PHRM 315 (Pathophysiology, Drug Action, and Therapeutics 2)

COURSE DESCRIPTION
This PDAT course is the second of ten integrated courses called Pathophysiology, Drug Action and Therapeutics courses’ modules. The course seeks to relate disease pathophysiology to
treatment with drugs integrating the principles of medicinal chemistry, pharmacology,
pharmacokinetics, and pharmacotherapeutics to the following areas:
- Endocrine disorders
- Respiratory diseases
COURSE OBJECTIVES
Introduce the students to the pharmacology and medicinal chemistry of the endocrine and respiratory system and integrate that with the pathophysiology and pharmacotherapeutics of various endocrine and respiratory diseases.
COURSE LEARNING OUTCOMES
- Identify for each drug or drug class discussed its mechanism and site(s) of action, pharmacological effects, pharmacokinetics, and therapeutic uses.
- Describe the function of the autonomic, cholinergic and adrenergic nervous system.
- Recognize the important adverse reactions and interactions with other drugs, and relative and/or absolute contraindications.
- Identify biochemical mechanism of action of a biologically active compound from its chemical structure.
- Identify and define presenting signs and symptoms of cardiovascular disease and dyslipidemia.
- Understand the pathophysiologic processes associated with a particular disease state and how it is affected by drug therapy.
- Demonstrate how defects and imbalances in the autonomic, cholinergic and adrenergic nervous system can result in various cardiovascular diseases.
- Relate the chemical structure of a biologically active compound to the receptor or active site binding using enzyme or receptor models.
- Predict the biological response, if any, from a chemical structure on the therapeutic targets covered in this course.
- Relate in vitro structural modifications, which alter in vivo biotransformation of drugs.
- Relate the structural features of a compound to the physiochemical properties, which may have a major effect on its biological response, or on the design of modern therapeutic agents.
- Relate the structural features of a compound to its physical properties, which may influence its formulation or administration.
- Design initial treatment regimen, or alteration in a regimen, for a patient based on information concerning the disease state, previous drug therapy, and laboratory data.
- Develop a therapeutic plan for monitoring treatment of a patient with a cardiovascular disease.
- Conduct a counseling session to the patient or care givers regarding the appropriate administration, adverse effects, and drug interactions associated with prescribed medications.
- Integrate pharmacokinetic and pharmacogenomic principles to determine appropriate anticoagulation dosing.