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Nasiruddin Khan

Assistant Professor

Assistant Professor

كلية العلوم
Dr. Nasiruddin Khan, Room 2A51, Building 5, Biomarkers Research Program, College of Science, King Abdullah road, Riyadh, 11451,
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Short _Biography_CV

Bio
I have completed my Ph.D (October 2010) from Faculty of Pharmacy, Department of Nutrition and Food Science, University of Barcelona, Spain under the guidance of Assistant Prof. Cristina Andres Lacueva. My thesis topic is “Cocoa and their effect on Inflammatory Biomarkers of Atherosclerosis”.
During my doctoral thesis I had the opportunity to work extensively in the field of food science and nutrion specially food products like cocoa, their metabolites, and chocolate to clearly understand various complications involved in cardiovascular diseases, like Inflammation in Atherosclerosis in human subjects. I studied different biomarkers of inflammation to relate their effect on initial phase of inflammation in atherosclerosis. The role of monocytes and lymphocytes in this process is also a major part of my thesis.
I am also well aware of bioavailability factor that plays significant role in human diet and nutrition.
I also worked with the topic of ER stress in HepG2 cells and Caco-2 cells to look their effect as antioxidants and their further role at genetic level.
Under “Foreign Student Distance Course” programme , I learnt techniques like Transmigration Assay at University of Ulm, Stuttgart, Germany and during my stay in King’s College, London I worked with Human cell lines like Human Aortic Smooth Muscle Cells (HASMC’s) and Bovine Aortic Endothelial Cell (BAEC) to study the effect of cocoa metabolite on Reactive Oxygen Species (ROS) production and gene expression of Heme Oxygenase-1(HO-1) and Nuclear factor erythroid 2-related factor 2 (Nrf2) in-vitro.
In addition to my Masters in Nutrition and Food Science I have got good understanding of Chemistry and Biotechnological aspects.
CV Text

  
 
Curriculum Vitae
               
 
PERSONAL INFORMATION
 
Name                                         Nasiruddin Khan
Date of Birth                             1st July 1978
 
Marital Status                            Married

Languages Known                    English, Spanish, Hindi, Urdu
Nationality                                Indian
 
Address                                      Dr. Nasiruddin Khan (Ph.D)
                                                   Assistant Professor
                                                   Room 2A51, Building 5
                                                   Biomarkers Research Program, College of Science, 
                                                   King Saud University PO Box 2455 
                                                   King Abdullah road, Riyadh, 11451
                                                   Kingdom of Saudi Arabia
 
 
Electronic mail:                        knasiruddin@ksu.edu.sa,
                                                  nasiruddin2006@gmail.com
 
Mobile phone No:                    (+966) 540224502                                                
                                                
                                                 
 
 
EDUCATION
                                                                                               
                                                                                                                                                
 
2006- 2010    Ph.D. from Faculty of Pharmacy, Department of Nutrition and Food Science, University of Barcelona, Spain.
 
2007- 2008    Master in Nutrition and Metabolism from University of Barcelona, Spain.
 
2000- 2002     Master in Science (Inorganic Chemistry), from Aligarh Muslim University,
                        Aligarh, India.
 
2002- 2004     Master in Science (Biotechnology), from Bundelkhand University, Jhansi,
                        India.
 
1998- 2000     B.Sc. Chemistry (Hons.) from Aligarh Muslim University, Aligarh, India.
Responsibilities: Assistant Professor
 (December 2011-December 2013)
 
 

  • Mainly involved in research activities including nutrition and dietary intake, vitamin D, osteoporosis, metabolic syndrome and diabetes.
  • Experimental and theoretical training to Bachelor’s and Master’s    students during summer projects.
  • Guidance to Ph.D students.
  • Holding responsibility for the following NPST projects,

 
 

  1. Project Title: Premature biological aging in Saudi adults with Type 2 diabetes and the influence of endotoxinemia.

PI: Dr. Nasiruddin Khan, Institution: King Saud University, Technology Sector: Medicine and Health, Project Code: 12-MED2565-02.
2. Project Title: A study of dietary intervention for moderating fat intake in Saudi subjects with metabolic diseases.PI: Dr. Nasiruddin Khan, Institution: King Saud University, Technology Sector: Medical And Health, Project Code: Project # 11-MED1907-02.

  1.  
    Professional Experience:
     
    (August 2009- December 2009)
    Distance training to study “The effect of cocoa metabolites on production of reactive oxygen species ( ROS) and gene expression (HO-1, Nrf2) in vitro” with animals and human cell lines like HASC’s and BAEC, performed at Cardiovascular Division, King’s College London.
     
    (October 2007- November 2007)
                                   Distance training to learn Transmigration Technique (Monocytes and Lymphocytes) at University of Ulm, Stuttgart, Germany.
     
    (January 2004 – July 2004) 
                                 Worked on synthesis and screening of antimicrobial  peptides at Institute                            of Genomics and Integrative Biology (IGIB), New Delhi, India.
     
    (July 2003 – September 2003)                
                          Worked for a project entitled “Antimicrobial Activity of clove oil and its                possible role in the treatment of urogenital infection” from the Department of Biotechnology, Aligarh Muslim University, Aligarh, India.
     
    Publications:
     
     
  2.  

1. Cocoa polyphenols and inflammatory markers of cardiovascular disease.

Khan N, Khymenets O, Urpí-Sardà M, Tulipani S, Garcia-Aloy M, Monagas M, Mora-Cubillos X, Llorach R, Andres-Lacueva C. Nutrients. 2014 Feb 21;6(2):844-80.
 
2. Association of dietary fatty acids intake with pro-coagulation and inflammation in Saudi Adults.Omar S Al-Attas, Nasser M Al-Daghri, Majed S Alokail,  Khalid M Alkharfy, Nasiruddin Khan, Hanan A Alfawaz,  Ibrahim A Aiswaidan, Abdulrahman S Al-Ajlan, George P Chrousos. Asia Pac J Clin Nutr. 2014;23(1):55-64.
 
3. Selected Dietary Nutrients and the Prevalence of Metabolic Syndrome in Adult Males and Females in Saudi Arabia: A Pilot Study.Nasser M. Al-Daghri, Nasiruddin Khan, Khalid M. Alkharfy, Omar S. Al-Attas, Majed S. Alokail, Hanan A. Alfawaz , Abdulaziz Alothman and Paul M. Vanhoutte.
Nutrients 2013, 5, 4587-4604.
 
4. Assessment of selected nutrients intake and adipocytokines profile among Saudi children and adults.Al-Daghri NMAl-Othman AAlkharfy KMAlokail MSKhan NAlfawaz HAAiswaidan IAChrousos GP. Endocr J. 2012 59(12):1057-63
 
5. Regular consumption of cocoa powder with milk increases HDL cholesterol andreduces oxidized LDL levels in subjects at high-risk of cardiovascular disease.
Nasiruddin Khan; Maria Monagas; Cristina Andres-lacueva; Rosa Casas; Mireia Urpi-Sarda; Rosa Lamuela-Raventos; Ramon Estruch. Nutrition, Metabolism & Cardiovascular Disease (2011) xx, 1-8.
 
6. Solution equilibria of the i-motif-forming region upstream of the B-cell lymphoma-2 P1 promoter.Khan N, Aviñó A, Tauler R, González C, Eritja R, Gargallo R. Biochimie. 2007 Dec;89(12):1562-72.

7. Effects of cocoa powder in patients at high risk of cardiovascular disease. Targeted and metabolomic study of biomarkers of consumption, effect and inflammation.Nasiruddin Khan; Maria Monagas, Rafael Llorach, Mireia Urpi-Sarda, Montse Rabassa, Ramon Estruch, Cristina Andres-lacueva. AgroFood industry hi-tech - May/June 2010 - vol 21, n 3.
 
8. Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.Monagas M, Khan N, Andres-Lacueva C, Casas R, Urpí-Sardà M, Llorach R, Lamuela-Raventós RM, Estruch R. Am J Clin Nutr. 2009; 90(5):1144-50.
 
9. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells.Monagas M, Khan N, Andrés-Lacueva C, Urpí-Sardá M, Vázquez-Agell M, Lamuela-Raventós RM, Estruch R. Br J Nutr. 2009;102(2):201-6
 
10. Distribution of epicatechin metabolites in lymphoid tissues and testes of young rats with a cocoa-enriched diet.Urpi-Sarda M, Ramiro-Puig E, Khan N, Ramos-Romero S, Llorach R, Castell M, Gonzalez-Manzano S, Santos-Buelga C, Andres-Lacueva C. Br J Nutr. 2010;26:1-5.    

11. Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry.Urpi-Sarda M, Monagas M, Khan N, Llorach R, Lamuela-Raventós RM, Jáuregui O, Estruch R, Izquierdo-Pulido M, Andrés-Lacueva C. J Chromatogr A. 2009, 23; 1216(43):7258-67.
 
12. Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats.Urpi-Sarda M, Monagas M, Khan N, Lamuela-Raventos RM, Santos-Buelga C, Sacanella E, Castell M, Permanyer J, Andres-Lacueva C. Anal Bioanal Chem. 2009; 394(6):1545-56
 
13. Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process.Andres-Lacueva C, Monagas M, Khan N, Izquierdo-Pulido M, Urpi-Sarda M, Permanyer J, Lamuela-Raventós RM. J Agric Food Chem. 2008;14;56(9):3111-7
 
BOOK CHAPTER
1 - Nasiruddin Khan, Rafael Llorach, Mireia Urpi-Sarda, Raul Zamora-Ros, Antonio Cherubini, Cristina Andres-Lacueva, Approaching Dietary Components and Immune Function (Nutrition and Health, 2010, Part 5, 397-420, DOI: 10.1007/978-1-60761-061-8_23): Resveratrol and Bioactive Flavonoids in Immune function. 2010. Watson, Ronald R.; Zibadi, Sherma; Preedy, Victor R. (Eds.) ISBN: 978-1-60761-060-1. Springer Ed.
 
2 - Andres-Lacueva, C.; Medina-Remon, A.; Llorach, R.; Urpi-Sarda, M.; Khan, N.; Chiva, G.; Zamora-Ros, R.; Rotches-Ribalta, M.; Lamuela-Raventos, RM. Phenolic compounds, Chemistry and occurrence in fruits and vegetables. Fruit and vegetable phytochemicals: Chemistry, nutritional value and stability. Blackwell. 2009 (UNITED KINGDOM) ISBN: 978-0-8138-0320-3.
 
3- Nasiruddin Khan, Maria Monagas, Mireia Urpi-sarda, Rafael Llorach, Cristina Andres Lacueva. Contribution of bioactive foods and their emerging role in immunomodulation, inflammation and arthritis.
ELSEVIER (2011)
 
4- Nasiruddin Khan , Nathalie M. Nicod.  Biomarkers of cocoa consumption.
Springer Verlag Italia Srl (2011)
 
5- Mireia Urpi-Sarda, Rafael Llorach, Maria Monagas, Nasiruddin Khan, Maria Rotches-Ribalta, Elena Roura, Rosa Lamuela-Raventos, Ramón Estruch and Cristina Andres-Lacueva.
Effect of cocoa powder in the prevention of cardiovascular disease: Biological, consumption and inflammatory biomarkers. A metabolomic approach.
(e-Book) Transworld Research Network
Recent Advances in Pharmaceutical Sciences, 2011
 
International Conferences:
Oral presentation:
Vitamin D Status in Saudi School Children Based on Knowledge.
The 2nd Saudi Osteoporosis Society International Conference (March 12-13, 2014, Marriott Hotel, Riyadh, KSA)
 
Posters:
 

  1. Selected dietary nutrients and the prevalence of metabolic syndrome in adult males and females in Saudi Arabia.

IUNS 20th International Congress of Nutrition, 15-20th September 2013 – Granada, Spain.
 
 

  1. Effect of cocoa-enriched diet on the accumulation of epicatechin metabolites in lymphoid tissues and testes of young rats.

2009 , ICPH  4th International Conference on Polyphenols and Health, 7-11 December, 2009, Yorkshire, Harrogate (UK).
 

  1. Daily intake of cocoa with milk have marked effect on biomarkers of atherosclerosis.

2009, 15th Annual Scandinavian Atherosclerosis conference, 22- 25 April, 2009, Copenhagen, Denmark.
 

  1. Anti-inflammatory properties of phenolic acids derived from microbial metabolism.

2008, 24th international conference on polyphenols, 8-11 July, 2008, Salamanca, Spain.
 
Meetings, Seminar and Exhibition Attended:
1 – Poster:
Dihydroxylated phenolic acids derived from microbial metabolism of cocoa procyanidins reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells
2008, XΙΙ Food Studies Meeting on Health and Chemistry: Healthy Ingredients.
26-27th November, 2008, Barcelona, Spain.
 
2 - Seminar Expert Tour Agilent, about Productivity of GC, GC/MS and about New GC Triple Quadrupole Agilent 7000A.
21 January, 2009, Barcelona, Spain.
 
3 - International Food and Beverages Exhibition.
10-13 March, 2008, Barcelona, Spain.
 
4 - Seminar: New version of Data Analysis with SPSS Version 16.
21 February, 2008, Barcelona, Spain.
 
5 - Seminar: World Tour 2007 Agilent Technologies “modern techniques of MS for the analysis of phenolic metabolites in biological samples”.
18 April, 2007, Barcelona, Spain.
 
6 – Seminar: “Comocaixa” about factors influencing longevity, prospects of Metabolism, Evolutionary Biology  and Ontogeny.
18 October, 2007, Barcelona, Spain.
 
7 - Seminar Waters “Recent advances in the identification of metabolites and metabonomics”, about metabonomics and interpretation of datas.  New methods for determination of metabolites.
6 July, 2006, Barcelona, Spain.
 
References:
 
 

1- Francesco Visioli , Senior Investigator
FUNDACIÓN IMDEA ALIMENTACIÓN
C/ Faraday, 7 - 1ª planta D1.06
Parque Científico de Madrid
Campus Universitario de Cantoblanco
28049 Madrid
Telephone : (+34) 912796986
E-mail : francesco.visioli@imdea.org
 
2- Dr. Cristina Andres Lacueva (Ph.D), Associate Professor
Faculty of Pharmacy
Nutrition and food science department
University of Barcelona
Av. De Joan XX111,  s/n
08028 Barcelona, Spain
Telephone : (+34) 93 403 48 40
E-mail :  candres@ub.edu
 
3- Dr. Ramon Estruch, M.D, Ph.D
Department of Internal Medicine, Hospital Clinic
University of  Barcelona, Villarroel 170, 08036
Barcelona, Spain.
Tel/Fax (+34) 93 227 93 65
E-mail :  restruch@clinic.ub.es
4- Dr. Rosa Maria Lamuela Raventos   (Ph.D), Professor
Faculty of Pharmacy
Nutrition and food science department
University of Barcelona
Av. De Joan XX111,  s/n
08028 Barcelona, Spain
Telefon: +34 934034843
Fax: +34934035931
E-mail: lamuela@ub.edu