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Dr. MIKHLID HAMMAD ALMUTAIRI د. مخلد بن حامد المطيري

Associate Professor

Faculty member in Molecular Genetics

كلية العلوم
College of Sciences No. 5, ground floor, Office No. AB 67
publication
Journal Article
2021

Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population

Semlali, Mikhlid H. Almutairi , Bader O. Almutairi , Turki M. Alrubie, Sultan N. Alharbi, Narasimha R. Parine, Abdulwahed F. Alrefaei, Ibrahim Aldeailej, Abdullah Alamri, Abdelhabib . 2021

The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint. Polymorphisms in these genes can lead to the development of various diseases. This study was conducted to examine a potential association between tobacco substance usage (TSU) and single-nucleotide polymorphism (SNP) at the exon regions of the P53, P21, and MDM2 genes by comparing populations of smokers and non-smokers from Saudi Arabia. P53 rs1042522 (C/G), P21 rs1801270 (A/C), and MDM2 rs769412 (A/G) were investigated by genotyping 568 blood specimens: 283 from male/female smokers and 285 from male/female non-smokers. The results obtained from the smokers and their control non-smokers were compared according to age, sex, duration of smoking, and type of TSU. Heterozygous CG, homozygous GG, and CG+GG genotypes, as well as the G allele of rs1042522 were significantly associated with TSU in Saudi smokers compared with non-smokers. The C allele frequency of rs1801270 was also associated with TSU in smokers (OR = 1.33, p = 0.049) in comparison with non-smokers, in younger smokers (�29 years) (OR = 1.556, p = 0.03280) in comparison with non-smokers of the same age, in smokers who had smoked cigarettes for seven years or less (OR = 1.596, p = 0.00882), and in smokers who had consumed shisha (OR = 1.608, p = 0.04104) in comparison with the controls. However, the genotypic and allelic frequencies for rs769412 did not show significant associations with TSU in Saudis. The selected SNP of P53 was strongly associated with TSU and may be linked to TSU-induced diseases in the Saudi Arabian population

Volume Number
16
Issue Number
1
Magazine \ Newspaper
PLOS ONE
Pages
1-25
more of publication
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Diarrhea is a serious health concern in livestock, affecting productivity and animal welfare. However, it remains a significant threat. Various practical therapies are being explored, such as…

by 1. Houkang Ding, Ming Li, Ning Ma, Shahid Ali Rajput, Mikhlid H. Almutairi, Bader O. Almutairi, Zhaoqing Han, Aituan Ma, Dengshan Shiau
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publications

Selenium nanoparticles (Se-NPs), a nanoscale form of selenium, and sodium selenite (SS), an inorganic selenium compound, were incorporated into poultry feed to assess their effects on…

by 3. Aimen Khalid, Sania Satti, Anqash Ayyub, Faisal Nawab, Muhammad Tahir, Shabana Naz, Mikhlid H. Almutairi, Abdulwahed Fahad Alrefaei, Rifat Ullah Khan, Demilade Israel Ibiwoye
2025
publications

Aqueous extracts of Leea crispa used for producing silver nanoparticles (AgNPs) with the supplementation of the external capping substance, were determined by UV-Visible spectroscopy. The…

by Tejshwini Doddamani, Balamuralikrishnan Balasubramanian, Siddappa Kakkalameli, Joseph Kadanthottu Sebastian, Manikantan Pappuswamy, Bader O. Almutairi, Mikhlid H. Almutairi, and Azharuddin Daphedar
2025