Method of synthesizing (E)-1,2-di(pyridin-2-yl) ethene-1,2-diol
Zarrouqk), Nabil Ahmed Qassim Al-Zeqri, Ismail Khalil Warad, Firas Fandi Awwadi, Ali Mohammed Alsalme, Anas Khaled Abed Alali, Abdelkader . 2018
The method of synthesizing (E)-1,2-di(pyridine-2-yl)ethene-1,2-diol involves dimerization of 2-pyridinecarboxaldehyde (also referred to herein as “picolinaldehyde”). The synthesis of the desired ethene-1,2-diol is achieved using a Cu(II) catalyst to dimerize picolinaldehyde under mild conditions. Preferably, the Cu(II) catalyst is a Cu(II)/neocuproine (2,9-dimethyl-1,10-phenanthroline) complex, or other Cu(II)/phen complex. The reaction in this embodiment may occur at room atmosphere and in ambient light conditions using a water/ROH solvent. The exemplary ethene-1,2-diol product, (E)-1,2-di(pyridin-2-yl)ethene-1,2-diol has the following structural formula:
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