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Dr. ABDULAZIZ MOHAMMED ALAMRI

Assistant Professor

BSc in Biochemistry, MSc and Ph.D. in Immunology, Biochemistry Department. College of Science, King Saud University

كلية العلوم
Office Address: Building 5 / Office : 2 A 60
publication
Journal Article
2023
Published in:

Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

Abstract
The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg−1) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg−1 day−1 saline, and all other groups were administered SCOP (1 mg kg−1 day−1, i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain.

Publication Work Type
research article
Publisher Name
Royal Society
Magazine \ Newspaper
Royal Society Open Science
more of publication
publications

A major commercial fruit in Pakistan, citrus plays an important role in the economy of the country.

by Toqeer Abbas, Iftikhar Ahmad, Rab Nawaz, Muhammad Nazim, Mansoor K. Gatasheh, Abdulaziz Mohammad Alamri, Ahmed Muneeb
2023
publications

The mechanism by which anionic surfactants promote …

by Ajamaluddin Malik, Abdulaziz M. Al-Amri, Abdullah Alhomida, Javed Masood Khan
2023
publications

Protein aggregation is implicated in different human diseases. It also makes the protein less desirable candidate for industry as they exhibit reduced biological activity. Proteins tend to…

by Javed Masood Khan*, Ajamaluddin Malik, Abdulaziz M. Al-Amri
2023