2-aminothiazoles derivatives and method of preparation thereof using super-paramagnetic iron oxide nanoparticles (spions)
A method of making a pyrazole compound includes mixing a diazonium salt with a reactant in the presence of a solvent, thereby coupling a diazo group of the diazonium salt to an α-carbon atom of the reactant to form a reaction intermediate having a formula of (I) or (II); mixing the reaction intermediate and hydrazine in the presence of a superparamagnetic iron oxide nanoparticles catalyst thereby cyclizing the hydrazine with an ester group of the reaction intermediate to form the pyrazole compound having a formula of (III) or (IV).
يقدم كتاب "استكشاف وتطوير المركبات الدوائية" نظرة شاملة على المراحل المتعددة والمعقدة لاستكشاف الأدوية وتطويرها، بدءًا من تحديد الأهداف الدوائية واكتشاف المركبات القائدة وصولاً إلى تطويرها صناعياً…
Heterocyclic chemistry is a broad branch of organic chemistry that contributes to almost one-third of all recent publications in the field, and it is becoming a more important subject for research…
A method of making a pyrazole compound includes mixing a diazonium salt with a reactant in the presence of a solvent, thereby coupling a diazo group of the diazonium salt to an α-carbon atom of…