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Promy Virk

Associate Professor

Associate Professor

كلية العلوم
5T104
publication
Journal Article
2022

Attenuating effect of Indian mustard (Brassica juncea) seed and its nano formulation on arsenic induced-oxidative stress and associated genotoxicity in rat.

Abstract
Objective
Arsenic (As) has been in the forefront of toxicological research due to its continual worldwide human exposure and its adverse effects including genotoxicity. The study assessed the potential ameliorative effect of Indian mustard seeds (Brassica juncea) and their nanoparticles against arsenic toxicity.

Methods
Male Wistar rats were used for the exposure study. Group I was control and group V was exposed only to the nanoparticles. Groups II, III, and IV were exposed to 10 mg/kg sodium arsenite for two weeks. Groups III and IV were treated with mustard seeds and the nanoparticles (500 mg/kg) respectively.

Results
Arsenic intoxication caused a marked increase in the levels of As in the brain. Additionally, oxidative damage was exhibited with significantly enhanced levels of serum 8-OHdG and hepatic p53 and pS15. The pictographs and the analyzed parameters of the COMET assay illustrated DNA damage with significantly increased values of tail moment and length. Treatment with mustard seeds and its nanoparticles markedly reversed the adverse effects of As toxicity, which is attributed to the presence of a gamut of constituent phytocompounds in the mustard seeds.

Conclusion
Taken together the nano formulation was more efficacious and could be introduced as a potential nutraceutical to combat metal toxicity.

Publication Work Type
Master
Publisher Name
ELSEVIER
Publishing City
NETHERLANDS
Volume Number
34
Issue Number
6
Magazine \ Newspaper
Journal of King Saud University - Science,
Pages
102134
more of publication
publications

Abstract: As the human population continues to escalate, its requirement for clean water is also
increasing. This has resulted in an increased dependency on wastewater effluent to maintain…

by Manal A. Awad 1 , Promy Virk 2,* , Awatif A. Hendi 3 , Khalid Mustafa Ortashi 4 , Najla AlMasoud 5 and Taghrid S. Alomar 5,*
2023
Published in:
MDPI
publications

The aim of the present study was a qualitative assessment of potential microplastics (MPs) in the sewage effluent collected from a local sewage treatment plant located in Riyadh City, Saudi Arabia…

by Manal Qayyadh Alanazi 1, Promy Virk 2, Seham Soliman Alterary 3, Manal Awad 4, Zubair Ahmad 1, Abdulrehman M Albadri 5, KalidM Ortashi 6, Mohieldeen Mahgoub A Ahmed 7, Mohamed Ismail Ali Yousef 7, Mai Elobeid 1, Ebtesam Abdullah Al-Qahtani
2023
Published in:
Elsevier