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Ayman A. Abdo MD, FRCPC, FACP

Professor

Vice Dean for Postgraduate Studies and Research, Executive Director of Academic Affairs

كلية الطب
Vice Dean for Postgraduate Studies and Research and Executive Director of Academic Affairs Office, 2nd Floor, College of Medicine Building, King Saud University, P.O. Box 7805, Riyadh 11472
publication
Journal Article
2015

The role of fibroscan in predicting the presence of varices in patients with cirrhosis.

, Al-Hamoudi WK, Abdelrahman AA, Helmy A, Anil S, Khamis N, Arafah M, Alswat KA, Suwefy YM, Sanai FM, Al Faleh F, Abdo AA. . 2015

BACKGROUND/AIM: Transient elastography is a relatively new, noninvasive method of measuring liver stiffness. This study aimed to evaluate the diagnostic accuracy of transient elastography and other noninvasive methods for the diagnosis of esophageal varices (EV) in patients with cirrhosis. METHODS: This cross-sectional study graded EV according to size in 145 consecutive patients with cirrhosis who underwent endoscopy, Fibroscan, and other noninvasive diagnostic methods. The accuracy of these diagnostic methods in diagnosing EV was evaluated on the basis of area under receiver operating characteristic (AUROC) curves. RESULTS: Elastography was successful in 123 patients. Of these, 54.5% had hepatitis C and 10.6% had hepatitis B. EV were absent in 39.8%, small EV was present in 24.4%, and large EV was present in 35.8% of patients. Fibroscan, aspartate aminotransferase-to-platelet ratio index, and international normalized ratio showed low accuracy in diagnosing EV in non-viral-related cirrhosis patients (AUROCs 0.66, 0.68, and 0.67, respectively). Fibroscan and aspartate aminotransferase-to-platelet ratio index were more accurate in measuring EV with a viral etiology (AUROCs 0.704 and 0.703, respectively). A cutoff value of 16.9 kPa was 83.8% sensitive in diagnosing EV in non-viral-cirrhotic patients, whereas a cutoff value of 19.9 kPa was 83.4% sensitive in diagnosing EV in patients with viral hepatitis. Fibroscan was moderately accurate in diagnosing grade I-EV and less accurate in diagnosing grades II and III EV in all cirrhotic patients, irrespective of the underlying etiology. CONCLUSION: Fibroscan might be useful in predicting the presence of EV in patients with cirrhosis with a viral etiology. However, endoscopy remains the gold standard for EV screening.

Magazine \ Newspaper
Eur J Gastroenterol Hepatol. 2015
Pages
Epub ahead of print
more of publication
publications

BACKGROUND/AIM: Transient elastography is a relatively new, noninvasive method of measuring liver stiffness. This study aimed to evaluate the diagnostic accuracy of transient elastography and…

by Al-Hamoudi WK, Abdelrahman AA, Helmy A, Anil S, Khamis N, Arafah M, Alswat KA, Suwefy YM, Sanai FM, Al Faleh F, Abdo AA.
2015