Histological Effects of Different Polyunsaturated Fat Types in the Diet: Omega-3 and Omega-6.
EL-Kenawy.(, Maha Hasan Daghestani, Promy Virk and Ayman EL-Meghawry . 2012
Abstract: The beneficial effects of polyunsaturated fats and omega 3 supplements in human and animal
nutrition have been widely discussed and established though clinical and experimental studies. In this study
the High-Fat (HF) diet rodent models were used to evaluate the effects high doses of two polyunsaturated
fats omega-3 and omega-6 on metabolic parameters and histology of liver and kidney. Male and female
Wistar rats were fed High-Fat (HF) diets containing Omega-3 fish oil supplements (HF-F) and Omega-6 corn
oil (HF-C) at a level that was equivalent to three times the maximum safe daily dosage and the control group
was fed with regular laboratory chow. Body weight and plasma parameters of glucose, cholesterol and
triglycerides were measured after a 8 week diet course. Rats fed both the high fat oil based diets (HF-F, HFC) reported a significantly higher body weight gain than the control group. Plasma triglyceride levels were
significantly higher in the high fat diets being highest in the fish oil based diet. Both the high fat diets fed
animals (HF-F, HF-C) showed pronounced hepatic micro vesicular steaosis and renal interstitial
inflammation in comparison with the control in the histological studies. Thus this study demonstrated that
high fat diets with polyunsaturated fats including omega-3 rich fish oil could induce dyslipidemia and obesity
in rodent models reflecting signs of metabolic syndrome in the humans
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