Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
, Nasser M. Al-Daghri, Chiara Pontremoli, Rachele Cagliani, Diego Forni, Majed S. Alokail, Omar S. Al-Attas, Shaun Sabico, Stefania Riva, Mario Clerici & Manuela Sironi . 2017
The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels.
Publication Work Type
PHD
Magazine \ Newspaper
BMC Evolutionary Biology
more of publication
Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…
2023