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Javed Masood Khan

Assistant Professor

Researcher

كلية علوم الأغذية والزراعة
Department of Food Sciences, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia
المنشورات
مقال فى مجلة
2010

Interaction of bovine serum albumin with cationic single chain+ nonionic and cationic gemini+ nonionic binary surfactant mixtures

Rather, Mohammad Amin Mir, Nuzhat Gull, Javeed Masood Khan, Rizwan Hasan Khan, Aijaz Ahmad Dar, Ghulam Mohammad . 2010

The interaction of bovine serum albumin (BSA) with cetyltrimethylammonium bromide (CTAB), C16C4C16Br2, Brij58, and their binary mixtures has been studied using tensiometry, spectrofluorometry, and circular dichroism at physiological pH and 25 °C. The tensiometric profiles of CTAB and C16C4C16Br2 in the presence of BSA exhibit a single break at a lower surfactant concentration termed as C1 (concentration corresponding to saturation of the interface) compared to their critical micelle concentration (CMC) in the buffered solution. However, for Brij58, CTAB+Brij58, and C16C4C16Br2+Brij58, two breaks were observed, first at the critical aggregation concentraion (CAC), corresponding to onset of interaction with BSA and the second at C1 corresponding to saturation of the interface. The interaction of CTAB+Brij58 and C16C4C16Br2+Brij58 mixtures with the BSA solution is discussed in terms of competition between surfactant−surfactant and surfactant−BSA interactions. CTAB+Brij58 and C16C4C16Br2+Brij58 mixtures show nonideality with respect to mixed micelle formation, which is reflected in their interaction with the BSA. The interaction of CTAB+Brij58 with BSA decreases with increase in the mole fraction of CTAB in the mixture, whereas in C16C4C16Br2+Brij58 the reverse is the case. The results of the present study may prove fruitful in optimizing the properties of surfactant−protein mixtures relevant for many formulations.

رقم المجلد
114
رقم الانشاء
9
الصفحات
3197-3204
مزيد من المنشورات
publications

Serum albumins are chief carrier of ligands in blood, hence important in clinical biotechnology.

بواسطة Priyankar Sen, Sadaf Fatima, Javed Masood Khan, Rizwan Hasan Khan
2009
publications

The interaction of bovine serum albumin (BSA) with cetyltrimethylammonium bromide (CTAB), C16C4C16Br2, Brij58, and their binary mixtures has been studied using tensiometry, spectrofluorometry, and…

بواسطة Mohammad Amin Mir, Nuzhat Gull, Javeed Masood Khan, Rizwan Hasan Khan, Aijaz Ahmad Dar, Ghulam Mohammad Rather
2010
publications

This is the first report of its kind that well demonstrates that a lectin from Phytolacca americana[Pa-2 (P.

بواسطة Ejaz Ahmad, Shah Kamranur Rahman, Javed Masood Khan, Ankita Varshney, Rizwan Hasan Khan
2010