The main focus of my research is to conduct rigorous translational nanomedicine research for promising improvements of potential therapeutics. This mainly encompasses the development and evaluation of ocular drug delivery systems. Basically, nanoformulations and their physicochemical characterizations using solid lipids as well as polymeric and self-assembled systems are of major interest. I am currently utilizing poly (D, L-lactic-co-glycolic acid) (PLGA) to prepare and optimize nanoparticles to target dendritic cells for cancer vaccination and in another line development of ophthalmic nanoformulations. Moreover, novel systems such as solid lipid nanoparticles, in-situ sol gel system, miroemulsions, nanoemulsions and the surface-modified nanoparticulate drug delivery systems.
areas of expertise
Professor Mohd Abul Kalam is an internationally recognized expert in pharmaceutics, nanomedicine, and advanced drug delivery systems, with particular expertise in the design, development, optimization, and evaluation of nano-enabled formulations for ocular, transdermal, oral, and nose-to-brain drug delivery. His research focuses on polymeric nanoparticles, solid lipid nanoparticles, nanocrystals, polymeric micelles, liposomes, nanoemulsions, chitosan-based nanocarriers, and thermoresponsive in situ gels to enhance the solubility, bioavailability, and therapeutic efficacy of challenging drug molecules. A significant portion of his work has been dedicated to ocular drug delivery, including the development of nanoparticle-based and sustained-release systems for the treatment of ocular infections, inflammation, glaucoma, and other eye disorders. He also has extensive expertise in formulation characterization (particle’s characterization by DLS, solid-state characterizations by DSC, XRD, and ATR-FTIR), optimization using Quality by Design (QbD) approaches, preclinical evaluation of nanocarriers, pharmacokinetic studies, and analytical method development and validation using UV, HPLC, and UPLC techniques. With more than 115 peer-reviewed publications and recognition (7 consecutive years) among the world's top 2% scientists, Prof. Kalam has made substantial contributions to translating nanotechnology-based pharmaceutical systems into effective therapeutic platforms for improved patient care.
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Mohammad Raish, Mohd Abul Kalam, Ajaz Ahmad, Mudassar Shahid, Mushtaq Ahmad Ansari, Abdul Ahad, Raisuddin Ali, Yousef A. Bin Jardan, Aws Alshamsan, Musaed Alkholief, Khalid M. Alkharfy, Ibrahim Abdelsalam Abdelrahman.
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Essam A. Tawfik, Aws Alshamsan, Mohd Abul Kalam, Mohammad Raish, Musaed Alkholief, Paul Stapleton, Kirsten Harvey, Duncan Q.M. Craig, Susan A. Barker
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Mohammed Muqtader Ahmed, Farhat Fatima, Md. Khalid Anwer, Elmutasim Osman Ibnouf, Mohd Abul Kalam, Aws Alshamsan, Mohammed F. Aldawsari, Ahmed Alalaiwe, Mohammad Javed Ansari