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Dr Ali Daoud

Professor

Faculty

كلية العلوم
Department of Zoology College of Science King Saud University, Riyadh, Saudi Arabia
المنشورات
مقال فى مجلة
2017

Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice

Alkahtani, Saud Alarifi, Daoud Ali, Mohammed A Al Gurabi & Saad . 2017

Silver nanoparticles (AgNPs) possess properties that are important for industrial and medical applications. This study is aimed to investigate intra-peritoneal toxicity of AgNPs at 26, 52 or 78 mg/kg/ day for 5 days in mice Swiss albino mice. The effects on oxidative stress markers activities of serum superoxide dismutase (SOD) and catalase (CAT), levels of serum glutathione (GSH), apoptosis (TUNEL assay), DNA strand breaks (comet assay) in lymphocytes, as well as histopathological of kidney tissue were determined. AgNPs significantly increased SOD and CAT activities reduced GSH levels. In kidney apoptosis (TUNEL assay) while DNA strand breaks (comet assay) in lymphocytes revealed that AgNPs at concentration 78 mg/kg produced significant apoptosis and DNA damage. AgNPs also produced associated histological renal tissue damage. Evidence suggests that AgNPs-mediated alterations may be attributed to oxidative stress.

رقم المجلد
VOL. 99,
رقم الانشاء
NO. 2,
مجلة/صحيفة
Toxicological & Environmental Chemistry
الصفحات
294-301
مزيد من المنشورات
publications

Metal nanomaterials such as bismuth oxide nanoparticles (Bi2O3NPs) have been extensively used in cosmetics, dental materials,pulp capping, and biomedical imaging. There is little knowledge about…

بواسطة Ali Alamer1 & Daoud Ali2 & Saud Alarifi2 & Abdullah Alkahtane2 & Mohammed AL-Zharani3 & Mohamed M. Abdel-Daim2,4 & Gadah Albasher2 & Rafa Almeer2 & Nouf K. Al-Sultan2 & Abdulaziz Almalik1,5 & Ali H Alhasan1,5 & Saa
2021
publications

Silver nanoparticles (AgNPs) possess properties that are important for industrial and medical applications. This study is aimed to investigate intra-peritoneal toxicity of AgNPs at 26, 52 or 78 mg…

بواسطة Saud Alarifi, Daoud Ali, Mohammed A Al Gurabi & Saad Alkahtani
2017
publications

The present work was designed to investigate the effect of palladium nanoparticles (PdNPs) on human skin malignant melanoma (A375) cells, for example, induction of apoptosis, cytotoxicity, and DNA…

بواسطة Saud Alarifi, Daoud Ali, Saad Alkahtani, and Rafa S. Almeer
2017