Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one‑pot cascade protocol
Chemistry Central Journal
Background: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated for their anticancer activity against FaDu hypopharyngeal tumor cells.
Findings: Interestingly, most compounds displayed cytotoxicities similar to the standard anticancer agent bleomycin, with two of them (5a and 5g) being slightly more active than the reference drug.
Conclusion: Synthesized compounds have also been evaluated for their apoptosis-inducing properties in a cancer cell model, finding that treatment with compounds 5a–e led to apoptotic cell death.
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A method of preparing biologically active derivatives from Calotropis gigantea flowers includes obtaining fresh Calotropis gigantea flowers, drying the fresh flowers, soaking the dried flowers in…
Background: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar…