHR rats, but there was no significant difference between SHR and diabetic-SHR rats. In contrast to SHR rats, the heartbeat of diabetic SHR rats was low. Western blot analysis showed that the frontal cortexes of the brain expressed angiotensinogen, AT1R, and MAS receptor. There were no significant differences in angiotensinogen levels across the rat groups. However, the AT1R level was increased in diabetic and hypertensive rats compared to controls, whereas the MAS receptor was downregulated (p < 0.05). These findings suggest that RAS overactivation caused by diabetes may have negative consequences for the brain’s cortex, leading to neurodegeneration and cognitive impairment.

Publication Work Type
research article
Publisher Name
Saudi Journal of Biological Sciences
Publishing City
Riyadh, KSA
more of publication
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A major commercial fruit in Pakistan, citrus plays an important role in the economy of the country.

by Toqeer Abbas, Iftikhar Ahmad, Rab Nawaz, Muhammad Nazim, Mansoor K. Gatasheh, Abdulaziz Mohammad Alamri, Ahmed Muneeb
2023
publications

The mechanism by which anionic surfactants promote …

by Ajamaluddin Malik, Abdulaziz M. Al-Amri, Abdullah Alhomida, Javed Masood Khan
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Protein aggregation is implicated in different human diseases. It also makes the protein less desirable candidate for industry as they exhibit reduced biological activity. Proteins tend to…

by Javed Masood Khan*, Ajamaluddin Malik, Abdulaziz M. Al-Amri
2023