Theoretical anti-tuberculosis activity and molecular docking investigation of N-silylated heterocyclic compounds with benzyl chloride catalyzed by ammonium sulfate-doped red algae (AS@CRA)
In this charge we designated a Hilbert-Johnson process by coupling of heterocyclic N-silylated with benzyl chloride at 100°C using the calcined red algae (CRA) doped with ammonium sulfate (AS), AS@CRA as a heterogeneous catalyst. The resulting examination systems, which included atomic absorption, BET methodology and X-ray diffraction (XRD), scanning electron microscopy (SEM/EDX), and Fourier transform infrared spectroscopy (FT-IR), were employed to describe these catalysts. The effect of catalyst and alkylated agent were extensively studied. This catalyst can also be recycled several times in this condensation, and lastly, we suggested a probable answer mechanism for this process. Moreover, our molecular docking investigation revealed the anti-tuberculosis potential of the synthesized compounds. Notably, the drug isoniazid exhibited higher binding energies compared to the products 2a, 2b, and 2c. Additionally, the ADME study suggests that highly efficacious synthetic compounds may possess anti-tuberculosis properties.
AD is a neurodegenerative disorder and is associated with the presence of amyloid-β plaques and neurofibrillary tangles leading to net loss of neurons, which demonstrates an urgent unmet need to…
The present study reports on the construction of orthorhombic crystalline α-MoO3 and the surface burial of Ag0 on it to enhance the catalytic degradation of metronidazole (MTZ).
This research work describes the synthesis and characterization of nickel phosphate (NiPO) nanostructures, which were successfully synthesized by the simple oil bath technique.