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Promy Virk

Associate Professor

Associate Professor

كلية العلوم
5T104
publication
Journal Article
2012

Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model.

AlOlayan, Zeinab K. Hassan, Mai A. Elobeid, Promy Virk, Sawsan A. Omer, Maha ElAmin, Maha H. Daghestani, and Ebtisam M. . 2012

Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage. Bisphenol A (BPA) is a contaminant
with increasing exposure to it and exerts both toxic and estrogenic effects on mammalian cells. Due to limited information
concerning the effect of BPA on liver, this study investigates whether BPA causes hepatotoxicity by induction of oxidative stress in
liver. Rats were divided into five groups: The first four groups, BPA (0.1, 1, 10, 50 mg/kg/day) were administrated orally to rats for
four weeks. The fifth group was taken water with vehicle. The final body weights in the 0.1 mg group showed a significant decrease
compared to control group. Significant decreased levels of reduced glutathione, superoxide dismutase, glutathione peroxidase,
glutathione-S-transferase, glutathione reductase and catalase activity were found in the 50 mg BPA group compared to control
groups. High dose of BPA (50 mg/kg) significantly increased the biochemical levels of ALT, ALP and total bilirubin. BPA effect on
the activity of antioxidant genes was confirmed by real time PCR in which the expression levels of these genes in liver tissue were
significantly decrease compared to control. Data from this study demonstrate that BPA generate ROS and reduce the antioxidant
gene expression that causes hepatotoxicity.

Publication Work Type
Research
Volume Number
2012
Magazine \ Newspaper
Oxidative Medicine and Cellular Longevity
Pages
194829 to 194835
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